Search Results - "Zhang, Jessie"

Assembly of a Rovibrational Ground State Molecule in an Optical Tweezer by Cairncross, William B, Zhang, Jessie T, Picard, Lewis R B, Yu, Yichao, Wang, Kenneth, Ni, Kang-Kuen

“…We demonstrate the coherent creation of a single NaCs molecule in its rotational, vibrational, and electronic (rovibronic) ground state in an optical tweezer…”
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Forming a Single Molecule by Magnetoassociation in an Optical Tweezer by Zhang, Jessie T., Yu, Yichao, Cairncross, William B., Wang, Kenneth, Picard, Lewis R. B., Hood, Jonathan D., Lin, Yen-Wei, Hutson, Jeremy M., Ni, Kang-Kuen

“…We demonstrate the formation of a single NaCs molecule in an optical tweezer by magnetoassociation through an s -wave Feshbach resonance at 864.11(5) G…”
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Increasing Reduction Potentials of Type 1 Copper Center and Catalytic Efficiency of Small Laccase from Streptomyces coelicolor through Secondary Coordination Sphere Mutations by Wang, Jing‐Xiang, Vilbert, Avery C., Cui, Chang, Mirts, Evan N., Williams, Lucas H., Kim, Wantae, Jessie Zhang, Y., Lu, Yi

“…The key to type 1 copper (T1Cu) function lies in the fine tuning of the CuII/I reduction potential (E°′T1Cu) to match those of its redox partners, enabling…”
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Modern approaches to improving phase contrast electron microscopy by Axelrod, Jeremy J., Zhang, Jessie T., Petrov, Petar N., Glaeser, Robert M., Müller, Holger

“…Although defocus can be used to generate partial phase contrast in transmission electron microscope images, cryo-electron microscopy (cryo-EM) can be further…”
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Variation of C-terminal domain governs RNA polymerase II genomic locations and alternative splicing in eukaryotic transcription by Zhang, Qian, Kim, Wantae, Panina, Svetlana B., Mayfield, Joshua E., Portz, Bede, Zhang, Y. Jessie

“…The C-terminal domain of RPB1 (CTD) orchestrates transcription by recruiting regulators to RNA Pol II upon phosphorylation. With CTD driving condensate…”
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Visible Light Mediated Bidirectional Control over Carbonic Anhydrase Activity in Cells and in Vivo Using Azobenzenesulfonamides by Aggarwal, Kanchan, Kuka, Timothy P, Banik, Mandira, Medellin, Brenda P, Ngo, Chinh Q, Xie, Da, Fernandes, Yohaan, Dangerfield, Tyler L, Ye, Elva, Bouley, Bailey, Johnson, Kenneth A, Zhang, Yan Jessie, Eberhart, Johann K, Que, Emily L

“…Two azobenzenesulfonamide molecules with thermally stable cis configurations resulting from fluorination of positions ortho to the azo group are reported that…”
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Tracking Inhibition of Human Small C‑Terminal Domain Phosphatase 1 Using 193 nm Ultraviolet Photodissociation Mass Spectrometry by Escobar, Edwin E., Yang, Wanjie, Lanzillotti, Michael B., Juetten, Kyle J., Shields, Samuel, Siegel, Dionicio, Zhang, Y. Jessie, Brodbelt, Jennifer S.

“…Working in tandem with kinases via a dynamic interplay of phosphorylation and dephosphorylation of proteins, phosphatases regulate many cellular processes and…”
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Phasor histone FLIM-FRET microscopy quantifies spatiotemporal rearrangement of chromatin architecture during the DNA damage response by Lou, Jieqiong, Scipioni, Lorenzo, Wright, Belinda K., Bartolec, Tara K., Zhang, Jessie, Masamsetti, V. Pragathi, Gaus, Katharina, Gratton, Enrico, Cesare, Anthony J., Hinde, Elizabeth

“…To investigate how chromatin architecture is spatiotemporally organized at a double-strand break (DSB) repair locus, we established a biophysical method to…”
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Extended Rotational Coherence of Polar Molecules in an Elliptically Polarized Trap by Park, Annie J., Picard, Lewis R. B., Patenotte, Gabriel E., Zhang, Jessie T., Rosenband, Till, Ni, Kang-Kuen

“…We demonstrate long rotational coherence of individual polar molecules in the motional ground state of an optical trap. In the present, previously unexplored…”
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Cryo-EM phase-plate images reveal unexpected levels of apparent specimen damage by Remis, Jonathan, Petrov, Petar N., Zhang, Jessie T., Axelrod, Jeremy J., Cheng, Hang, Sandhaus, Shahar, Mueller, Holger, Glaeser, Robert M.

“…[Display omitted] •Phase plates recover low-frequency information with significantly improved SNR.•Laser phase-plate images reveal unexpected amounts of…”
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Biosensor and machine learning-aided engineering of an amaryllidaceae enzyme by d’Oelsnitz, Simon, Diaz, Daniel J., Kim, Wantae, Acosta, Daniel J., Dangerfield, Tyler L., Schechter, Mason W., Minus, Matthew B., Howard, James R., Do, Hannah, Loy, James M., Alper, Hal S., Zhang, Y. Jessie, Ellington, Andrew D.

“…A major challenge to achieving industry-scale biomanufacturing of therapeutic alkaloids is the slow process of biocatalyst engineering. Amaryllidaceae…”
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Introduction of Asymmetry in the Fused 4‑Oxalocrotonate Tautomerases by Erwin, Kaci, Moreno, R. Yvette, Baas, Bert-Jan, Zhang, Y. Jessie, Whitman, Christian P.

“…Members of the 4-oxalocrotonate tautomerase (4-OT) subgroup in the tautomerase superfamily (TSF) are constructed from a single β–α–β unit and form homo- or…”
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Reduction of TMEM97 increases NPC1 protein levels and restores cholesterol trafficking in Niemann-pick type C1 disease cells by Ebrahimi-Fakhari, Darius, Wahlster, Lara, Bartz, Fabian, Werenbeck-Ueding, Jennifer, Praggastis, Maria, Zhang, Jessie, Joggerst-Thomalla, Brigitte, Theiss, Susanne, Grimm, Dirk, Ory, Daniel S, Runz, Heiko

“…Niemann-Pick type C disease (NP-C) is a progressive lysosomal lipid storage disease caused by mutations in the NPC1 and NPC2 genes. NPC1 is essential for…”
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Overcoming resolution loss due to thermal magnetic field fluctuations from phase plates in transmission electron microscopy by Axelrod, Jeremy J., Petrov, Petar N., Zhang, Jessie T., Remis, Jonathan, Buijsse, Bart, Glaeser, Robert M., Mȕller, Holger

“…•Electrically conductive materials cause thermal magnetic field fluctuations.•Thermal magnetic field fluctuations from a laser phase plate causes resolution…”
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Death-Associated Protein Kinase 1 Phosphorylates Pin1 and Inhibits Its Prolyl Isomerase Activity and Cellular Function by Lee, Tae Ho, Chen, Chun-Hau, Suizu, Futoshi, Huang, Pengyu, Schiene-Fischer, Cordelia, Daum, Sebastian, Zhang, Yan Jessie, Goate, Alison, Chen, Ruey-Hwa, Zhou, Xiao Zhen, Lu, Kun Ping

“…Pin1 is a phospho-specific prolyl isomerase that regulates numerous key signaling molecules and whose deregulation contributes to disease notably cancer…”
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Targeting of REST with rationally-designed small molecule compounds exhibits synergetic therapeutic potential in human glioblastoma cells by Panina, Svetlana B, Schweer, Joshua V, Zhang, Qian, Raina, Gaurav, Hardtke, Haley A, Kim, Seungjin, Yang, Wanjie, Siegel, Dionicio, Zhang, Y Jessie

“…Glioblastoma (GBM) is an aggressive brain cancer associated with poor prognosis, intrinsic heterogeneity, plasticity, and therapy resistance. In some GBMs,…”
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A murine Niemann-Pick C1 I1061T knock-in model recapitulates the pathological features of the most prevalent human disease allele by Praggastis, Maria, Tortelli, Brett, Zhang, Jessie, Fujiwara, Hideji, Sidhu, Rohini, Chacko, Anita, Chen, Zhouji, Chung, Chan, Lieberman, Andrew P, Sikora, Jakub, Davidson, Cristin, Walkley, Steven U, Pipalia, Nina H, Maxfield, Frederick R, Schaffer, Jean E, Ory, Daniel S

“…Niemann-Pick Type C1 (NPC1) disease is a rare neurovisceral, cholesterol-sphingolipid lysosomal storage disorder characterized by ataxia, motor impairment,…”
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A sensitive and specific LC-MS/MS method for rapid diagnosis of Niemann-Pick C1 disease from human plasma[S] by Jiang, Xuntian, Sidhu, Rohini, Porter, Forbes D., Yanjanin, Nicole M., Speak, Anneliese O., te Vruchte, Danielle Taylor, Platt, Frances M., Fujiwara, Hideji, Scherrer, David E., Zhang, Jessie, Dietzen, Dennis J., Schaffer, Jean E., Ory, Daniel S.

“…Niemann-Pick type C1 (NPC1) disease is a rare, progressively fatal neurodegenerative disease for which there are no FDA-approved therapies. A major barrier to…”
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The Activators of Cyclin-Dependent Kinase 5 p35 and p39 Are Essential for Oligodendrocyte Maturation, Process Formation, and Myelination by Luo, Fucheng, Zhang, Jessie, Burke, Kathryn, Miller, Robert H, Yang, Yan

“…The regulation of oligodendrocyte development and myelin formation in the CNS is poorly defined. Multiple signals influence the rate and extent of CNS…”
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Coherent Optical Creation of a Single Molecule by Yu, Yichao, Wang, Kenneth, Hood, Jonathan D., Picard, Lewis R. B., Zhang, Jessie T., Cairncross, William B., Hutson, Jeremy M., Gonzalez-Ferez, Rosario, Rosenband, Till, Ni, Kang-Kuen

“…We report coherent association of atoms into a single weakly bound NaCs molecule in an optical tweezer through an optical Raman transition. The Raman technique…”
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