Search Results - "Zhang, Chaoting"

Characterization of Microbiota in Cancerous Lung and the Contralateral Non-Cancerous Lung Within Lung Cancer Patients by Zhuo, Minglei, An, Tongtong, Zhang, Chaoting, Wang, Ziping

“…The functional role of lung microbiota has attracted an accumulating attention recently, but the profile and functional role of the lung microbiota in patients…”
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Membrane-bound IL-7 immobilized by the CD8 transmembrane region improves efficacy of CD19 CAR-T cell therapy by Zhang, Chaoting, Liu, Ting, Li, Shance, Teng, Xia, Zhu, Yuge, Zhang, Guanyu, Xie, Huimin, Sun, Kang, Tu, Jiaxin, Yang, Wenjun, Lu, Zheming

“…Enhancing the efficacy of CD19 CAR-T cell therapy can significantly improve patient outcomes by reducing relapse rates in CD19 + B cell malignancies. Exogenous…”
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CD19 CAR-T expressing PD-1/CD28 chimeric switch receptor as a salvage therapy for DLBCL patients treated with different CD19-directed CAR T-cell therapies by Liang, Yun, Liu, Hui, Lu, Zheming, Lei, Wen, Zhang, Chaoting, Li, Ping, Liang, Aibin, Young, Ken H, Qian, Wenbin

“…CD19-targeted chimeric antigen receptor T (CAR T) cell therapy is a promising option to treat relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL)…”
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Pre-depletion of TRBC1+ T cells promotes the therapeutic efficacy of anti-TRBC1 CAR-T for T-cell malignancies by Zhang, Chaoting, Palashati, Heyilimu, Rong, Zhuona, Lin, Ningjing, Shen, Luyan, Liu, Ying, Li, Shance, Yu, Bentong, Yang, Wenjun, Lu, Zheming

“…Abstract Targeting T cell receptor β-chain constant region 1 (TRBC1) CAR-T could specifically kill TRBC1+ T-cell malignancies. However, over-expressed CARs on…”
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Clonal Distribution and Intratumor Heterogeneity of the TCR Repertoire in Papillary Thyroid Cancer With or Without Coexistent Hashimoto’s Thyroiditis by Cui, Likun, Zhang, Chaoting, Ding, Huirong, Feng, Dongdong, Huang, Hongying, Lu, Zheming, Liu, Baoguo

“…The intratumor heterogeneity (ITH) of the amount and TCR repertoires of tumor infiltrating lymphocytes (TILs) in PTC with and without coexistent Hashimoto’s…”
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The direct and indirect association of cervical microbiota with the risk of cervical intraepithelial neoplasia by Zhang, Chaoting, Liu, Ying, Gao, Weijiao, Pan, Yaqi, Gao, Yunong, Shen, Jing, Xiong, Hongchao

“…Cervical microbiota composition is associated with cervical HPV infection and CIN severity. Previous studies only assessed the total association between…”
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T cell receptor β‐chain repertoire analysis of tumor‐infiltrating lymphocytes in pancreatic cancer by Cui, Can, Tian, Xiuyun, Wu, Jianhui, Zhang, Chaoting, Tan, Qin, Guan, Xiaoya, Dong, Bin, Zhao, Min, Lu, Zheming, Hao, Chunyi

“…Pancreatic cancer is lethal due to lack of perceptible symptoms and effective treatment methods. Immunotherapy may provide promising therapeutic choices for…”
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Pharmacologic inhibition of IL11/STAT3 signaling increases MHC-I expression and T cell infiltration by Xiong, Wenjun, Chen, Yuehong, Zhang, Chaoting, Li, Jin, Huang, Haipeng, Zhu, Yu, Deng, Guangxu, Cheng, Junhong, Lin, Yixiong, Shi, Zhimin, Mou, Tingyu

“…Recent studies have discovered an emerging role of IL11 in various colitis-associated cancers, suggesting that IL11 mainly promotes tumor cell survival and…”
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Isolation of T cell receptor specifically reactive with autologous tumour cells from tumour-infiltrating lymphocytes and construction of T cell receptor engineered T cells for esophageal squamous cell carcinoma by Tan, Qin, Zhang, Chaoting, Yang, Wenjun, Liu, Ying, Heyilimu, Palashati, Feng, Dongdong, Xing, Liying, Ke, Yang, Lu, Zheming

“…T cell receptor-engineered T cells (TCR-Ts) therapy is a promising cancer treatment strategy. Nowadays, most studies focused on identification of high-avidity…”
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Induction of EBV latent membrane protein-2A (LMP2A)-specific T cells and construction of individualized TCR-engineered T cells for EBV-associated malignancies by Zhang, Chaoting, Tan, Qin, Li, Shance, Shen, Luyan, Zhang, Jingtao, Liu, Ying, Yang, Wenjun, Lu, Zheming

“…BackgroundLatent membrane protein-2A (LMP2A)-specific TCR-engineered T cells could be a promising treatment approach to Epstein–Barr virus-associated…”
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Autophagic flux restoration enhances the antitumor efficacy of tumor infiltrating lymphocytes by Zhang, Chaoting, Sun, Yizhe, Li, Shance, Shen, Luyan, Teng, Xia, Xiao, Yefei, Wu, Nan, Lu, Zheming

“…BackgroundAlthough adoptive cell therapy with tumor infiltrating lymphocytes (TILs) has mediated effective antitumor responses in several cancers, dysfunction…”
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Seroprevalence of Merkel cell polyomavirus in the general rural population of Anyang, China by Zhang, Chanyuan, Liu, Fangfang, He, Zhonghu, Deng, Qiuju, Pan, Yaqi, Liu, Ying, Zhang, Chaoting, Ning, Tao, Guo, Chuanhai, Liang, Yongmei, Xu, Ruiping, Zhang, Lixin, Cai, Hong, Ke, Yang

“…Despite the probably causal link between Merkel cell polyomavirus (MCPyV) infection and Merkel cell carcinoma (MCC), a rare but aggressive skin malignancy,…”
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Epidemiology of self-rated health in rural China: a population-based cross-sectional study by Liu, Fangfang, Zhang, Chaoting, Liang, Yongmei, Deng, Qiuju, Hang, Dong, Pan, Yaqi, Li, Xiang, He, Zhonghu, Liu, Mengfei, Liu, Ying, Li, Jingjing, Ning, Tao, Guo, Chuanhai, Xu, Ruiping, Zhang, Lixin, Cai, Hong, Ke, Yang

“…Self-rated health (SRH) has been shown to be a good predictor of mortality. Data on SRH and its associated factors in the Chinese general population are…”
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Autophagic flux restoration of senescent T cells improves antitumor activity of TCR‐engineered T cells by Zhang, Chaoting, Sun, Yizhe, Li, Shance, Shen, Luyan, Teng, Xia, Xiao, Yefei, Zhou, Ping, Lu, Zheming

“…Objectives Although adoptive cell therapy with T‐cell receptor‐engineered T cells (TCR‐Ts) has mediated effective antitumor responses in several cancers,…”
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Oral microbiome and risk of malignant esophageal lesions in a high-risk area of China: A nested case-control study by Liu, Fangfang, Liu, Mengfei, Liu, Ying, Guo, Chuanhai, Zhou, Yunlai, Li, Fenglei, Xu, Ruiping, Liu, Zhen, Deng, Qiuju, Li, Xiang, Zhang, Chaoting, Pan, Yaqi, Ning, Tao, Dong, Xiao, Hu, Zhe, Bao, Huanyu, Cai, Hong, Silva, Isabel Dos Santos, He, Zhonghu, Ke, Yang

“…We aimed to prospectively evaluate the association of oral microbiome with malignant esophageal lesions and its predictive potential as a biomarker of risk. We…”
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Concurrence of oral and genital human papillomavirus infection in healthy men: a population-based cross-sectional study in rural China by Liu, Fangfang, Hang, Dong, Deng, Qiuju, Liu, Mengfei, Xi, Longfu, He, Zhonghu, Zhang, Chaoting, Sun, Min, Liu, Ying, Li, Jingjing, Pan, Yaqi, Ning, Tao, Guo, Chuanhai, Liang, Yongmei, Xu, Ruiping, Zhang, Lixin, Cai, Hong, Ke, Yang

“…Human papillomavirus (HPV) infection, a primary cause of genital cancer, is also related to the increasing incidence of oropharyngeal cancer among young men…”
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Differential DNA methylation profiles of human B lymphocytes and Epstein-Barr virus-immortalized B lymphocytes by Zhang, Chaoting, Zhang, Rui, Chen, Zhiqiang, Chen, Jing, Ruan, Jigang, Lu, Zheming, Xiong, Hongchao, Yang, Wenjun

“…This study aimed to comprehensively assess Epstein-Barr virus (EBV)-induced methylation alterations of B cell across whole genome. We compared DNA methylation…”
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CD19-specific CAR T Cells that Express a PD-1/CD28 Chimeric Switch-Receptor are Effective in Patients with PD-L1-positive B-Cell Lymphoma by Liu, Hui, Lei, Wen, Zhang, Chaoting, Yang, Chunmei, Wei, Juying, Guo, Qunyi, Guo, Xiaojun, Chen, Zhilu, Lu, Ying, Young, Ken H, Lu, Zheming, Qian, Wenbin

“…CD19-specific chimeric antigen receptor (CAR) T-cell therapy is effective against refractory or relapsed (R/R) B-cell lymphoma, but the efficacy is hindered by…”
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Metabolic reprogramming by ex vivo glutamine inhibition endows CAR-T cells with less-differentiated phenotype and persistent antitumor activity by Shen, Luyan, Xiao, Yefei, Zhang, Chaoting, Li, Shance, Teng, Xia, Cui, Likun, Liu, Ting, Wu, Nan, Lu, Zheming

“…The inadequate in vivo persistence of chimeric antigen receptor (CAR)-modified T cells has been shown to lead to poor therapeutic efficacy and disease…”
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TCR repertoire intratumor heterogeneity of CD4+ and CD8+ T cells in centers and margins of localized lung adenocarcinomas by Zhang, Chaoting, Ding, Huirong, Huang, Hongying, Palashati, Heyilimu, Miao, Yu, Xiong, Hongchao, Lu, Zheming

“…Intratumor heterogeneity (ITH) of T cell receptor (TCR) repertoire in different T‐cell subsets and locations in lung adenocarcinomas was unclear. Here, we…”
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