Search Results - "Zhang, Fang‐Lin"

Functionalization of C(sp³)-H bonds using a transient directing group by Zhang, Fang-Lin, Hong, Kai, Li, Tuan-Jie, Park, Hojoon, Yu, Jin-Quan

“…Proximity-driven metalation has been extensively exploited to achieve reactivity and selectivity in carbon–hydrogen (C–H) bond activation. Despite the…”
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Targeting Chromatin-Remodeling Factors in Cancer Cells: Promising Molecules in Cancer Therapy by Zhang, Fang-Lin, Li, Da-Qiang

“…ATP-dependent chromatin-remodeling complexes can reorganize and remodel chromatin and thereby act as important regulator in various cellular processes. Based…”
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Copper-mediated synthesis of N-arylated cyclic urea from diaminecarbamate by Liu, Handong, Wang, Yeming, Lu, Xuelian, Sun, Bing, Gong, Qingge, Zhang, Fang-Lin

“…[Display omitted] A convenient base-promoted CuI-mediated intermolecular synthesis of N-arylated cyclic ureas from diaminecarbamate and aryl iodides was…”
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Diverse ortho-C(sp2)–H Functionalization of Benzaldehydes Using Transient Directing Groups by Liu, Xi-Hai, Park, Hojoon, Hu, Jun-Hao, Hu, Yan, Zhang, Qun-Liang, Wang, Bao-Long, Sun, Bing, Yeung, Kap-Sun, Zhang, Fang-Lin, Yu, Jin-Quan

“…Pd-catalyzed C–H functionalizations promoted by transient directing groups remain largely limited to C–H arylation only. Herein, we report a diverse set of…”
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O-GlcNAcylation of MORC2 at threonine 556 by OGT couples TGF-β signaling to breast cancer progression by Liu, Ying-Ying, Liu, Hong-Yi, Yu, Tian-Jian, Lu, Qin, Zhang, Fang-Lin, Liu, Guang-Yu, Shao, Zhi-Ming, Li, Da-Qiang

“…MORC family CW-type zinc finger 2 (MORC2) is a newly identified chromatin-remodeling enzyme involved in DNA damage response and gene transcription, and its…”
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Monodentate Transient Directing Group Enabled Pd-Catalyzed Ortho-C–H Methoxylation and Chlorination of Benzaldehydes by Li, Feng, Zhou, Yirong, Yang, Heng, Wang, Ziqi, Yu, Qinqin, Zhang, Fang-Lin

“…We report Pd-catalyzed ortho-C–H methoxylation and chlorination of benzaldehydes by employing monodentate transient directing groups (TDGs) as an alternative…”
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Cancer-Associated MORC2-Mutant M276I Regulates an hnRNPM-Mediated CD44 Splicing Switch to Promote Invasion and Metastasis in Triple-Negative Breast Cancer by Zhang, Fang-Lin, Cao, Jin-Ling, Xie, Hong-Yan, Sun, Rui, Yang, Li-Feng, Shao, Zhi-Ming, Li, Da-Qiang

“…Triple-negative breast cancer (TNBC) is the most lethal subtype of breast cancer, with a high propensity for distant metastasis and limited treatment options,…”
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FBXO22 Possesses Both Protumorigenic and Antimetastatic Roles in Breast Cancer Progression by Sun, Rui, Xie, Hong-Yan, Qian, Jin-Xian, Huang, Yan-Ni, Yang, Fan, Zhang, Fang-Lin, Shao, Zhi-Min, Li, Da-Qiang

“…The molecular underpinnings behind malignant progression of breast cancer from a localized lesion to an invasive and ultimately metastatic disease are…”
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Palladium-Catalyzed Direct Ortho-C–H Selenylation of Benzaldehydes Using Benzidine as a Transient Directing Group by Qiao, Huihao, Sun, Bing, Yu, Qinqin, Huang, Yi-Yong, Zhou, Yirong, Zhang, Fang-Lin

“…Benzidine was found to be a novel transient directing group to enable Pd-catalyzed direct selenylation of inert C­(sp2)–H bonds of benzaldehydes. Diverse…”
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Synthesis of Polycyclic Aromatic Hydrocarbons (PAHs) via a Transient Directing Group by Tang, Ming, Yu, Qinqin, Wang, Ziqi, Zhang, Chen, Sun, Bing, Yi, Ying, Zhang, Fang-Lin

“…In this work, an efficient synthetic route was developed to construct PAHs with diverse shape, width, and edge topology. The precursors of PAHs were obtained…”
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Synthesis of Polycyclic Spiro Pyrrolidone Derivatives via DBU‐Catalyzed Diastereoselective Vinylogous Aldol‐Michael Cascade Reaction by Liu, Dandan, Wang, Jiansheng, Liu, Wenqin, Zhang, Fang‐Lin, Zhou, Yirong

“…A new DBU‐catalyzed vinylogous aldol‐Michael cascade strategy was developed for highly efficient construction of polycyclic heterocycles bearing a spiro…”
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RNF144A functions as a tumor suppressor in breast cancer through ubiquitin ligase activity-dependent regulation of stability and oncogenic functions of HSPA2 by Yang, Yin-Long, Zhang, Ye, Li, Dou-Dou, Zhang, Fang-Lin, Liu, Hong-Yi, Liao, Xiao-Hong, Xie, Hong-Yan, Lu, Qin, Zhang, Lin, Hong, Qi, Dong, Wen-Jie, Li, Da-Qiang, Shao, Zhi-Min

“…Deregulation of E3 ubiquitin ligases is intimately implicated in breast cancer pathogenesis and progression, but the underlying mechanisms still remain…”
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DBU‐Promoted Intramolecular Crossed Aldol Reaction: A Facile Access to Indane‐Fused Pyrrolidine by Yang, Heng, Liu, Dandan, Yu, Qinqin, Xia, Siyu, Yu, Dan, Zhang, Mao, Sun, Bing, Zhang, Fang‐Lin

“…A new strategy for the facile synthesis of indane‐fused pyrrolidines through DBU‐promoted intramolecular crossed aldol reaction has been developed. The…”
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Poly(ADP-ribosyl)ation of acetyltransferase NAT10 by PARP1 is required for its nucleoplasmic translocation and function in response to DNA damage by Liu, Hong-Yi, Liu, Ying-Ying, Zhang, Yin-Ling, Ning, Yan, Zhang, Fang-Lin, Li, Da-Qiang

“…Abstract Background N-acetyltransferase 10 (NAT10), an abundant nucleolar protein with both lysine and RNA cytidine acetyltransferase activities, has been…”
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Cascade reaction for the synthesis of polycyclic aromatic hydrocarbons via transient directing group strategy by Wang, Ziqi, Dong, Wendan, Sun, Bing, Yu, Qinqin, Zhang, Fang-Lin

“…A Pd(II)-catalyzed cascade synthesis of diverse polycyclic aromatic hydrocarbons via transient directing group strategy has been developed, involving the…”
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Spermatid perinuclear RNA-binding protein promotes UBR5-mediated proteolysis of Dicer to accelerate triple-negative breast cancer progression by Chen, Si-Yu, Zhang, Fang-Lin, Zhang, Yin-Ling, Liao, Li, Deng, Ling, Shao, Zhi-Min, Liu, Guang-Yu, Li, Da-Qiang

“…Triple-negative breast cancer (TNBC) is the most lethal subtype of breast cancer with no targeted therapy. Spermatid perinuclear RNA binding protein (STRBP), a…”
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ETHE1 Accelerates Triple-Negative Breast Cancer Metastasis by Activating GCN2/eIF2α/ATF4 Signaling by Yang, Shao-Ying, Liao, Li, Hu, Shu-Yuan, Deng, Ling, Andriani, Lisa, Zhang, Tai-Mei, Zhang, Yin-Ling, Ma, Xiao-Yan, Zhang, Fang-Lin, Liu, Ying-Ying, Li, Da-Qiang

“…Triple-negative breast cancer (TNBC) is the most fatal subtype of breast cancer; however, effective treatment strategies for TNBC are lacking. Therefore, it is…”
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HIF‐1α promotes the proliferation and migration of pulmonary arterial smooth muscle cells via activation of Cx43 by Han, Xiao‐Jian, Zhang, Wei‐Fang, Wang, Qin, Li, Min, Zhang, Chun‐Bo, Yang, Zhang‐Jian, Tan, Ren‐Jie, Gan, Li‐Jun, Zhang, Le‐Ling, Lan, Xue‐Mei, Zhang, Fang‐Lin, Hong, Tao, Jiang, Li‐Ping

“…The proliferation of pulmonary artery smooth muscle cells (PASMCs) is an important cause of pulmonary vascular remodelling in hypoxia‐induced pulmonary…”
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USP9X stabilizes BRCA1 and confers resistance to DNA‐damaging agents in human cancer cells by Lu, Qin, Zhang, Fang‐Lin, Lu, Da‐Yun, Shao, Zhi‐Ming, Li, Da-Qiang

“…BRCA1, a multifunctional protein with an important role in DNA double‐strand break repair by homologous recombination (HR), is subjected to ubiquitin‐dependent…”
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Chromatin complexes subunit BAP18 promotes triple-negative breast cancer progression through transcriptional activation of oncogene S100A9 by Zhang, Yin-Ling, Deng, Ling, Liao, Li, Yang, Shao-Ying, Hu, Shu-Yuan, Ning, Yan, Zhang, Fang-Lin, Li, Da-Qiang

“…Triple-negative breast cancer (TNBC) is a highly lethal disease due to aggressive clinical phenotype and the lack of validated therapeutic targets. Our recent…”
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