Search Results - "Zhang, Erik Y"

Inhibition of the mechanistic target of rapamycin induces cell survival via MAPK in tuberous sclerosis complex by Lu, Yiyang, Zhang, Erik Y, Liu, Jie, Yu, Jane J

“…Tuberous sclerosis complex (TSC) is a genetic disorder that cause tumors to form in many organs. These lesions may lead to epilepsy, autism, developmental…”
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Connectivity Map Analysis of a Single-Cell RNA-Sequencing -Derived Transcriptional Signature of mTOR Signaling by Al Mahi, Naim, Zhang, Erik Y, Sherman, Susan, Yu, Jane J, Medvedovic, Mario

“…In the connectivity map (CMap) approach to drug repositioning and development, transcriptional signature of disease is constructed by differential gene…”
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Upregulation of acid ceramidase contributes to tumor progression in tuberous sclerosis complex by Astrinidis, Aristotelis, Li, Chenggang, Zhang, Erik Y, Zhao, Xueheng, Zhao, Shuyang, Guo, Minzhe, Olatoke, Tasnim, Mattam, Ushodaya, Huang, Rong, Zhang, Alan G, Pitstick, Lori, Kopras, Elizabeth J, Gupta, Nishant, Jandarov, Roman, Smith, Eric P, Fugate, Elizabeth, Lindquist, Diana, Markiewski, Maciej M, Karbowniczek, Magdalena, Wikenheiser-Brokamp, Kathryn A, Setchell, Kenneth D R, McCormack, Francis X, Xu, Yan, Yu, Jane J

“…Tuberous sclerosis complex (TSC) is characterized by multisystem, low-grade neoplasia involving the lung, kidneys, brain, and heart. Lymphangioleiomyomatosis…”
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Rapamycin-resistant poly (ADP-ribose) polymerase-1 overexpression is a potential therapeutic target in lymphangioleiomyomatosis by Sun, Yang, Gallacchi, Dana, Zhang, Erik Y, Reynolds, Samuel B, Robinson, Lauren, Malinowska, Izabela A, Chiou, Terry T, Pereira, Ana M, Li, Chenggang, Kwiatkowski, David J, Lee, Po-Shun, Yu, Jane J

“…Lymphangioleiomyomatosis (LAM) is a female-predominant cystic lung disease that can lead to respiratory failure. LAM cells typically have inactivating tuberous…”
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Single-Cell Transcriptomic Analysis Identifies a Unique Pulmonary Lymphangioleiomyomatosis Cell by Guo, Minzhe, Yu, Jane J, Perl, Anne Karina, Wikenheiser-Brokamp, Kathryn A, Riccetti, Matt, Zhang, Erik Y, Sudha, Parvathi, Adam, Mike, Potter, Andrew, Kopras, Elizabeth J, Giannikou, Krinio, Potter, S Steven, Sherman, Sue, Hammes, Stephen R, Kwiatkowski, David J, Whitsett, Jeffrey A, McCormack, Francis X, Xu, Yan

“…Lymphangioleiomyomatosis (LAM) is a metastatic neoplasm of reproductive-age women associated with mutations in tuberous sclerosis complex genes. LAM causes…”
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Activation of choline kinase drives aberrant choline metabolism in esophageal squamous cell carcinomas by Ma, Wang, Wang, Shuangyuan, Zhang, Tengfei, Zhang, Erik Y., Zhou, Lina, Hu, Chunxiu, Yu, Jane J., Xu, Guowang

“…•A global metabolomic approach for biomarkers and mechanisms in ESCC is proposed.•ESCC patient have significantly different metabolites profiles than health…”
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Rapalog resistance is associated with mesenchymal-type changes in Tsc2-null cells by Valianou, Matthildi, Filippidou, Natalia, Johnson, Daniel L., Vogel, Peter, Zhang, Erik Y., Liu, Xiaolei, Lu, Yiyang, Yu, Jane J., Bissler, John J., Astrinidis, Aristotelis

“…Tuberous Sclerosis Complex (TSC) and Lymphangioleiomyomatosis (LAM) are caused by inactivating mutations in TSC1 or TSC2 , leading to mTORC1 hyperactivation…”
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Proapoptotic protein Bim attenuates estrogen-enhanced survival in lymphangioleiomyomatosis by Li, Chenggang, Li, Na, Liu, Xiaolei, Zhang, Erik Y, Sun, Yang, Masuda, Kouhei, Li, Jing, Sun, Julia, Morrison, Tasha, Li, Xiangke, Chen, Yuanguang, Wang, Jiang, Karim, Nagla A, Zhang, Yi, Blenis, John, Reginato, Mauricio J, Henske, Elizabeth P, Yu, Jane J

“…Lymphangioleiomyomatosis (LAM) is a progressive lung disease that primarily affects young women. Genetic evidence suggests that LAM cells bearing mutations…”
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Single-cell multiomic analysis identifies a HOX-PBX gene network regulating the survival of lymphangioleiomyomatosis cells by Olatoke, Tasnim, Wagner, Andrew, Astrinidis, Aristotelis, Zhang, Erik Y, Guo, Minzhe, Zhang, Alan G, Mattam, Ushodaya, Kopras, Elizabeth J, Gupta, Nishant, Smith, Eric P, Karbowniczek, Magdalena, Markiewski, Maciej M, Wikenheiser-Brokamp, Kathryn A, Whitsett, Jeffrey A, McCormack, Francis X, Xu, Yan, Yu, Jane J

“…Lymphangioleiomyomatosis (LAM) is a rare, progressive lung disease that predominantly affects women. LAM cells carry mutations, causing mTORC1 hyperactivation…”
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Smooth Muscle Hypertrophy Following Partial Bladder Outlet Obstruction Is Associated with Overexpression of Non-Muscle Caldesmon by Zhang, Erik Y., Stein, Raimund, Chang, Shaohua, Zheng, Yongmu, Zderic, Stephen A., Wein, Alan J., Chacko, Samuel

“…Partial bladder outlet obstruction (PBOO) induces remodeling of urinary bladder smooth muscle (detrusor). We demonstrate an increase in bladder wall mass,…”
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