Search Results - "Zhai, Wenwu"

Precise determination of the diversity of a combinatorial antibody library gives insight into the human immunoglobulin repertoire by Glanville, Jacob, Zhai, Wenwu, Berka, Jan, Telman, Dilduz, Huerta, Gabriella, Mehta, Gautam R, Ni, Irene, Mei, Li, Sundar, Purnima D, Day, Giles M.R, Cox, David, Rajpal, Arvind, Pons, Jaume

“…Antibody repertoire diversity, potentially as high as 10¹¹ unique molecules in a single individual, confounds characterization by conventional sequence…”
Get full text

Anti–IL-7 receptor-α reverses established type 1 diabetes in nonobese diabetic mice by modulating effector T-cell function by Lee, Li-Fen, Logronio, Kathryn, Tu, Guang Huan, Zhai, Wenwu, Ni, Irene, Mei, Li, Dilley, Jeanette, Yu, Jessica, Rajpal, Arvind, Brown, Colleen, Appah, Charles, Chin, Sherman Michael, Han, Bora, Affolter, Timothy, Lin, John C

“…Genetic variation in the IL-7 receptor-α (IL-7R) gene is associated with susceptibility to human type 1 diabetes (T1D). Here we investigate the therapeutic…”
Get full text

A three monoclonal antibody combination potently neutralizes multiple botulinum neurotoxin serotype F subtypes by Fan, Yongfeng, Garcia-Rodriguez, Consuelo, Lou, Jianlong, Wen, Weihua, Conrad, Fraser, Zhai, Wenwu, Smith, Theresa J, Smith, Leonard A, Marks, James D

“…Human botulism is primarily caused by botulinum neurotoxin (BoNT) serotypes A, B and E, with around 1% caused by serotype F (BoNT/F). BoNT/F comprises at least…”
Get full text

Interleukin-6 involvement in brain arteriovenous malformations by Chen, Yongmei, Pawlikowska, Ludmila, Yao, Jianhua S., Shen, Fanxia, Zhai, Wenwu, Achrol, Achal S., Lawton, Michael T., Kwok, Pui-Yan, Yang, Guo-Yuan, Young, William L.

“…We recently reported that the GG genotype of the interleukin‐6 (IL‐6)–174G>C promoter polymorphism is associated with clinical presentation of intracranial…”
Get full text

Interleukin-6 triggers human cerebral endothelial cells proliferation and migration: The role for KDR and MMP-9 by Yao, Jianhua S., Zhai, Wenwu, Young, William L., Yang, Guo-Yuan

“…Interleukin-6 (IL-6) is involved in angiogenesis. However, the underlying mechanisms are unknown. Using human cerebral endothelial cell (HCEC), we report for…”
Get full text

Minocycline Exerts Multiple Inhibitory Effects on Vascular Endothelial Growth Factor–Induced Smooth Muscle Cell Migration: The Role of ERK1/2, PI3K, and Matrix Metalloproteinases by Yao, Jianhua S, Chen, Yongmei, Zhai, Wenwu, Xu, Kaiyan, Young, William L, Yang, Guo-Yuan

“…Widely used tetracycline antibiotics affect many cellular functions relevant to human vascular disease including cell proliferation, migration, and matrix…”
Get full text

Dose-response effect of tetracyclines on cerebral matrix metalloproteinase-9 after vascular endothelial growth factor hyperstimulation by Lee, Chanhung Z, Yao, Jianhua S, Huang, Yong, Zhai, Wenwu, Liu, Weizhong, Guglielmo, B Joseph, Lin, Emil, Yang, Guo-Yuan, Young, William L

“…Brain arteriovenous malformations (BAVMs) are a potentially life-threatening disorder. Matrix metalloproteinase (MMP)-9 activity was greatly increased in BAVM…”
Get full text

Interleukin-6 upregulates expression of KDR and stimulates proliferation of human cerebrovascular smooth muscle cells by Yao, Jianhua S, Zhai, Wenwu, Fan, Yongfeng, Lawton, Michael T, Barbaro, Nicholas M, Young, William L, Yang, Guo-Yuan

“…Interleukin-6 (IL-6) may play multiple roles in angiogenesis and vascular remodeling. Our previous study showed that a promoter polymorphism (174G>C) in IL-6…”
Get full text

Repeated Exposure to Ozone Increases Alveolar Macrophage Recruitment into Asthmatic Airways by Arjomandi, Mehrdad, Witten, Allyson, Abbritti, Emilio, Reintjes, Kurt, Schmidlin, Isabelle, Zhai, Wenwu, Solomon, Colin, Balmes, John

“…Repeated, short-term exposures to ozone (O3) lead to attenuation of the acute lung function and airway inflammatory responses seen after a single exposure in…”
Get full text

Suprabasal Desmoglein 3 Expression in the Epidermis of Transgenic Mice Results in Hyperproliferation and Abnormal Differentiation by Merritt, Anita J., Berika, Mohamed Y., Zhai, Wenwu, Kirk, Sarah E., Ji, Baijing, Hardman, Matthew J., Garrod, David R.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Mitogen‐activated protein kinase signalling pathways in IL‐1β‐dependent rat airway smooth muscle proliferation by Zhai, Wenwu, Eynott, Paul R, Oltmanns, Ute, Leung, Sum Yee, Chung, Kian Fan

“…Asthma is associated with abnormal airway smooth muscle (ASM) growth that may contribute to airway narrowing and hyperresponsiveness. We investigated the role…”
Get full text

Effects of Nitrogen Dioxide on Allergic Airway Responses in Subjects With Asthma by Witten, Allyson, Solomon, Colin, Abbritti, Emilio, Arjomandi, Mehrdad, Zhai, Wenwu, Kleinman, Michael, Balmes, John

“…Objective: We sought to determine whether nitrogen dioxide (NO₂) can enhance airway inflammation after allergen challenge in asthmatic subjects. Methods:…”
Get full text

TARGETING TREG CELLS BY TNFR2 ANTIBODY INDUCES TUMOR REGRESSION IN VIVO by Yi, Zuoan David, He, Chong, Hso, Yueh-Mei, Strainic, Michael, Yin, Yong, Zhai, Wenwu

“…Abstract Background Tumor necrosis factor receptor 2 (TNFR2) is considered an appealing target due to its low-level expression on immune cells, but it could be…”
Get full text

Precise and Efficient Antibody Epitope Determination through Library Design, Yeast Display and Next-Generation Sequencing by Van Blarcom, Thomas, Rossi, Andrea, Foletti, Davide, Sundar, Purnima, Pitts, Steven, Bee, Christine, Melton Witt, Jody, Melton, Zea, Hasa-Moreno, Adela, Shaughnessy, Lee, Telman, Dilduz, Zhao, Lora, Cheung, Wai Ling, Berka, Jan, Zhai, Wenwu, Strop, Pavel, Chaparro-Riggers, Javier, Shelton, David L., Pons, Jaume, Rajpal, Arvind

“…The ability of antibodies to bind an antigen with a high degree of affinity and specificity has led them to become the largest and fastest growing class of…”
Get full text

Synthetic Antibodies Designed on Natural Sequence Landscapes by Zhai, Wenwu, Glanville, Jacob, Fuhrmann, Markus, Mei, Li, Ni, Irene, Sundar, Purnima D., Van Blarcom, Thomas, Abdiche, Yasmina, Lindquist, Kevin, Strohner, Ralf, Telman, Dilduz, Cappuccilli, Guido, Finlay, William J.J., Van den Brulle, Jan, Cox, David R., Pons, Jaume, Rajpal, Arvind

“…We present a method for synthetic antibody library generation that combines the use of high-throughput immune repertoire analysis and a novel synthetic…”
Get full text

Productive common light chain libraries yield diverse panels of high affinity bispecific antibodies by Van Blarcom, Thomas, Lindquist, Kevin, Melton, Zea, Cheung, Wai Ling, Wagstrom, Chris, McDonough, Dan, Valle Oseguera, Cendy, Ding, Sheng, Rossi, Andrea, Potluri, Shobha, Sundar, Purnima, Pitts, Steven, Sirota, Marina, Galindo Casas, Meri, Yan, Yu, Jones, Jeffrey, Roe-Zurz, Zygy, Srivatsa Srinivasan, Surabhi, Zhai, Wenwu, Pons, Jaume, Rajpal, Arvind, Chaparro-Riggers, Javier

“…The commercial success of bispecific antibodies generally has been hindered by the complexities associated with generating appropriate molecules for both…”
Get full text

Hypervariable region diversity of hepatitis C virus and humoral response: Comparison between patients with or without cirrhosis by Allain, Jean-Pierre, Zhai, Wenwu, Shang, Dazhuang, Timmers, Erik, Alexander, Graeme JM

“…To investigate the potential clinical utility of antibody response to HVR1 of HCV, the genomic and amino acid diversity of HVR1 was compared between two groups…”
Get full text

Blockade of CD127 Exerts a Dichotomous Clinical Effect in Marmoset Experimental Autoimmune Encephalomyelitis by Dunham, Jordon, Lee, Li-Fen, van Driel, Nikki, Laman, Jon D., Ni, Irene, Zhai, Wenwu, Tu, Guang-Huan, Lin, John C., Bauer, Jan, ‘t Hart, Bert A., Kap, Yolanda S.

“…Non-human primate models of human disease have an important role in the translation of a new scientific finding in lower species into an effective treatment…”
Get full text

Correction: Anti-IL-7 receptor-α reverses established type 1 diabetes in nonobese diabetic mice by modulating effector T-cell function by Lee, Li-Fen, Logronio, Kathryn, Tu, Guang Huan, Zhai, Wenwu, Ni, Irene, Mei, Li, Dilley, Jeanette, Yu, Jessica, Rajpal, Arvind, Brown, Colleen, Appah, Charles, Chin, Sherman Michael, Han, Bora, Affolter, Timothy, Lin, John C.

Get full text

Anti-IL-7 receptor-[alpha] reverses established type 1 diabetes in nonobese diabetic mice by modulating effector T-cell function by Lee, Li-Fen, Logronio, Kathryn, Tu, Guang Huan, Zhai, Wenwu, Ni, Irene, Mei, Li, Dilley, Jeanette, Yu, Jessica, Rajpal, Arvind, Brown, Colleen, Appah, Charles, Chin, Sherman Michael, Han, Bora, Affolter, Timothy, Lin, John C

“…Genetic variation in the IL-7 receptor-... (IL-7R) gene is associated with susceptibility to human type 1 diabetes (T1D). Here we investigate the therapeutic…”
Get full text