Search Results - "Zhang, Leike"

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro by Wang, Manli, Cao, Ruiyuan, Zhang, Leike, Yang, Xinglou, Liu, Jia, Xu, Mingyue, Shi, Zhengli, Hu, Zhihong, Zhong, Wu, Xiao, Gengfu

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Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur by Jin, Zhenming, Zhao, Yao, Sun, Yuan, Zhang, Bing, Wang, Haofeng, Wu, Yan, Zhu, Yan, Zhu, Chen, Hu, Tianyu, Du, Xiaoyu, Duan, Yinkai, Yu, Jing, Yang, Xiaobao, Yang, Xiuna, Yang, Kailin, Liu, Xiang, Guddat, Luke W., Xiao, Gengfu, Zhang, Leike, Yang, Haitao, Rao, Zihe

“…The antineoplastic drug carmofur is shown to inhibit the SARS-CoV-2 main protease (M pro ). Here, the X-ray crystal structure of M pro in complex with carmofur…”
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Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives by Amporndanai, Kangsa, Meng, Xiaoli, Shang, Weijuan, Jin, Zhenmig, Rogers, Michael, Zhao, Yao, Rao, Zihe, Liu, Zhi-Jie, Yang, Haitao, Zhang, Leike, O’Neill, Paul M., Samar Hasnain, S.

“…The SARS-CoV-2 pandemic has triggered global efforts to develop therapeutics. The main protease of SARS-CoV-2 (M pro ), critical for viral replication, is a…”
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Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease by Su, Haixia, Yao, Sheng, Zhao, Wenfeng, Zhang, Yumin, Liu, Jia, Shao, Qiang, Wang, Qingxing, Li, Minjun, Xie, Hang, Shang, Weijuan, Ke, Changqiang, Feng, Lu, Jiang, Xiangrui, Shen, Jingshan, Xiao, Gengfu, Jiang, Hualiang, Zhang, Leike, Ye, Yang, Xu, Yechun

“…The ongoing pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) urgently needs an effective…”
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Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin by Yin, Wanchao, Luan, Xiaodong, Li, Zhihai, Zhou, Ziwei, Wang, Qingxing, Gao, Minqi, Wang, Xiaoxi, Zhou, Fulai, Shi, Jingjing, You, Erli, Liu, Mingliang, Wang, Qingxia, Jiang, Yi, Jiang, Hualiang, Xiao, Gengfu, Zhang, Leike, Yu, Xuekui, Zhang, Shuyang, Eric Xu, H.

“…The COVID-19 pandemic caused by nonstop infections of SARS-CoV-2 has continued to ravage many countries worldwide. Here we report that suramin, a 100-year-old…”
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Screening of FDA-Approved Drugs for Inhibitors of Japanese Encephalitis Virus Infection by Wang, Shaobo, Liu, Yang, Guo, Jiao, Wang, Peilin, Zhang, Leike, Xiao, Gengfu, Wang, Wei

“…Japanese encephalitis virus (JEV), an arthropod-borne flavivirus, is a major cause of acute viral encephalitis in humans. No approved drug is available for the…”
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High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors by Zhao, Yao, Du, Xiaoyu, Duan, Yinkai, Pan, Xiaoyan, Sun, Yifang, You, Tian, Han, Lin, Jin, Zhenming, Shang, Weijuan, Yu, Jing, Guo, Hangtian, Liu, Qianying, Wu, Yan, Peng, Chao, Wang, Jun, Zhu, Chenghao, Yang, Xiuna, Yang, Kailin, Lei, Ying, Guddat, Luke W., Xu, Wenqing, Xiao, Gengfu, Sun, Lei, Zhang, Leike, Rao, Zihe, Yang, Haitao

“…A new coronavirus (SARS-CoV-2) has been identified as the etiologic agent for the COVID-19 outbreak. Currently, effective treatment options remain very limited…”
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Design and development of an oral remdesivir derivative VV116 against SARS-CoV-2 by Xie, Yuanchao, Yin, Wanchao, Zhang, Yumin, Shang, Weijuan, Wang, Zhen, Luan, Xiaodong, Tian, Guanghui, Aisa, Haji A., Xu, Yechun, Xiao, Gengfu, Li, Jia, Jiang, Hualiang, Zhang, Shuyang, Zhang, Leike, Xu, H. Eric, Shen, Jingshan

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Gallium maltolate has in vitro antiviral activity against SARS-CoV-2 and is a potential treatment for COVID-19 by Bernstein, Lawrence R, Zhang, Leike

“…Background Gallium has demonstrated strong anti-inflammatory activity in numerous animal studies, and has also demonstrated direct antiviral activity against…”
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Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV‑2 by Dai, Wenhao, Jochmans, Dirk, Xie, Hang, Yang, Hang, Li, Jian, Su, Haixia, Chang, Di, Wang, Jiang, Peng, Jingjing, Zhu, Lili, Nian, Yong, Hilgenfeld, Rolf, Jiang, Hualiang, Chen, Kaixian, Zhang, Leike, Xu, Yechun, Neyts, Johan, Liu, Hong

“…A novel series of peptidomimetic aldehydes was designed and synthesized to target 3C protease (3Cpro) of enterovirus 71 (EV71). Most of the compounds exhibited…”
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Research on optimal operation of cascade pumping stations based on an improved sparrow search algorithm by Wang, Xueni, Ma, Xiamin, Liu, Xiaolian, Zhang, Leike, Tian, Yu, Ye, Chen

“…Abstract For the low efficiency and large loss of cascade pumping stations, aiming to maximize system efficiency, an optimized scheduling model of cascade…”
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The metabolic responses to hepatitis B virus infection shed new light on pathogenesis and targets for treatment by Li, Hongde, Zhu, Wandi, Zhang, Leike, Lei, Hehua, Wu, Xiangyu, Guo, Lin, Chen, Xinwen, Wang, Yulan, Tang, Huiru

“…Chronic infection caused by the hepatitis B virus (HBV), is strongly associated with hepatitis, fatty liver and hepatocellular carcinoma. To investigate the…”
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Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2 by Xiong, Rui, Zhang, Leike, Li, Shiliang, Sun, Yuan, Ding, Minyi, Wang, Yong, Zhao, Yongliang, Wu, Yan, Shang, Weijuan, Jiang, Xiaming, Shan, Jiwei, Shen, Zihao, Tong, Yi, Xu, Liuxin, Chen, Yu, Liu, Yingle, Zou, Gang, Lavillete, Dimitri, Zhao, Zhenjiang, Wang, Rui, Zhu, Lili, Xiao, Gengfu, Lan, Ke, Li, Honglin, Xu, Ke

“…Emerging and re-emerging RNA viruses occasionally cause epidemics and pandemics worldwide, such as the on-going outbreak of the novel coronavirus SARS-CoV-2…”
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Screening and Identification of Lassa Virus Entry Inhibitors from an FDA-Approved Drug Library by Wang, Peilin, Liu, Yang, Zhang, Guangshun, Wang, Shaobo, Guo, Jiao, Cao, Junyuan, Jia, Xiaoying, Zhang, Leike, Xiao, Gengfu, Wang, Wei

“…Currently, there is no approved therapy to treat Lassa fever; therefore, repurposing of approved drugs will accelerate the development of a therapeutic…”
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Structure-based development and preclinical evaluation of the SARS-CoV-2 3C-like protease inhibitor simnotrelvir by Jiang, Xiangrui, Su, Haixia, Shang, Weijuan, Zhou, Feng, Zhang, Yan, Zhao, Wenfeng, Zhang, Qiumeng, Xie, Hang, Jiang, Lei, Nie, Tianqing, Yang, Feipu, Xiong, Muya, Huang, Xiaoxing, Li, Minjun, Chen, Ping, Peng, Shaoping, Xiao, Gengfu, Jiang, Hualiang, Tang, Renhong, Zhang, Leike, Shen, Jingshan, Xu, Yechun

“…The persistent pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants…”
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Ebola virus VP35 hijacks the PKA-CREB1 pathway for replication and pathogenesis by AKIP1 association by Zhu, Lin, Gao, Ting, Huang, Yi, Jin, Jing, Wang, Di, Zhang, Leike, Jin, Yanwen, Li, Ping, Hu, Yong, Wu, Yan, Liu, Hainan, Dong, Qincai, Wang, Guangfei, Zheng, Tong, Song, Caiwei, Bai, Yu, Zhang, Xun, Liu, Yaoning, Yang, Weihong, Xu, Ke, Zou, Gang, Zhao, Lei, Cao, Ruiyuan, Zhong, Wu, Xia, Xianzhu, Xiao, Gengfu, Liu, Xuan, Cao, Cheng

“…Ebola virus (EBOV), one of the deadliest viruses, is the cause of fatal Ebola virus disease (EVD). The underlying mechanism of viral replication and…”
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A parallel multi-objective optimization based on adaptive surrogate model for combined operation of multiple hydraulic facilities in water diversion project by Liu, Xiaolian, Liu, Zirong, Hou, Xiaopeng, Tian, Yu, Wang, Xueni, Zhang, Leike, Wang, Hao

“…ABSTRACT In a complex pressurized water diversion project (WDP), the combined optimal operation of multiple hydraulic facilities is computationally expensive…”
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Structure-based discovery of dual pathway inhibitors for SARS-CoV-2 entry by Wang, Haofeng, Yang, Qi, Liu, Xiaoce, Xu, Zili, Shao, Maolin, Li, Dongxu, Duan, Yinkai, Tang, Jielin, Yu, Xianqiang, Zhang, Yumin, Hao, Aihua, Wang, Yajie, Chen, Jie, Zhu, Chenghao, Guddat, Luke, Chen, Hongli, Zhang, Leike, Chen, Xinwen, Jiang, Biao, Sun, Lei, Rao, Zihe, Yang, Haitao

“…Since 2019, SARS-CoV-2 has evolved rapidly and gained resistance to multiple therapeutics targeting the virus. Development of host-directed antivirals offers…”
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Oral remdesivir derivative VV116 is a potent inhibitor of respiratory syncytial virus with efficacy in mouse model by Zhang, Ruxue, Zhang, Yumin, Zheng, Wei, Shang, Weijuan, Wu, Yan, Li, Ning, Xiong, Jun, Jiang, Hualiang, Shen, Jingshan, Xiao, Gengfu, Xie, Yuanchao, Zhang, Leike

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Research on optimal allocation of flow and head in cascade pumping stations based on Harris hawks optimization by Hou, Xiaopeng, Zhang, Leike, Liu, Xiaolian, Wang, Xueni, Tian, Yu, Deng, Xianyu, Ye, Chen

“…Abstract To address the problems of massive energy consumption and low operating efficiency in cascade pumping stations (CPSs), an optimized scheduling model…”
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