Search Results - "Zhang, Jinsan"

Proteasome inhibition boosts autophagic degradation of ubiquitinated-AGR2 and enhances the antitumor efficiency of bevacizumab by Wang, Dawei, Xu, Qingqing, Yuan, Quan, Jia, Mengqi, Niu, Huanmin, Liu, Xiaofei, Zhang, Jinsan, Young, Charles Yf, Yuan, Huiqing

“…Anterior gradient 2 (AGR2), a protein belonging to the protein disulfide isomerase (PDI) family, is overexpressed in multiple cancers and promotes angiogenesis…”
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The Characteristic of S100A7 Induction by the Hippo-YAP Pathway in Cervical and Glossopharyngeal Squamous Cell Carcinoma by Kong, Fei, Li, Yunguang, Hu, Enze, Wang, Rui, Wang, Junhao, Liu, Jin, Zhang, Jinsan, He, Dacheng, Xiao, Xueyuan

“…S100A7 is expressed in many squamous cell carcinomas (SCCs). Our previous study revealed that S100A7 was dramatically induced in several SCC cells and…”
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Thalidomide combined with low‐dose short‐term glucocorticoid in the treatment of critical Coronavirus Disease 2019 by Chen, Chengshui, Qi, Feng, Shi, Keqing, Li, Yuping, Li, Ji, Chen, Yongping, Pan, Jingye, Zhou, Tieli, Lin, Xiangyang, Zhang, Jinsan, Luo, Yongde, Li, Xiaokun, Xia, Jinglin

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Knockdown of AGR2 induces cellular senescence in prostate cancer cells by ZHONGYI HU, YUANYUAN GU, BO HAN, JINSAN ZHANG, ZUNLING LI, KELI TIAN, YOUNG, Charles Y. F, HUIQING YUAN

“…Anterior-gradient 2 (AGR2), overexpressed in many tumors including prostate cancer (PCa), is implicated in stimulation of cell proliferation, adhesion,…”
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Targeting Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension (BPD-PH): Potential Role of the FGF Signaling Pathway in the Development of the Pulmonary Vascular System by Chao, Cho-Ming, Chong, Lei, Chu, Xuran, Shrestha, Amit, Behnke, Judith, Ehrhardt, Harald, Zhang, Jinsan, Chen, Chengshui, Bellusci, Saverio

“…More than 50 years after the first description of Bronchopulmonary dysplasia (BPD) by Northway, this chronic lung disease affecting many preterm infants is…”
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Piperlongumine as a direct TrxR1 inhibitor with suppressive activity against gastric cancer by Zou, Peng, Xia, Yiqun, Ji, Jiansong, Chen, Weiqian, Zhang, Jinsan, Chen, Xi, Rajamanickam, Vinothkumar, Chen, Gaozhi, Wang, Zhe, Chen, Lingfeng, Wang, Yifeng, Yang, Shulin, Liang, Guang

“…Highlights • Piperlongumine directly binds TrxR1 in vitro and inactivates TrxR1 in human gastric cancer cells. • Stably overexpressing TrxR1 in SGC-7901 cells…”
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MUL1 identified as mitochondria-linked biomarker promoting cisplatin resistance in OC cells by Liu, Lixiao, Zou, Chengyang, Shen, Jingtian, Huang, Rong, Zhang, Fubin, Du, Yongming, Luo, Xishao, Yang, Aiwu, Zhang, Jinsan, Guan, Yutao, Yan, Xiaojian

“…•We successfully constructed a prognostic risk model that includes 2 mitochondria-related mRNAs, and we validated this model using the GSE 26712…”
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Endoplasmic reticulum stress-induced neuronal inflammatory response and apoptosis likely plays a key role in the development of diabetic encephalopathy by Wang, Zhouguang, Huang, Yan, Cheng, Yi, Tan, Yi, Wu, Fenzan, Wu, Jiamin, Shi, Hongxue, Zhang, Hongyu, Yu, Xichong, Gao, Hongchang, Lin, Li, Cai, Jun, Zhang, Jinsan, Li, Xiaokun, Cai, Lu, Xiao, Jian

“…We assumed that diabetic encephalopathy (DEP) may be induced by endoplasmic reticulum (ER)-mediated inflammation and apoptosis in central nervous system. To…”
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Design, synthesis and pharmacological evaluation of N4,N6-disubstituted pyrimidine-4,6-diamine derivatives as potent EGFR inhibitors in non-small cell lung cancer by Zhang, Yuan, Lv, Handeng, Luo, Lu, Xu, Yong, Pan, Yaqian, Wang, Yuewu, Lin, Han, Xiong, Jianhua, Guo, Ping, Zhang, Jinsan, Li, Xiaokun, Ye, Faqing

“…▪A novel series of 4, 6-disubstituted pyrimidines derivatives were designed, synthesized, and evaluated as epidermal growth factor receptor (EGFR) inhibitors…”
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Pro-metastatic activity of AGR2 interrupts angiogenesis target bevacizumab efficiency via direct interaction with VEGFA and activation of NF-κB pathway by Jia, Mengqi, Guo, Yanxia, Zhu, Deyu, Zhang, Nianzhao, Li, Lin, Jiang, Jin, Dong, Yiwen, Xu, Qingqing, Zhang, Xiulei, Wang, Meijuan, Yu, Haina, Wang, Fang, Tian, Keli, Zhang, Jinsan, Young, Charles Y.F., Lou, Hongxiang, Yuan, Huiqing

“…Anterior gradient 2 (AGR2), an endoplasmic reticulum (ER)-resident protein-disulfide isomerase (PDI), is associated with cancer development and malignant…”
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Highlighting fibroblast plasticity in lung fibrosis: the WI-38 cell line as a model for investigating the myofibroblast and lipofibroblast switch by Vásquez-Pacheco, Esmeralda, Marega, Manuela, Lingampally, Arun, Fassy, Julien, Truchi, Marin, Goth, Kerstin, Trygub, Lisa, Taghizadeh, Sara, Bartkuhn, Marek, Alexopoulos, Ioannis, Dong, Ying, Lebrigand, Kevin, Gunther, Andreas, Chen, Chengshui, Zhang, JinSan, Chao, Cho-Ming, Al Alam, Denise, El Agha, Elie, Mari, Bernard, Bellusci, Saverio, Rivetti, Stefano

“…Myofibroblasts (MYFs) are generally considered the principal culprits in excessive extracellular matrix deposition and scar formation in the pathogenesis of…”
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Restricted Heterochromatin Formation Links NFATc2 Repressor Activity With Growth Promotion in Pancreatic Cancer by Baumgart, Sandra, Glesel, Elisabeth, Singh, Garima, Chen, Nai–Ming, Reutlinger, Kristina, Zhang, Jinsan, Billadeau, Daniel D, Fernandez–Zapico, Martin E, Gress, Thomas M, Singh, Shiv K, Ellenrieder, Volker

“…Background & Aims Transcriptional silencing of the p15INK4b tumor suppressor pathway overcomes cellular protection against unrestrained proliferation in…”
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Depletion of CABYR-a/b sensitizes lung cancer cells to TRAIL-induced apoptosis through YAP/p73-mediated DR5 upregulation by Xiao, Qianqian, Qian, Zunlei, Zhang, Weiqing, Liu, Jin, Hu, Enze, Zhang, Jinsan, Li, Mingying, Wang, Junhao, Kong, Fei, Li, Yunguang, Wang, Rui, Tan, Xiaohua, He, Dacheng, Xiao, Xueyuan

“…Our previous study revealed that knockdown of CABYR-a/b increases the chemosensitivity of lung cancer cells through inactivation of Akt. Here, we demonstrated…”
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Targeting Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension by Chao, Cho-Ming, Chong, Lei, Chu, Xuran, Shrestha, Amit, Behnke, Judith, Ehrhardt, Harald, Zhang, Jinsan, Chen, Chengshui, Bellusci, Saverio

“…More than 50 years after the first description of Bronchopulmonary dysplasia (BPD) by Northway, this chronic lung disease affecting many preterm infants is…”
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Detailed Structural-Functional Analysis of the Krüppel-like Factor 16 (KLF16) Transcription Factor Reveals Novel Mechanisms for Silencing Sp/KLF Sites Involved in Metabolism and Endocrinology by Daftary, Gaurang S., Lomberk, Gwen A., Buttar, Navtej S., Allen, Thomas W., Grzenda, Adrienne, Zhang, Jinsan, Zheng, Ye, Mathison, Angela J., Gada, Ravi P., Calvo, Ezequiel, Iovanna, Juan L., Billadeau, Daniel D., Prendergast, Franklyn G., Urrutia, Raul

“…Krüppel-like factor (KLF) proteins have elicited significant attention due to their emerging key role in metabolic and endocrine diseases. Here, we extend this…”
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Design, synthesis, and biological evaluation of 3-vinyl-quinoxalin-2(1H)-one derivatives as novel antitumor inhibitors of FGFR1 by Liu, Zhiguo, Yu, Shufang, Chen, Di, Shen, Guoliang, Wang, Yu, Hou, Leping, Lin, Dan, Zhang, Jinsan, Ye, Faqing

“…FGFR1 is well known as a molecular target in anticancer drug design. TKI258 plays an important role in RTK inhibitors. Utilizing TKI258 as a lead compound that…”
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Design, synthesis, and biological evaluation of 3-vinyl-quinoxalin-2 by Wang, Yu, Hou, Leping, Chen, Di, Lin, Dan, Shen, Guoliang, Zhang, Jinsan, Ye, Faqing, Yu, Shufang, Liu, Zhiguo

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Nuclear factor of activated T-cells c1 integrates STAT3 signals to link chronic inflammation and carcinogenesis in the pancreas by Baumgart, Sandra, Chen, Nai-ming, Brunner, Marius, Johanna, Reinecke, Nikorowitsch, Julius, Singh, Shiv, König, Alexander, Zhang, Jinsan, Wolf, Elmar, Bartkuhn, Marek, Siveke, Jens, Esposito, Irene, Glesel, Elisabeth, Geisel, Bettina, Reutlinger, Kristina, Singh, Garima, Eilers, Martin, Gress, Thomas, Billadeau, Daniel, Ellenrieder, Volker

“…[...]high correlative nuclear expression levels of NFATc1 and active STAT3 were detected in the majority of human and murine cancer tissues…”
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