Search Results - "Zhang, Daoguang"

Discovery of novel pyrazole derivatives as potential anticancer agents in MCL by Ran, Fansheng, Liu, Yang, Zhang, Daoguang, Liu, Meixia, Zhao, Guisen

“…[Display omitted] Mantle cell lymphoma (MCL) is characterized by the translocation t(11;14) (q13;q32), resulting in the overexpression of cyclin-D1. The…”
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Recent Developments in Androgen Receptor Antagonists by Ran, Fansheng, Xing, Hualu, Liu, Yang, Zhang, Daoguang, Li, Pengzhan, Zhao, Guisen

“…The androgen receptor (AR), a ligand‐dependent transcription factor that regulates the expression of a series of downstream target genes after the binding of…”
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Discovery of pyrazolopyrimidine derivatives as potent BTK inhibitors with effective anticancer activity in MCL by Ran, Fansheng, Liu, Yang, Liu, Meixia, Zhang, Daoguang, Wang, Peng, Dong, Junze, Tang, Wendi, Zhao, Guisen

“…[Display omitted] •Pyrazolopyrimidine derivatives as potent BTK inhibitors.•12a obtained antiproliferative effects in primary patient tumor cells.•12a showed…”
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Targeting Bruton's tyrosine kinase for the treatment of B cell associated malignancies and autoimmune diseases: Preclinical and clinical developments of small molecule inhibitors by Zhang, Zhen, Zhang, Daoguang, Liu, Yang, Yang, Dezhi, Ran, Fansheng, Wang, Michael L., Zhao, Guisen

“…B cell receptor (BCR) signaling plays a key role in B cell development and function. Aberrant BCR signaling has been confirmed as a central driver for the…”
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Structural optimization elaborates novel potent Akt inhibitors with promising anticancer activity by Liu, Yang, Yin, Yanzhen, Zhang, Zhen, Li, Carrie J., Zhang, Hui, Zhang, Daoguang, Jiang, Changying, Nomie, Krystle, Zhang, Liang, Wang, Michael L., Zhao, Guisen

“…Targeting of Akt has been validated as a well rationalized approach to cancer treatment, and represents a promising therapeutic strategy for aggressive…”
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Synthesis and biological evaluation of 3-(4-fluorophenyl)-1H-pyrazole derivatives as androgen receptor antagonists by Guo, Guangzhu, Liu, Jianzhen, Wang, Guanjie, Zhang, Daoguang, Lu, Jinjie, Zhao, Guisen

“…A novel series of 3-(4-fluorophenyl)-1H-pyrazole derivatives were synthesized and evaluated for their antiproliferative activity against two prostate cancer…”
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Discovery of novel 5‐methyl‐1 H ‐pyrazole derivatives as potential antiprostate cancer agents: Design, synthesis, molecular modeling, and biological evaluation by Zhang, Daoguang, Asnake, Solomon, Zhang, Jingya, Olsson, Per‐Erik, Zhao, Guisen

“…Androgen receptor ( AR ) signaling functions as a core driving force for the progression of prostate cancer ( PC a), and AR has been proved to be an effective…”
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Discovery of novel 5‐methyl‐1H‐pyrazole derivatives as potential antiprostate cancer agents: Design, synthesis, molecular modeling, and biological evaluation by Zhang, Daoguang, Asnake, Solomon, Zhang, Jingya, Olsson, Per‐Erik, Zhao, Guisen

“…Androgen receptor (AR) signaling functions as a core driving force for the progression of prostate cancer (PCa), and AR has been proved to be an effective…”
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Discovery of novel 5-methyl-1H-pyrazole derivatives as potential anti-prostate cancer agents: design, synthesis, molecular modeling and biological evaluation by Zhang, Daoguang, Asnake, Solomon, Zhang, Jingya, Olsson, Per-Erik, Zhao, Guisen

“…Androgen receptor (AR) signaling functions as a core driving force for the progression of prostate cancer (PCa), and AR has been proved to be an effective…”
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Design, synthesis and biological evaluation of AKT inhibitors bearing a piperidin-4-yl appendant by Zhang, Daoguang, Tong, Dongdong, Yang, Dezhi, Sun, Jing, Zhang, Fenghe, Zhao, Guisen

“…A series of AKT inhibitors possessing a piperidin-4-yl side chain was designed and synthesized. Some of them showed high AKT1 inhibitory activity and potent…”
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Design and discovery of 5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxamide inhibitors of HIV-1 integrase by Zhang, Daoguang, Debnath, Bikash, Yu, Shenghui, Sanchez, Tino Wilson, Christ, Frauke, Liu, Yang, Debyser, Zeger, Neamati, Nouri, Zhao, Guisen

“…Raltegravir (RAL) is a first clinically approved integrase (IN) inhibitor for the treatment of HIV but rapid mutation of the virus has led to chemo-resistant…”
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Design, synthesis, and biological evaluation of 2-(5-methyl-1H-pyrazol-1-yl) acetamide derivatives as androgen receptor antagonists by Dong, Junze, Zhang, Jingya, Li, Zilu, Asnake, Solomon, Zhang, Daoguang, Olsson, Per-Erik, Zhao, Guisen

“…Androgen receptor (AR) signaling is often activated in prostate cancer (PCa) cells, and blockage of this signaling by AR antagonists is an important strategy…”
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