Search Results - "Zhang, H. Steve"

Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations by Soldner, Frank, Laganière, Josée, Cheng, Albert W., Hockemeyer, Dirk, Gao, Qing, Alagappan, Raaji, Khurana, Vikram, Golbe, Lawrence I., Myers, Richard H., Lindquist, Susan, Zhang, Lei, Guschin, Dmitry, Fong, Lauren K., Vu, B. Joseph, Meng, Xiangdong, Urnov, Fyodor D., Rebar, Edward J., Gregory, Philip D., Zhang, H. Steve, Jaenisch, Rudolf

“…Patient-specific induced pluripotent stem cells (iPSCs) derived from somatic cells provide a unique tool for the study of human disease, as well as a promising…”
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LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: Reversal by gene correction by Sanders, Laurie H, Laganière, Josée, Cooper, Oliver, Mak, Sally K, Vu, B. Joseph, Huang, Y. Anne, Paschon, David E, Vangipuram, Malini, Sundararajan, Ramya, Urnov, Fyodor D, Langston, J. William, Gregory, Philip D, Zhang, H. Steve, Greenamyre, J. Timothy, Isacson, Ole, Schüle, Birgitt

“…Abstract Parkinson's disease associated mutations in leucine rich repeat kinase 2 ( LRRK2 ) impair mitochondrial function and increase the vulnerability of…”
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An engineered zinc finger protein activator of the endogenous glial cell line-derived neurotrophic factor gene provides functional neuroprotection in a rat model of Parkinson's disease by Laganiere, Josee, Kells, Adrian P, Lai, Jeffrey T, Guschin, Dmitry, Paschon, David E, Meng, Xiangdong, Fong, Lauren K, Yu, Qi, Rebar, Edward J, Gregory, Philip D, Bankiewicz, Krystof S, Forsayeth, John, Zhang, H Steve

“…Loss of dopaminergic neurons is primarily responsible for the onset and progression of Parkinson's disease (PD); thus, neuroprotective and/or neuroregenerative…”
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A Designed Zinc-finger Transcriptional Repressor of Phospholamban Improves Function of the Failing Heart by Zhang, H Steve, Liu, Dingang, Huang, Yan, Schmidt, Stefan, Hickey, Reed, Guschin, Dmitry, Su, Haili, Jovin, Ion S, Kunis, Mike, Hinkley, Sarah, Liang, Yuxin, Hinh, Linda, Spratt, S Kaye, Case, Casey C, Rebar, Edward J, Ehrlich, Barbara, Gregory, Philip D, Giordano, Frank J

“…Selective inhibition of disease-related proteins underpins the majority of successful drug–target interactions. However, development of effective antagonists…”
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Genome editing with engineered zinc finger nucleases by Gregory, Philip D, Urnov, Fyodor D, Rebar, Edward J, Holmes, Michael C, Zhang, H. Steve

“…Key Points Targeted genetic engineering in many important model systems and in human tissue culture cells has historically been challenging. This has changed…”
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A TALE nuclease architecture for efficient genome editing by Rebar, Edward J, Miller, Jeffrey C, Tan, Siyuan, Qiao, Guijuan, Barlow, Kyle A, Wang, Jianbin, Xia, Danny F, Meng, Xiangdong, Paschon, David E, Leung, Elo, Hinkley, Sarah J, Dulay, Gladys P, Hua, Kevin L, Ankoudinova, Irina, Cost, Gregory J, Urnov, Fyodor D, Zhang, H Steve, Holmes, Michael C, Zhang, Lei, Gregory, Philip D

“…TALEs (transcription activator-like effectors) are transcription factors from the plant pathogen Xanthomonas that can be readily engineered to bind new DNA…”
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Transduction of striatum and cortex tissues by adeno-associated viral vectors produced by herpes simplex virus- and baculovirus-based methods by Zhang, H. Steve, Kim, Eunmi, Lee, Slgirim, Ahn, Ik-Sung, Jang, Jae-Hyung

“…► We examined the in vivo performances of rAAV2 packaged with different methods. ► Different packaging methods caused no changes in in vivo performances of…”
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Locus-specific epigenetic remodeling controls addiction- and depression-related behaviors by Heller, Elizabeth A, Cates, Hannah M, Peña, Catherine J, Sun, Haosheng, Shao, Ningyi, Feng, Jian, Golden, Sam A, Herman, James P, Walsh, Jessica J, Mazei-Robison, Michelle, Ferguson, Deveroux, Knight, Scott, Gerber, Mark A, Nievera, Christian, Han, Ming-Hu, Russo, Scott J, Tamminga, Carol S, Neve, Rachael L, Shen, Li, Zhang, H Steve, Zhang, Feng, Nestler, Eric J

“…The authors selectively modify chromatin in a specific gene in vivo to examine the link between chromatin dynamics and drug- and stress-evoked responses. They…”
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Persistent repression of tau in the brain using engineered zinc finger protein transcription factors by Wegmann, Susanne, DeVos, Sarah L, Zeitler, Bryan, Marlen, Kimberly, Bennett, Rachel E, Perez-Rando, Marta, MacKenzie, Danny, Yu, Qi, Commins, Caitlin, Bannon, Riley N, Corjuc, Bianca T, Chase, Alison, Diez, Lisa, Nguyen, Hoang-Oanh B, Hinkley, Sarah, Zhang, Lei, Goodwin, Alicia, Ledeboer, Annemarie, Lam, Stephen, Ankoudinova, Irina, Tran, Hung, Scarlott, Nicholas, Amora, Rainier, Surosky, Richard, Miller, Jeffrey C, Robbins, Ashley B, Rebar, Edward J, Urnov, Fyodor D, Holmes, Michael C, Pooler, Amy M, Riley, Brigit, Zhang, H Steve, Hyman, Bradley T

“…Neuronal tau reduction confers resilience against β-amyloid and tau-related neurotoxicity in vitro and in vivo. Here, we introduce a novel translational…”
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Ocular Gene Transfer with Self-Complementary AAV Vectors by Yokoi, Katsutoshi, Kachi, Shu, Zhang, H. Steve, Gregory, Philip D, Spratt, S. Kaye, Samulski, R. Jude, Campochiaro, Peter A

“…Self-complementary AAV (scAAV) vectors have been developed to circumvent rate-limiting second-strand synthesis in single-stranded AAV vector genomes and to…”
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Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations by Soldner, Frank, Laganière, Josée, Cheng, Albert W., Hockemeyer, Dirk, Gao, Qing, Alagappan, Raaji, Khurana, Vikram, Golbe, Lawrence I., Myers, Richard H., Lindquist, Susan, Zhang, Lei, Guschin, Dmitry, Fong, Lauren K., Vu, B. Joseph, Meng, Xiangdong, Urnov, Fyodor D., Rebar, Edward J., Gregory, Philip D., Zhang, H. Steve, Jaenisch, Rudolf

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Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington’s disease by Zeitler, Bryan, Froelich, Steven, Marlen, Kimberly, Shivak, David A, Yu, Qi, Li, Davis, Pearl, Jocelynn R, Miller, Jeffrey C, Zhang, Lei, Paschon, David E, Hinkley, Sarah J, Ankoudinova, Irina, Lam, Stephen, Guschin, Dmitry, Kopan, Lexi, Cherone, Jennifer M, Nguyen, Hoang-Oanh B, Qiao, Guijuan, Ataei, Yasaman, Mendel, Matthew C, Amora, Rainier, Surosky, Richard, Laganiere, Josee, Vu, B Joseph, Narayanan, Anand, Sedaghat, Yalda, Tillack, Karsten, Thiede, Christina, Gärtner, Annette, Kwak, Seung, Bard, Jonathan, Mrzljak, Ladislav, Park, Larry, Heikkinen, Taneli, Lehtimäki, Kimmo K, Svedberg, Marie M, Häggkvist, Jenny, Tari, Lenke, Tóth, Miklós, Varrone, Andrea, Halldin, Christer, Kudwa, Andrea E, Ramboz, Sylvie, Day, Michelle, Kondapalli, Jyothisri, Surmeier, D James, Urnov, Fyodor D, Gregory, Philip D, Rebar, Edward J, Muñoz-Sanjuán, Ignacio, Zhang, H Steve

“…Huntington’s disease (HD) is a dominantly inherited neurodegenerative disorder caused by a CAG trinucleotide expansion in the huntingtin gene ( HTT ), which…”
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Axonal transport of AAV9 in nonhuman primate brain by Green, F, Samaranch, L, Zhang, H S, Manning-Bog, A, Meyer, K, Forsayeth, J, Bankiewicz, K S

“…A pilot study in nonhuman primates was conducted, in which two Rhesus macaques received bilateral parenchymal infusions of adeno-associated virus serotype 9…”
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A7 Drug discovery approach for rare neurological diseases: using novel zinc finger protein technology to develop potential therapy for huntington’s disease by Chiocco, Matthew, Choi, Vivian, Graham, Anne-Renee, Klatte, Debra, Francone, Omar, Thomson, David, Zeitler, Bryan, Froelich, Steven, Yu, Qi, Paschon, David E, Miller, Jeffrey C, Marlen, Kimberly, Rebar, Edward J, Urnov, Fyodor D, Gregory, Philip D, Steve Zhang, H

“…There are approximately 7000 known rare and orphan diseases, over a third of which affect the central nervous system, virtually all do not have adequate…”
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A Designed Zinc-finger Transcriptional Repressor of Phospholamban Improves Function of the Failing Heart

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649. Repression of Vascular Endothelial Growth Factor-A Over-Expression in Glioblastoma Cells Using Engineered Zinc-Finger Transcription Factors by Snowden, Andrew W, Zhang, Lei, Urnov, Fyodor, Dent, Carolyn, Mcnamara, Andrew R, Jouvenot, Yann, Zhang, Steve H, Rebar, Edward J, Jamieson, Andrew C, Case, Casey C, Gregory, Philip D

“…Angiogenesis is of critical importance to tumor progression and therefore is an attractive target in the treatment of cancer. The pro-angiogenic Vascular…”
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