Search Results - "Zhan, Joyce"

Effects of the HIV‐1 maturation inhibitor GSK3640254 on QT interval in healthy participants by Zhang, Ying, Bush, Mark, Yazdani, Parto, Zhan, Joyce, Wen, Bo, Bainbridge, Veronica, Wynne, Brian R., Joshi, Samit, Lataillade, Max

“…GSK3640254 (GSK'254) is a novel HIV‐1 maturation inhibitor with pharmacokinetics supporting once‐daily (QD) therapy for HIV‐1 treatment. This thorough…”
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Phase I evaluation of the safety, tolerability, and pharmacokinetics of GSK3640254, a next‐generation HIV‐1 maturation inhibitor by Joshi, Samit R., Fernando, Disala, Igwe, Stephanie, McKenzie, Litza, Krishnatry, Anu S., Halliday, Fiona, Zhan, Joyce, Greene, Thomas J., Xu, Jianfeng, Ferron‐Brady, Geraldine, Lataillade, Max, Min, Sherene

“…Despite advances in HIV‐1 management with antiretroviral therapy, drug resistance and toxicities with multidrug regimens can result in treatment failure…”
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Open‐label, drug–drug interaction study between the HIV‐1 maturation inhibitor GSK3640254 and a metabolic probe cocktail in healthy participants by Zhang, Ying, Johnson, Mark, Joshi, Samit, Yazdani, Parto, Zhan, Joyce, Wen, Bo, Bainbridge, Veronica, Gartland, Martin, Lataillade, Max

“…Aims GSK3640254 (GSK'254) is an HIV‐1 maturation inhibitor with pharmacokinetics (PK) supporting once‐daily dosing. GSK'254 will be co‐administered with…”
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Investigation of Clinical Absorption, Distribution, Metabolism, and Excretion and Pharmacokinetics of the HIV-1 Maturation Inhibitor GSK3640254 Using an Intravenous Microtracer Combined with EnteroTracker for Biliary Sampling by Wen, Bo, Zhang, Ying, Young, Graeme C., Kenworthy, David, Pereira, Adrian, Pirhalla, Jill, Doyle, Janine, Jordon, Bethany, Zhan, Joyce, Johnson, Mark

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Pharmacokinetics and tolerability of the maturation inhibitor GSK3640254 coadministered with darunavir/ritonavir and/or etravirine in healthy adults by Zhang, Ying, Joshi, Samit, Yazdani, Parto, Zhan, Joyce, Wen, Bo, Bainbridge, Veronica, Ballesteros‐Perez, Alex, Gartland, Martin, Lataillade, Max

“…Aims This phase I study investigated potential drug–drug interactions of the maturation inhibitor GSK3640254 (GSK'254) with darunavir/ritonavir (DRV/RTV)…”
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A Phase I Evaluation of the Pharmacokinetics and Tolerability of the HIV-1 Maturation Inhibitor GSK3640254 and Tenofovir Alafenamide/Emtricitabine in Healthy Participants by Pene Dumitrescu, Teodora, Joshi, Samit R, Xu, Jianfeng, Zhan, Joyce, Johnson, Mark, Butcher, Laurie, Zimmerman, Eric, Webster, Lindsey, Davidson, Antonia M, Lataillade, Max, Min, Sherene

“…GSK3640254 is a next-generation maturation inhibitor that would likely be combined with standard antiretroviral agents to form a regimen of ≥2 fully active…”
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Phase IIa Proof-of-Concept Evaluation of the Antiviral Efficacy, Safety, Tolerability, and Pharmacokinetics of the Next-Generation Maturation Inhibitor GSK3640254 by Spinner, Christoph D, Felizarta, Franco, Rizzardini, Giuliano, Philibert, Patrick, Mitha, Essack, Domingo, Pere, Stephan, Christoph J, DeGrosky, Michelle, Bainbridge, Veronica, Zhan, Joyce, Dumitrescu, Teodora Pene, Jeffrey, Jerry L, Xu, Jianfeng, Halliday, Fiona, Gan, Jianjun, Johnson, Mark, Gartland, Martin, Joshi, Samit R, Lataillade, Max

“…GSK3640254 (GSK'254) is a next-generation human immunodeficiency virus type 1 (HIV-1) maturation inhibitor with pharmacokinetics (PK) supporting once-daily…”
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Relative Bioavailability and Food Effect of GSK3640254 Tablet and Capsule Formulations in Healthy Participants by Johnson, Mark, Pene Dumitrescu, Teodora, Joshi, Samit R., Mathew, Ashwin, Bainbridge, Veronica, Zhan, Joyce, Lataillade, Max

“…GSK3640254 is a next‐generation maturation inhibitor with demonstrated potency across HIV‐1 subtypes and a high barrier to emergent resistance. This phase I,…”
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