Search Results - "Zhan, Huiqing"
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High-Throughput Mapping of Long-Range Neuronal Projection Using In Situ Sequencing
Published in Cell (17-10-2019)“…Understanding neural circuits requires deciphering interactions among myriad cell types defined by spatial organization, connectivity, gene expression, and…”
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2
Integrating barcoded neuroanatomy with spatial transcriptional profiling enables identification of gene correlates of projections
Published in Nature neuroscience (01-06-2021)“…Functional circuits consist of neurons with diverse axonal projections and gene expression. Understanding the molecular signature of projections requires…”
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3
Massive multiplexing of spatially resolved single neuron projections with axonal BARseq
Published in Nature communications (27-09-2024)“…Neurons in the cortex are heterogeneous, sending diverse axonal projections to multiple brain regions. Unraveling the logic of these projections requires…”
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Inducible and repressable oncogene-addicted hepatocellular carcinoma in Tet-on xmrk transgenic zebrafish
Published in Journal of hepatology (01-02-2012)“…Background & Aims Liver cancer, mainly hepatocellular carcinoma, is a major malignancy and currently there are no effective treatment protocols due to…”
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5
SYNPLA, a method to identify synapses displaying plasticity after learning
Published in Proceedings of the National Academy of Sciences - PNAS (11-02-2020)“…Which neural circuits undergo synaptic changes when an animal learns? Although it is widely accepted that changes in synaptic strength underlie many forms of…”
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Sequencing the connectome
Published in PLoS biology (01-10-2012)“…Connectivity determines the function of neural circuits. Historically, circuit mapping has usually been viewed as a problem of microscopy, but no current…”
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A transgenic zebrafish liver tumor model with inducible Myc expression reveals conserved Myc signatures with mammalian liver tumors
Published in Disease models & mechanisms (01-03-2013)“…Myc is a pleiotropic transcription factor that is involved in many cellular activities relevant to carcinogenesis, including hepatocarcinogenesis. The…”
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Conservation of gene expression signatures between zebrafish and human liver tumors and tumor progression
Published in Nature biotechnology (01-01-2006)“…The zebrafish (Danio rerio) has been long advocated as a model for cancer research, but little is known about the real molecular similarities between zebrafish…”
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Comprehensive profiling of zebrafish hepatic proximal promoter CpG island methylation and its modification during chemical carcinogenesis
Published in BMC genomics (04-01-2011)“…DNA methylation is an epigenetic mechanism associated with regulation of gene expression and it is modulated during chemical carcinogenesis. The zebrafish is…”
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A ΔRaf1-ER-inducible oncogenic zebrafish liver cell model identifies hepatocellular carcinoma signatures
Published in The Journal of pathology (01-09-2011)“…Although the underlying molecular mechanism of hepatocellular carcinoma remains unclear, signalling pathways essential in cell survival and growth are altered,…”
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11
Ornamental Expression of Red Fluorescent Protein in Transgenic Founders of White Skirt Tetra (Gymnocorymbus ternetzi)
Published in Marine biotechnology (New York, N.Y.) (01-09-2008)“…Although the transgenic technology has been successfully used to generate fluorescent zebrafish and medaka for ornamental purposes, the practicability of the…”
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12
High-throughput sequencing of single neuron projections reveals spatial organization in the olfactory cortex
Published in Cell (27-10-2022)“…In most sensory modalities, neuronal connectivity reflects behaviorally relevant stimulus features, such as spatial location, orientation, and sound frequency…”
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13
Cellular anatomy of the mouse primary motor cortex
Published in Nature (London) (07-10-2021)“…An essential step toward understanding brain function is to establish a structural framework with cellular resolution on which multi-scale datasets spanning…”
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14
Single basolateral amygdala neurons in macaques exhibit distinct connectional motifs with frontal cortex
Published in Neuron (Cambridge, Mass.) (18-10-2023)“…Basolateral amygdala (BLA) projects widely across the macaque frontal cortex, and amygdalo-frontal projections are critical for appropriate emotional…”
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Axonal Barcode Analysis of Pyramidal Tract Projections from Mouse Forelimb M1 and M2
Published in The Journal of neuroscience (12-10-2022)“…Forelimb-related areas of the motor cortex communicate directly to downstream areas in the brainstem and spinal cord via axons that project to and through the…”
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Delayed and Restricted Expression of UAS-Regulated GFP Gene in Early Transgenic Zebrafish Embryos by Using the GAL4/UAS System
Published in Marine biotechnology (New York, N.Y.) (01-02-2010)“…A stable Tg(UAS:GFP) zebrafish line was generated and crossed with Tg(hsp70:GAL4) line, in which the GAL4 gene is under the control of an inducible zebrafish…”
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Modulation of the epigenome in fish carcinogenesis
Published in Toxicology letters (10-09-2014)Get full text
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18
A Delta DRaf1-ER-inducible oncogenic zebrafish liver cell model identifies hepatocellular carcinoma signatures
Published in The Journal of pathology (01-09-2011)“…Although the underlying molecular mechanism of hepatocellular carcinoma remains unclear, signalling pathways essential in cell survival and growth are altered,…”
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Transgenic Expression of Walleye Dermal Sarcoma Virus rv-cyclin Gene in Zebrafish and Its Suppressive Effect on Liver Tumor Development After Carcinogen Treatment
Published in Marine biotechnology (New York, N.Y.) (01-11-2010)“…A retrovirus homologue gene of cellular cyclin D ₁ , walleye dermal sarcoma virus rv-cyclin gene (orf A or rv-cyclin), was expressed in the livers of zebrafish…”
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Transgenic Expression of Walleye Dermal Sarcoma Virus rv-cyclin (orfA) in Zebrafish does not Result in Tissue Proliferation
Published in Marine biotechnology (New York, N.Y.) (01-04-2011)“…Walleye dermal sarcoma (WDS) is a benign tumor of walleye fish that develops and completely regresses seasonally. The retrovirus associated with this disease,…”
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