Search Results - "Zhang, Geoff Y."

Antigen Specific Regulatory T Cells in Kidney Transplantation and Other Tolerance Settings by Hu, Min, Rogers, Natasha M, Li, Jennifer, Zhang, Geoff Y, Wang, Yuan Min, Shaw, Karli, O'Connell, Philip J, Alexander, Stephen I

“…Kidney transplantation is the most common solid organ transplant and the best current therapy for end-stage kidney failure. However, with standard…”
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Patient and Graft Survival Following Kidney Transplantation in Recipients With Cystinosis: A Cohort Study by Spicer, Rebecca A., MBChB, Clayton, Philip A., MBBS, PhD, McTaggart, Steven J., MBBS, PhD, Zhang, Geoff Y., MD, MMed, Alexander, Stephen I., MBBS, MPH

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Bilateral Wilms Tumor and Early Presentation in Pediatric Patients Is Associated with the Truncation of the Wilms Tumor 1 Protein by Hu, Min, MD, PhD, Fletcher, Jeffery, MBBS, BSc, FRACP, PhD, McCahon, Emma, MBBS, FRACP, MBA, Catchpoole, Daniel, PhD, Zhang, Geoff Y., MD, Wang, Yuan Min, MD, PhD, Algar, Elizabeth M., PhD, Alexander, Stephen I., MBBS, MPH, FRACP

“…Objectives To investigate the frequency of constitutional Wilms tumor 1 gene ( WT1 ) abnormalities in children with bilateral Wilms tumor (WT) and the age of…”
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Regulatory T cells in kidney disease and transplantation by Hu, Min, Wang, Yuan Min, Wang, Yiping, Zhang, Geoff Y, Zheng, Guoping, Yi, Shounan, O'Connell, Philip J, Harris, David C H, Alexander, Stephen I

“…Regulatory T cells (Tregs) have been shown to be important in maintaining immune homeostasis and preventing autoimmune disease, including autoimmune kidney…”
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Absence of MyD88 Signaling Induces Donor-Specific Kidney Allograft Tolerance by HUILING WU, NOORDMANS, Gerda A, O'BRIEN, Maya R, JIN MA, ZHAO, Cathy Y, ZHANG, Geoff Y, KWAN, Tony K. T, ALEXANDER, Stephen I, CHADBAN, Steven J

“…Toll-like receptors (TLRs) play a fundamental role in innate immunity and provide a link between innate and adaptive responses to an allograft; however,…”
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Low-Dose IL-2 In Vivo Treg Expansion Limits Rejection in Corneal Grafting by Zhang, Geoff Y, Hu, Min, Wang, Yuan Min, Alexander, Stephen I

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Intragraft memory-like CD127hiCD4+Foxp3+ Tregs maintain transplant tolerance by Zhao, Yuanfei, Nicholson, Leigh, Wang, Hannah, Qian, Yi Wen, Hawthorne, Wayne J, Jimenez-Vera, Elvira, Gloss, Brian S, Lai, Joey, Thomas, Adwin, Chew, Yi Vee, Burns, Heather, Zhang, Geoff Y, Wang, Yuan Min, Rogers, Natasha M, Zheng, Guoping, Yi, Shounan, Alexander, Stephen I, O'Connell, Philip J, Hu, Min

“…CD4+Foxp3+ regulatory T cells (Tregs) play an essential role in suppressing transplant rejection, but their role within the graft and heterogeneity in…”
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Methyl-Guanine-Methyl-Transferase Transgenic Bone Marrow Transplantation Allows N,N-bis(2-chloroethyl)-Nitrosourea Driven Donor Mixed-Chimerism Without Graft-Versus-Host Disease, and With Donor-Specific Allograft Tolerance by Hu, Min, Kramer, Belinda, Zhang, Geoff Y, Wang, Yuan Min, Watson, Debbie, Howden, Brian, McCowage, Geoff, Alexander, Ian E, Gunning, Peter, Alexander, Stephen I

“…BACKGROUNDTransplant tolerance has been achieved by mixed chimerism in animal models and in a limited number of kidney transplant patients. However, these…”
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Long-Term Cardiac Allograft Survival across an MHC Mismatch after "Pruning" of Alloreactive CD4 T Cells by Hu, Min, Watson, Debbie, Zhang, Geoff Y, Graf, Nicole, Wang, Yuan M, Sartor, Mary, Howden, Brian, Fletcher, Jeffrey, Alexander, Stephen I

“…Specific tolerance to allografts has been achieved by a variety of means. We have previously shown that ex vivo removal of dividing CD4(+) T cells from an MLR…”
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Foxp3 as a marker of tolerance induction versus rejection by Zhang, Geoff Y, Hu, Min, Wang, Yuan Min, Alexander, Stephen I

“…Foxp3 is the transcription factor that induces the regulatory T cell phenotype. This review will examine issues around Foxp3 induction and function as well as…”
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Tolerance induction by removal of alloreactive T cells: in-vivo and pruning strategies by Watson, Debbie, Hu, Min, Zhang, Geoff Y, Wang, Yuan Min, Alexander, Stephen I

“…Current depletion strategies used in clinical transplantation can prevent acute rejection of a transplanted organ; however, they are nonspecific and are…”
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Prophylactic bilateral nephrectomies in two paediatric patients with missense mutations in the WT1 gene by Hu, Min, Zhang, Geoff Y., Arbuckle, Susan, Graf, Nicole, Shun, Albert, Silink, Martin, Lewis, Deborah, Alexander, Stephen I.

“…Background. Denys–Drash syndrome (DDS) is associated with mutations of the Wilms’ tumour 1 (WT1) gene, and is characterized by pseudohermaphroditism, a…”
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Robust anti-tumor immunity and memory in Rag-1-deficient mice following adoptive transfer of cytokine-primed splenocytes and tumor CD80 expression by Ganesan, Priyadarshini L, Alexander, Stephen I, Watson, Debbie, Logan, Grant J, Zhang, Geoff Y, Alexander, Ian E

“…Successful immunotherapy of solid tumors has proven difficult to achieve. The aim of the current study was to further investigate the effects of peripheral…”
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Matching T‐Cell Receptors Identified in Renal Biopsies and Urine at the Time of Acute Rejection in Pediatric Renal Transplant Patients by Hu, Min, Zhang, Geoff Y., Walters, Giles, Sartor, Mary, Watson, Debbie, Knight, John F., Alexander, Stephen I.

“…Urinary monitoring of kidney allograft function has been used for many years. More recently, molecular identification of cytotoxic T‐cell products has been…”
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T cell receptor BV gene usage in interstitial cellular infiltrates in active Heymann nephritis by Wu, Huiling, Zhang, Geoff Y., Knight, John F.

“…Background. Infiltration of the kidney by mononuclear cells is a prominent feature of active Heymann nephritis (HN). These cells could be present as a part of…”
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106.4: A novel subset of memory-like CD127highCD4+FOXP3+Treg found in porcine neonatal islet cell cluster (NICC) xenotransplant tolerant mice share similar features with tissue Tregs by Wang, Haina, Wang, Zhuangzi, Zhao, Yuanfei, Nicholson, Leigh, Hawthorne, Wayne J, Jimenez-vera, Elvira, Gloss, Brian, Lai, Joey, Thomas, Adwin, Zhang, Geoff Y, Wang, Yuan Min, Rogers, Natasha, Zheng, Guoping, Yi, Shounan, Alexander, Stephen I, O’Connell, Philip J, Hu, Min

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414.9: Shared Transcriptional Trajectory of Tissue Tregs Between Tolerant-Grafts and Lymphoid Organs in Transplant Tolerance by Wang, Haina, Wang, Zhuangzi, Zhao, Yuanfei, Nicholson, Leigh, Hawthorne, Wayne J, Jimenez-vera, Elvira, Gloss, Brian, Lai, Joey, Thomas, Adwin, Zhang, Geoff Y, Min Wang, Yuan, Rogers, Natasha, Zheng, Guoping, Yi, Shounan, Alexander, Stephen I, O’Connell, Philip J, Hu, Min

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Foxp3-transduced polyclonal regulatory T cells protect against chronic renal injury from adriamycin by YUAN MIN WANG, YU ZHANG, Geoff, YIPING WANG, MIN HU, HUILING WU, WATSON, Debbie, HORI, Shohei, ALEXANDER, Ian E, HARRIS, David C. H, ALEXANDER, Stephen I

“…Chronic proteinuric renal injury is a major cause of ESRD. Adriamycin nephropathy is a murine model of chronic proteinuric renal disease whereby chemical…”
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IL-2/IL-2Ab Complexes Induce Regulatory T Cell Expansion and Protect against Proteinuric CKD by POLHILL, Tania, GEOFF YU ZHANG, SPRENT, Jonathan, HARRIS, David C. H, ALEXANDER, Stephen I, YUAN MIN WANG, MIN HU, SAWYER, Andrew, JIMMY JIANHENG ZHOU, SAITO, Mitsuru, WEBSTER, Kylie E, YA WANG, YIPING WANG, GREY, Shane T

“…Regulatory T cells (Tregs) help protect against autoimmune renal injury. The use of agonist antibodies and antibody/cytokine combinations to expand Tregs in…”
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CD8+ Regulatory T Cells Induced by T Cell Vaccination Protect Against Autoimmune Nephritis by YUAN MIN WANG, GEOFF YU ZHANG, WANG, Xin Maggie, YIPING WANG, HARRIS, David C. H, ALEXANDER, Stephen I, MIN HU, POLHILL, Tania, SAWYER, Andrew, JIANHENG ZHOU, Jimmy, SAITO, Mitsuru, WATSON, Debbie, HUILING WU, YA WANG

“…Autoreactive T cells play a pivotal role in the pathogenesis of autoimmune kidney disease. T cell vaccination (TCV) may limit autoimmune disease and induce…”
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