Comorbid Medical Conditions as Predictors of Overall Survival in Glioblastoma Patients

Comorbid Medical Conditions as Predictors of Overall Survival in Glioblastoma Patients

Glioblastoma (GBM) is an aggressive central nervous system tumor with a poor prognosis. This study was conducted to determine any comorbid medical conditions that are associated with survival in GBM. Data were collected from medical records of all patients who presented to VCU Medical Center with GB...

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Bibliographic Details
Published in:Scientific reports Vol. 9; no. 1; pp. 20018 - 8
Main Authors: Carr, Matthew T., Hochheimer, Camille J., Rock, Andrew K., Dincer, Alper, Ravindra, Lakshmi, Zhang, Fan Lily, Opalak, Charles F., Poulos, Nora, Sima, Adam P., Broaddus, William C.
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 27-12-2019
Nature Publishing Group
Subjects:
692/4028/546
692/617/375/1922
692/700/1750
Aged
Asthma
Biopsy
Brain cancer
Brain Neoplasms - complications
Brain Neoplasms - pathology
Central nervous system
Comorbidity
Female
Glioblastoma
Glioblastoma - complications
Glioblastoma - pathology
Humanities and Social Sciences
Humans
Hypercholesterolemia
Male
Medical prognosis
Medical records
Middle Aged
Mortality risk
multidisciplinary
Patients
Proportional Hazards Models
Retrospective Studies
Science
Science (multidisciplinary)
Surgery
Survival
Survival Analysis
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Summary:Glioblastoma (GBM) is an aggressive central nervous system tumor with a poor prognosis. This study was conducted to determine any comorbid medical conditions that are associated with survival in GBM. Data were collected from medical records of all patients who presented to VCU Medical Center with GBM between January 2005 and February 2015. Patients who underwent surgery/biopsy were considered for inclusion. Cox proportional hazards regression modeling was performed to assess the relationship between survival and sex, race, and comorbid medical conditions. 163 patients met inclusion criteria. Comorbidities associated with survival on individual-characteristic analysis included: history of asthma (Hazard Ratio [HR]: 2.63; 95% Confidence Interval [CI]: 1.24–5.58; p = 0.01), hypercholesterolemia (HR: 1.95; 95% CI: 1.09–3.50; p = 0.02), and incontinence (HR: 2.29; 95% CI: 0.95–5.57; p = 0.07). History of asthma (HR: 2.22; 95% CI: 1.02–4.83; p = 0.04) and hypercholesterolemia (HR: 1.99; 95% CI: 1.11–3.56; p = 0.02) were associated with shorter survival on multivariable analysis. Surgical patients with GBM who had a prior history of asthma or hypercholesterolemia had significantly higher relative risk for mortality on individual-characteristic and multivariable analyses.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-56574-w