Search Results - "Zhang, Houbin"

Leukemia Inhibitory Factor Protects against Degeneration of Cone Photoreceptors Caused by RPE65 Deficiency by Dong, Shuqian, Zhen, Fangyuan, Zou, Tongdan, Zhou, Yongwei, Wu, Jiahui, Wang, Ting, Zhang, Houbin

“…Retinal pigment epithelium (RPE) 65 is a key enzyme in the visual cycle involved in the regeneration of 11-cis-retinal. Mutations in the human RPE65 gene cause…”
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Rhodopsin-associated retinal dystrophy: Disease mechanisms and therapeutic strategies by Zhen, Fangyuan, Zou, Tongdan, Wang, Ting, Zhou, Yongwei, Dong, Shuqian, Zhang, Houbin

“…Rhodopsin is a light-sensitive G protein-coupled receptor that initiates the phototransduction cascade in rod photoreceptors. Mutations in the…”
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Mistrafficking of prenylated proteins causes retinitis pigmentosa 2 by Zhang, Houbin, Hanke‐Gogokhia, Christin, Jiang, Li, Li, Xiaobo, Wang, Pu, Gerstner, Cecilia D., Frederick, Jeanne M., Yang, Zhenglin, Baehr, Wolfgang

“…The retinitis pigmentosa 2 polypeptide (RP2) functions as a GTPase‐activating protein (GAP) for ARL3 (Arf‐like protein 3), a small GTPase. ARL3 is an effector…”
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Cholesterol homeostasis regulated by ABCA1 is critical for retinal ganglion cell survival by Yang, Jialiang, Chen, Yuhong, Zou, Tongdan, Xue, Bai, Yang, Fang, Wang, Xiangzhou, Huo, Yibo, Yan, Boyun, Xu, Yuxia, He, Shiyu, Yin, Yi, Wang, Jing, Zhu, Xiong, Zhang, Lin, Zhou, Yu, Tai, Zhengfu, Shuai, Ping, Yu, Man, Luo, Qian, Cheng, Yilian, Gong, Bo, Zhu, Xianjun, Zhang, Jing, Sun, Xinghuai, Lin, Ying, Zhang, Houbin, Yang, Zhenglin

“…Genome-wide association studies have suggested a link between primary open-angle glaucoma and the function of ABCA1. ABCA1 is a key regulator of cholesterol…”
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A quick protocol for the preparation of mouse retinal cryosections for immunohistochemistry by Yang, Jialiang, Zou, Tongdan, Yang, Fang, Zhang, Zilong, Sun, Chen, Yang, Zhenglin, Zhang, Houbin

“…Immunohistochemistry (IHC) using mouse retinal cryosections is widely used to study the expression and intracellular localization of proteins in mouse retinas…”
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Deep Sc-RNA sequencing decoding the molecular dynamic architecture of the human retina by Huang, Lulin, Li, Runze, Ye, Lin, Zhang, Shanshan, Tian, Huaping, Du, Mingyan, Qu, Chao, Li, Shujin, Li, Jie, Yang, Mu, Wu, Biao, Chen, Ran, Huang, Guo, Zhong, Ling, Yang, Hongjie, Yu, Man, Shi, Yi, Wang, Changguan, Zhang, Houbin, Chen, Wei, Yang, Zhenglin

“…The human retina serves as a light detector and signals transmission tissue. Advanced insights into retinal disease mechanisms and therapeutic strategies…”
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Redundant and unique roles of retinol dehydrogenases in the mouse retina by Maeda, Akiko, Maeda, Tadao, Sun, Wenyu, Zhang, Houbin, Baehr, Wolfgang, Palczewski, Krzysztof

“…Highly abundant short-chain alcohol dehydrogenases (RDHs) in the retina were assumed to be involved in the recycling of 11-cis-retinal chromophore in the…”
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Erratum to: Cholesterol homeostasis regulated by ABCA1 is critical for retinal ganglion cell survival by Yang, Jialiang, Chen, Yuhong, Zou, Tongdan, Xue, Bai, Yang, Fang, Wang, Xiangzhou, Huo, Yibo, Yan, Boyun, Xu, Yuxia, He, Shiyu, Yin, Yi, Wang, Jing, Zhu, Xiong, Zhang, Lin, Zhou, Yu, Tai, Zhengfu, Shuai, Ping, Yu, Man, Luo, Qian, Cheng, Yilian, Gong, Bo, Zhu, Xianjun, Zhang, Jing, Sun, Xinghuai, Lin, Ying, Zhang, Houbin, Yang, Zhenglin

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An improved method for preparation of mouse retinal cryosections by Li, Ling, Lin, Yongqiong, Yang, Fang, Zou, Tongdan, Yang, Jialiang, Zhang, Houbin

“…Immunohistochemistry using mouse retinal cryosections is a routine assay used in vision research. However, retinal tissues are fragile, and it is difficult to…”
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Mutant RAMP2 causes primary open-angle glaucoma via the CRLR-cAMP axis by Gong, Bo, Zhang, Houbin, Huang, Lulin, Chen, Yuhong, Shi, Yi, Tam, Pancy Oi-Sin, Zhu, Xianjun, Huang, Yi, Lei, Bo, Sundaresan, Periasamy, Li, Xi, Jiang, Linxin, Yang, Jialiang, Lin, Ying, Lu, Fang, Chen, Lijia, Li, Yuanfeng, Leung, Christopher Kai-Shun, Guo, Xiaoxin, Zhang, Shanshan, Huang, Guo, Wu, Yaqi, Zhou, Tongdan, Shuai, Ping, Tham, Clement Chee-Yung, Weisschuh, Nicole, Krishnadas, Subbaiah Ramasamy, Mardin, Christian, Reis, André, Yang, Jiyun, Zhang, Lin, Zhou, Yu, Wang, Ziyan, Qu, Chao, Shaw, Peter X., Pang, Chi-Pui, Sun, Xinghuai, Zhu, Weiquan, Li, Dean Yaw, Pasutto, Francesca, Yang, Zhenglin

“…Purpose Primary open-angle glaucoma (POAG) is the leading cause of irreversible blindness worldwide and mutations in known genes can only explain 5–6% of POAG…”
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Whole-exome Sequencing Analysis Identifies Mutations in the EYS Gene in Retinitis Pigmentosa in the Indian Population by Di, Yanan, Huang, Lulin, Sundaresan, Periasamy, Li, Shujin, Kim, Ramasamy, Ballav Saikia, Bibhuti, Qu, Chao, Zhu, Xiong, Zhou, Yu, Jiang, Zhilin, Zhang, Lin, Lin, Ying, Zhang, Dingding, Li, Yuanfen, Zhang, Houbin, Yin, Yibing, Lu, Fang, Zhu, Xianjun, Yang, Zhenglin

“…Retinitis pigmentosa (RP) is a rare heterogeneous genetic retinal dystrophy disease and despite years of research, known genetic mutations can explain only…”
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Trafficking of Membrane-Associated Proteins to Cone Photoreceptor Outer Segments Requires the Chromophore 11-cis-Retinal by Zhang, Houbin, Fan, Jie, Li, Sha, Karan, Sukanya, Rohrer, Baerbel, Palczewski, Krzysztof, Frederick, Jeanne M, Crouch, Rosalie K, Baehr, Wolfgang

“…Lecithin retinol acyl transferase (LRAT) and retinal pigment epithelium protein 65 (RPE65) are key enzymes of the retinoid cycle. In Lrat(-/-) and Rpe65(-/-)…”
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Long-term RNA interference gene therapy in a dominant retinitis pigmentosa mouse model by Jiang, Li, Zhang, Houbin, Dizhoor, Alexander M, Boye, Shannon E, Hauswirth, William W, Frederick, Jeanne M, Baehr, Wolfgang

“…RNA interference (RNAi) gene silencing is a potential therapeutic strategy for dominant retinal degeneration disorders. We used self-complementary (sc) AAV2/8…”
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A novel missense variant in cathepsin C gene leads to PLS in a Chinese patient: A case report and literature review by Yu, Hui, He, Xun, Liu, Xiangqin, Zhang, Houbin, Shen, Zhu, Shi, Yi, Liu, Xiaoqi

“…Background Papilon‐Lefevre syndrome (PLS; OMIM 245000) is a rare autosomal recessive disease characterized by aggressive periodontitis and palmoplantar…”
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Role of Photoreceptor-specific Retinol Dehydrogenase in the Retinoid Cycle in Vivo by Maeda, Akiko, Maeda, Tadao, Imanishi, Yoshikazu, Kuksa, Vladimir, Alekseev, Andrei, Bronson, J. Darin, Zhang, Houbin, Zhu, Li, Sun, Wenyu, Saperstein, David A., Rieke, Fred, Baehr, Wolfgang, Palczewski, Krzysztof

“…The retinoid cycle is a recycling system that replenishes the 11-cis-retinal chromophore of rhodopsin and cone pigments. Photoreceptor-specific retinol…”
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Retinitis Pigmentosa: Disease Mechanisms, Diagnosis, and Therapies by Shu, Xinhua, Pang, Ji-jing, Zhang, Houbin, Mansfield, David

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Exome Sequencing Identified a Recessive RDH12 Mutation in a Family with Severe Early-Onset Retinitis Pigmentosa by Zhang, Dingding, Wang, Le, Zhang, Houbin, Hao, Fang, Zhou, Yu, Yang, Yin, Li, Xiulan, Hao, Jilong, Huang, Lulin, Wei, Bo, Gong, Bo, Cui, Zhihua

“…Retinitis pigmentosa (RP) is the most important hereditary retinal disease caused by progressive degeneration of the photoreceptor cells. This study is to…”
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Identification and Light-Dependent Translocation of a Cone-Specific Antigen, Cone Arrestin, Recognized by Monoclonal Antibody 7G6 by Zhang, Houbin, Cuenca, Nicolas, Ivanova, Tamara, Church-Kopish, Jill, Frederick, Jeanne M, MacLeish, Peter R, Baehr, Wolfgang

“…To elucidate the antigen recognized by monoclonal antibody (mAb) 7G6, a widely used cone-specific marker. 7G6 immunocytochemistry was performed on sections of…”
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Towards an improved analytical framework to estimate active earth pressure in narrow c – ϕ soils behind rotating walls about the base by Lai, Fengwen, Yang, Dayu, Liu, Songyu, Zhang, Houbin, Cheng, Yuehong

“…Retaining walls are sometimes unavoidably constructed near existing stabilized structures to maintain stability of narrow retained c-ϕ soils. Although some…”
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LncRNA SLC9A3-AS1 knockdown increases the sensitivity of liver cancer cell to triptolide by regulating miR-449b-5p-mediated glycolysis by Zhao, Lei, Zhang, Houbin, Ren, Peiyou, Sun, Xiangjun

“…Triptolide (TP) is involved in the progression of liver cancer. However, the detailed molecular network regulated through TP is still unclear. Long non-coding…”
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