Treatment of Brachioradial Pruritus: A Tertiary Center Retrospective Analysis

This retrospective study investigates the efficacy of 2 treatment regimens, pregabalin alone versus pregabalin combined with ketamine, amitriptyline, and lidocaine cream, in reducing itch in patients with brachioradial pruritus at a tertiary care center. Electronic medical records of 64 brachioradia...

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Bibliographic Details
Published in:	Acta dermato-venereologica Vol. 104; p. adv40246
Main Authors:	Mashoudy, Kayla D, Andrade, Luis F, Khalil, Nicole, Zhang, Ellie H, Wagner, Jaxon D, Malhotra, Bharat, Yosipovitch, Gil
Format:	Journal Article
Language:	English
Published:	Sweden MJS Publishing, on behalf of the Society for Publication of Acta Dermato-Venereologica 25-06-2024 Medical Journals Sweden
Subjects:	Administration, Cutaneous Adult Aged Amitriptyline - adverse effects Amitriptyline - therapeutic use Antipruritics - adverse effects Antipruritics - therapeutic use brachioradial pruritus Drug Therapy, Combination Electronic Health Records Female Florida Humans Ketamine - administration & dosage Ketamine - adverse effects Ketamine - therapeutic use Lidocaine - administration & dosage Lidocaine - therapeutic use Male Middle Aged neuropathic pruritus Original Report Pregabalin - therapeutic use pruritus Pruritus - drug therapy Pruritus - etiology Retrospective Studies Skin Cream Tertiary Care Centers Treatment Outcome treatments Florida
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Summary:	This retrospective study investigates the efficacy of 2 treatment regimens, pregabalin alone versus pregabalin combined with ketamine, amitriptyline, and lidocaine cream, in reducing itch in patients with brachioradial pruritus at a tertiary care center. Electronic medical records of 64 brachioradial pruritus patients seen at the University of Miami Itch Center were analyzed. A significant reduction in itch scores was seen with both treatments, with no significant difference between the groups. A small number of patients experienced adverse effects, including drowsiness and weight gain with pregabalin and skin irritation with ketamine, amitriptyline, and lidocaine cream. Ultimately, our findings underscore the potential of utilizing combined therapy for difficult-to-treat brachioradial pruritus cases and implementing individualized approaches for managing neuropathic pruritus. Further controlled clinical trials are needed to establish optimal treatment protocols.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0001-5555 1651-2057 1651-2057
DOI:	10.2340/actadv.v104.40246