Lysine‐Based Ionic Liquid Enables Peptides to Reverse Skin Photoaging: From Leaves to Roots

Lysine‐Based Ionic Liquid Enables Peptides to Reverse Skin Photoaging: From Leaves to Roots

Peptides and proteins are pharmacologically active and highly safe; however, their local delivery remains a challenge in the field of drug delivery. Based on this, a novel lysine‐based ionic liquid via proton transfer between lysine and malic acid that can overcome the difficulties in the applicatio...

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Bibliographic Details
Published in:Advanced functional materials Vol. 33; no. 22
Main Authors: Liu, Tianqi, Zhang, Dilong, Pan, Zhihao, Yang, Huang, Ruan, Bo, Bo, Yiyang, Xie, Lin, Wang, Zhenyuan, Zhang, Jiaheng
Format: Journal Article
Language:English
Published: Hoboken Wiley Subscription Services, Inc 01-05-2023
Subjects:
Biocompatibility
Copper
Density functional theory
Dimensional analysis
extracellular matrix
ionic liquid microemulsion
Ionic liquids
Ions
Lysine
Malic acid
Materials science
Mathematical analysis
Microemulsions
Molecular docking
p53
Peptides
Sequences
skin photoaging
Vegetable oils
Viscosity
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Summary:Peptides and proteins are pharmacologically active and highly safe; however, their local delivery remains a challenge in the field of drug delivery. Based on this, a novel lysine‐based ionic liquid via proton transfer between lysine and malic acid that can overcome the difficulties in the application of copper peptides is developed. Density functional theory, molecular docking simulations, and experimental validation demonstrate the chemical stability of this ionic liquid. Furthermore, by combining it with a vegetable oil system, a biocompatible lysine‐based ionic liquid microemulsion system is constructed, which perfectly combines the high viscosity of ionic liquids and low viscosity of microemulsions. Multi‐dimensional analysis shows that the system not only leads to a dramatic elevation in the local penetration of copper peptides, but also enables copper peptides to effectively suppress skin aging. In addition, transcriptome sequencing analysis reveals that the system primarily regulates p53, p16, and ECM‐related signaling pathways to combat photoaging in the skin. Overall, a noninvasive, efficient, and convenient anti‐aging system with enormous potential is developed for the clinical prevention and treatment of skin photoaging. Starting from the application pain points of peptides, the respective characteristics of ionic liquids and microemulsions are combined to construct a delivery system with suitable viscosity and high efficiency for copper peptide targeting against skin aging. This work is not only informative for peptide applications, but also provides a reference for interdisciplinary cross‐sectional research.
ISSN:1616-301X
1616-3028
DOI:10.1002/adfm.202300723