Search Results - "Zhang, Donna D"

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis by Dodson, Matthew, Castro-Portuguez, Raul, Zhang, Donna D

“…The transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) is a key regulator of the cellular antioxidant response, controlling the expression…”
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The emerging role of the Nrf2-Keap1 signaling pathway in cancer by Jaramillo, Melba C, Zhang, Donna D

“…The Nrf2 (nuclear factor erythroid 2 [NF-E2]-related factor 2 [Nrf2])-Keap1 (Kelch-like erythroid cell-derived protein with CNC homology [ECH]-associated…”
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Breakdown of an Ironclad Defense System: The Critical Role of NRF2 in Mediating Ferroptosis by Anandhan, Annadurai, Dodson, Matthew, Schmidlin, Cody J, Liu, Pengfei, Zhang, Donna D

“…Ferroptosis is a non-apoptotic mode of regulated cell death that is iron and lipid peroxidation dependent. As new mechanistic insight into ferroptotic…”
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The Nrf2-Keap1-ARE signaling pathway: The regulation and dual function of Nrf2 in cancer by Zhang, Donna D

“…The NF-E2-related factor-2 (Nrf2) is a transcription factor that is ubiquitously expressed at low levels in all human organs. As Nrf2 regulates a major…”
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Mechanistic Studies of the Nrf2-Keap1 Signaling Pathway by Zhang, Donna D.

“…Since eukaryotic cells constantly encounter various environmental insults, they have evolved defense mechanisms to cope with toxicant- and carcinogen-induced…”
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USP22 Antagonizes p53 Transcriptional Activation by Deubiquitinating Sirt1 to Suppress Cell Apoptosis and Is Required for Mouse Embryonic Development by Lin, Zhenghong, Yang, Heeyoung, Kong, Qingfei, Li, Jinping, Lee, Sang-Myeong, Gao, Beixue, Dong, Hongxin, Wei, Jianjun, Song, Jianxun, Zhang, Donna D., Fang, Deyu

“…The NAD-dependent histone deacetylase Sirt1 antagonizes p53 transcriptional activity to regulate cell-cycle progression and apoptosis. We have identified a…”
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Modulating NRF2 in Disease: Timing Is Everything by Dodson, Matthew, de la Vega, Montserrat Rojo, Cholanians, Aram B, Schmidlin, Cody J, Chapman, Eli, Zhang, Donna D

“…The transcription factor nuclear factor erythroid 2 (NF-E2)-related factor 2 (NRF2) is a central regulator of redox, metabolic, and protein homeostasis that…”
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Phosphorylation of Nrf2 at multiple sites by MAP kinases has a limited contribution in modulating the Nrf2-dependent antioxidant response by Sun, Zheng, Huang, Zheping, Zhang, Donna D

“…The bZIP transcription factor Nrf2 has emerged as a pivotal regulator of intracellular redox homeostasis by controlling the expression of many endogenous…”
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Oncogenic KRAS confers chemoresistance by upregulating NRF2 by Tao, Shasha, Wang, Shue, Moghaddam, Seyed Javad, Ooi, Aikseng, Chapman, Eli, Wong, Pak K, Zhang, Donna D

“…Oncogenic KRAS mutations found in 20% to 30% of all non-small cell lung cancers (NSCLC) are associated with chemoresistance and poor prognosis. Here we…”
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Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease by Stockwell, Brent R., Friedmann Angeli, José Pedro, Bayir, Hülya, Bush, Ashley I., Conrad, Marcus, Dixon, Scott J., Fulda, Simone, Gascón, Sergio, Hatzios, Stavroula K., Kagan, Valerian E., Noel, Kay, Jiang, Xuejun, Linkermann, Andreas, Murphy, Maureen E., Overholtzer, Michael, Oyagi, Atsushi, Pagnussat, Gabriela C., Park, Jason, Ran, Qitao, Rosenfeld, Craig S., Salnikow, Konstantin, Tang, Daolin, Torti, Frank M., Torti, Suzy V., Toyokuni, Shinya, Woerpel, K.A., Zhang, Donna D.

“…Ferroptosis is a form of regulated cell death characterized by the iron-dependent accumulation of lipid hydroperoxides to lethal levels. Emerging evidence…”
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Differential and overlapping targets of the transcriptional regulators NRF1, NRF2, and NRF3 in human cells by Liu, Pengfei, Kerins, Michael J., Tian, Wang, Neupane, Durga, Zhang, Donna D., Ooi, Aikseng

“…The nuclear factor (erythroid 2)-like (NRF) transcription factors are a subset of cap'n'collar transcriptional regulators. They consist of three members, NRF1,…”
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Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis by Wu, Tongde, Zhao, Fei, Gao, Beixue, Tan, Can, Yagishita, Naoko, Nakajima, Toshihiro, Wong, Pak K, Chapman, Eli, Fang, Deyu, Zhang, Donna D

“…Increased endoplasmic reticulum (ER) stress and reactive oxygen species (ROS) are the salient features of end-stage liver diseases. Using liver tissues from…”
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Arsenic Inhibits Autophagic Flux, Activating the Nrf2-Keap1 Pathway in a p62-Dependent Manner by Lau, Alexandria, Zheng, Yi, Tao, Shasha, Wang, Huihui, Whitman, Samantha A., White, Eileen, Zhang, Donna D.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Acetylation of Nrf2 by p300/CBP Augments Promoter-Specific DNA Binding of Nrf2 during the Antioxidant Response by Sun, Zheng, Chin, Y. Eugene, Zhang, Donna D.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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USP15 Negatively Regulates Nrf2 through Deubiquitination of Keap1 by Villeneuve, Nicole F., Tian, Wang, Wu, Tongde, Sun, Zheng, Lau, Alexandria, Chapman, Eli, Fang, Deyu, Zhang, Donna D.

“…Nrf2 is a master regulator of the antioxidant response. Under basal conditions, Nrf2 is polyubiquitinated by the Keap1-Cul3 E3 ligase and degraded by the 26S…”
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Kelch-like ECH-associated protein 1 (KEAP1) differentially regulates nuclear factor erythroid-2–related factors 1 and 2 (NRF1 and NRF2) by Tian, Wang, Rojo de la Vega, Montserrat, Schmidlin, Cody J., Ooi, Aikseng, Zhang, Donna D.

“…Nuclear factor erythroid-2–related factor 1 (NRF1) and NRF2 are essential for maintaining redox homeostasis and coordinating cellular stress responses. They…”
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Therapeutic potential of Nrf2 activators in streptozotocin-induced diabetic nephropathy by Zheng, Hongting, Whitman, Samantha A, Wu, Wei, Wondrak, Georg T, Wong, Pak K, Fang, Deyu, Zhang, Donna D

“…To determine whether dietary compounds targeting NFE2-related factor 2 (Nrf2) activation can be used to attenuate renal damage and preserve renal function…”
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Molecular mechanisms of Nrf2 regulation and how these influence chemical modulation for disease intervention by Harder, Bryan, Jiang, Tao, Wu, Tongde, Tao, Shasha, Rojo de la Vega, Montserrat, Tian, Wang, Chapman, Eli, Zhang, Donna D

“…Nrf2 (nuclear factor erytheroid-derived-2-like 2) transcriptional programmes are activated by a variety of cellular stress conditions to maintain cellular…”
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An Essential Role of NRF2 in Diabetic Wound Healing by Long, Min, Rojo de la Vega, Montserrat, Wen, Qing, Bharara, Manish, Jiang, Tao, Zhang, Rui, Zhou, Shiwen, Wong, Pak K, Wondrak, Georg T, Zheng, Hongting, Zhang, Donna D

“…The high mortality and disability of diabetic nonhealing skin ulcers create an urgent need for the development of more efficacious strategies targeting…”
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The Protective Role of Nrf2 in Streptozotocin-Induced Diabetic Nephropathy by TAO JIANG, ZHEPING HUANG, YIFENG LIN, ZHIGANG ZHANG, DEYU FANG, ZHANG, Donna D

“…Diabetic nephropathy is one of the major causes of renal failure, which is accompanied by the production of reactive oxygen species (ROS). Nrf2 is the primary…”
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