Search Results - "Zhang, Lu‐Yong"

Synthesis and Target Identification of Benzoxepane Derivatives as Potential Anti‐Neuroinflammatory Agents for Ischemic Stroke by Gao, Cheng‐Long, Hou, Gui‐Ge, Liu, Jin, Ru, Tong, Xu, Ya‐Zhou, Zhao, Shun‐Yi, Ye, Hui, Zhang, Lu‐Yong, Chen, Kai‐Xian, Guo, Yue‐Wei, Pang, Tao, Li, Xu‐Wen

“…Benzoxepane derivatives were designed and synthesized, and one hit compound emerged as being effective in vitro with low toxicity. In vivo, this hit compound…”
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Lnc RNA SNHG20 participated in proliferation, invasion, and migration of breast cancer cells via miR‐495 by Guan, Yan‐Xing, Zhang, Meng‐zhi, Chen, Xue‐Zhong, Zhang, Qing, Liu, Shao‐Zheng, Zhang, Yong‐Lu

“…To explore the mechanism of lnc SNHG20 in the regulation of proliferation, invasion, and migration of breast cancer cells. mRNA levels of SNHG20, miR‐495, and…”
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Deoxypodophyllotoxin: A promising therapeutic agent from herbal medicine by Khaled, Meyada, Jiang, Zhen-Zhou, Zhang, Lu-Yong

“…Recently, biologically active compounds isolated from plants used in herbal medicine have been the center of interest. Deoxypodophyllotoxin (DPT), structurally…”
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The hypoglycemic mechanism of catalpol involves increased AMPK-mediated mitochondrial biogenesis by Xu, Deng-qiu, Li, Chun-jie, Jiang, Zhen-zhou, Wang, Lu, Huang, Hong-fei, Li, Zhi-jian, Sun, Li-xin, Fan, Si-si, Zhang, Lu-yong, Wang, Tao

“…Mitochondria serve as sensors of energy regulation and glucose levels, which are impaired by diabetes progression. Catalpol is an iridoid glycoside that exerts…”
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Bakuchiol Contributes to the Hepatotoxicity of Psoralea corylifolia in Rats by Li, Zhi‐Jian, Abulizi, Abudumijiti, Zhao, Guo‐Lin, Wang, Tao, Zhou, Fan, Jiang, Zhen‐Zhou, Aibai, Silafu, Zhang, Lu‐Yong

“…Psoralea corylifolia L. (Fructus Psoraleae) is widely used in Asia, but there are concerns about hepatotoxicity caused by constituents such as psoralens and…”
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Nogo-66 inhibits adhesion and migration of microglia via GTPase Rho pathway in vitro by Yan, Jun, Zhou, Xiao, Guo, Jing-Jing, Mao, Lei, Wang, Yi-Jin, Sun, Jing, Sun, Li-Xin, Zhang, Lu-Yong, Zhou, Xin-Fu, Liao, Hong

“…J. Neurochem. (2012) 120, 721–731. Nogo‐66 is a 66‐amino‐acid‐residue extracellular domain of Nogo‐A, which plays a key role in inhibition neurite outgrowth of…”
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A panel of serum microRNAs as specific biomarkers for diagnosis of compound- and herb-induced liver injury in rats by Su, Yu-Wen, Chen, Xi, Jiang, Zhen-Zhou, Wang, Tao, Wang, Cheng, Zhang, Yun, Wen, Jing, Xue, Mei, Zhu, Dan, Zhang, Yue, Su, Yi-Jing, Xing, Tong-Yue, Zhang, Chen-Yu, Zhang, Lu-Yong

“…Drug-induced liver injury (DILI) has been a public, economic and pharmaceutical issue for many years. Enormous effort has been made for discovering and…”
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Podophyllotoxin, a medicinal agent of plant origin: past, present and future by GUERRAM, Mounia, JIANG, Zhen-Zhou, ZHANG, Lu-Yong

“…The aryltetralin-type lignan podophyllotoxin, the main agent present in the resin extracted from the rhizomes of different podophyllum species, possesses…”
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Activation of natural killer T cells contributes to triptolide-induced liver injury in mice by Wang, Xin-zhi, Xue, Ru-feng, Zhang, Shen-ye, Zheng, Ya-ting, Zhang, Lu-yong, Jiang, Zhen-zhou

“…Triptolide (TP) is the main active ingredient of Tripterygium wilfordii Hook.f, which has attracted great interest due to its promising efficacy for autoimmune…”
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Pharmacological evaluation of Alstonia scholaris: Anti-inflammatory and analgesic effects by Shang, Jian-Hua, Cai, Xiang-Hai, Feng, Tao, Zhao, Yun-Li, Wang, Jing-Kun, Zhang, Lu-Yong, Yan, Ming, Luo, Xiao-Dong

“…Alstonia scholaris (Apocynaceae) has been historically used in “dai” ethnopharmacy to treat chronic respiratory diseases. The leaf extract, developed as a…”
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Deoxypodophyllotoxin induces G2/M cell cycle arrest and apoptosis in SGC-7901 cells and inhibits tumor growth in vivo by Wang, Yu-Rong, Xu, Yuan, Jiang, Zhen-Zhou, Guerram, Mounia, Wang, Bin, Zhu, Xiong, Zhang, Lu-Yong

“…Deoxypodophyllotoxin (DPT), a natural microtubule destabilizer, was isolated from Anthriscus sylvestris, and a few studies have reported its anti-cancer…”
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Triptolide Induces Liver Injury by Regulating Macrophage Recruitment and Polarization via the Nrf2 Signaling Pathway by Liu, Li, Zhang, Xi, Xing, Xin, Mohammed, Ismail, Xu, Xiao-ting, Jiang, Zhen-zhou, Wang, Tao, Huang, Xin, Wang, Xin-zhi, Zhang, Lu-yong, Sun, Li-xin

“…Triptolide (TP) has limited usage in clinical practice due to its side effects and toxicity, especially liver injury. Hepatic macrophages, key player of liver…”
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Pyrazinamide Induced Rat Cholestatic Liver Injury through Inhibition of FXR Regulatory Effect on Bile Acid Synthesis and Transport by Guo, Hong-Li, Hassan, Hozeifa M, Zhang, Yun, Dong, Si-Zhe, Ding, Ping-Ping, Wang, Tao, Sun, Li-Xin, Zhang, Lu-Yong, Jiang, Zhen-Zhou

“…Pyrazinamide (PZA) is an indispensable first-line drug used for the treatment of tuberculosis which may cause serious hepatotoxicity; however, the mechanisms…”
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Tripterygium wilfordii multiglycoside-induced hepatotoxicity via inflammation and apoptosis in zebrafish by DUAN, Xiu-Ying, MA, Rui-Jiao, HSIAO, Chung-Der, JIANG, Zhen-Zhou, ZHANG, Lu-Yong, ZHANG, Yun, LIU, Ke-Chun

“…Tripterygium wilfordii multiglycoside (GTW) is a commonly used compound for the treatment of rheumatoid arthritis (RA) and immune diseases in clinical…”
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Poly(ether ester) and related block copolymers via organocatalytic ring‐opening polymerization by Li, Bo, Zhang, Yong‐Lu, Zhu, Xiao‐Feng, Li, Zhuo‐Qun, Li, Zi‐Hui, Qiu, Hua‐Yu, Wu, Guang‐Peng

“…Poly(p‐dioxanone) (PPDO) produced by ring‐opening polymerization (ROP) of p‐dioxanone (PDO) has been attracted intensive attention in bioengineering and…”
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Catalpol counteracts the pathology in a mouse model of Duchenne muscular dystrophy by inhibiting the TGF-β1/TAK1 signaling pathway by Xu, Deng-qiu, Zhao, Lei, Li, Si-jia, Huang, Xiao-fei, Li, Chun-jie, Sun, Li-xin, Li, Xi-hua, Zhang, Lu-yong, Jiang, Zhen-zhou

“…Duchenne muscular dystrophy (DMD) is a progressive neuromuscular disease caused by a mutation in the gene encoding the dystrophin protein. Catalpol is an…”
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Resveratrol effectively attenuates α-naphthyl- isothiocyanate-induced acute cholestasis and liver injury through choleretic and anti-inflammatory mechanisms by Wang, Tao, Zhou, Zhi-xing, Sun, Li-xin, Li, Xia, Xu, Zhi-meng, Chen, Mi, Zhao, Guo-lin, Jiang, Zhen-zhou, Zhang, Lu-yong

“…Aim： α-Naphthylisothiocyanate （ANIT） is a well-characterized cholestatic agent for rats. The aim of this study was to examine whether resveratrol could…”
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The natural product 4,10-aromadendranediol induces neuritogenesis in neuronal cells in vitro through activation of the ERK pathway by Chang, Sai, Ruan, Wen-chen, Xu, Ya-zhou, Wang, Yun-jie, Pang, Jie, Zhang, Lu-yong, Liao, Hong, Pang, Tao

“…Recent studies focus on promoting neurite outgrowth to remodel the central nervous network after brain injury. Currently, however, there are few drugs treating…”
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Toxic effects of triptolide on adrenal steroidogenesis in H295R cells and female rats by Xu, Ling‐Yan, Wu, Wei, Cheng, Rui, Sun, Li‐Xin, Jiang, Zhen‐Zhou, Zhang, Lu‐Yong, Zhang, Zun‐Jian, Su, Yu‐Wen, Huang, Xin

“…Triptolide (TP), a major active ingredient of Tripterygium wilfordii, exerts potent immunosuppressive effects in the treatment of rheumatoid arthritis but is…”
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Organic anion transporter 1 and 3 contribute to traditional Chinese medicine-induced nephrotoxicity by SHEN, Qing-Qing, WANG, Jing-Jing, ROY, Debmalya, SUN, Li-Xin, JIANG, Zhen-Zhou, ZHANG, Lu-Yong, HUANG, Xin

“…With the internationally growing popularity of traditional Chinese medicine (TCM), TCM-induced nephropathy has attracted public attention. Minimizing this…”
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