Search Results - "Zhai, Qiaocheng"

Impaired function of the suprachiasmatic nucleus rescues the loss of body temperature homeostasis caused by time-restricted feeding by Zhang, Zhihui, Zhai, Qiaocheng, Gu, Yue, Zhang, Tao, Huang, Zhengyun, Liu, Zhiwei, Liu, Yi, Xu, Ying

“…The suprachiasmatic nucleus (SCN) is the master circadian pacemaker that drives body temperature rhythm. Time-restricted feeding (TRF) has potential as a…”
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Nuclear receptor modulators inhibit osteosarcoma cell proliferation and tumour growth by regulating the mTOR signaling pathway by Yuan, Baoshi, Shi, Kexin, Zha, Juanmin, Cai, Yujia, Gu, Yue, Huang, Kai, Yue, Wenchang, Zhai, Qiaocheng, Ding, Ning, Ren, Wenyan, He, Weiqi, Xu, Ying, Wang, Tao

“…Osteosarcoma is the most common primary malignant bone tumour in children and adolescents. Chemoresistance leads to poor responses to conventional therapy in…”
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Long-term SCN calcium signal recording in freely moving mice by Zhai, Qiaocheng, Zeng, Yizhun, Li, Zhihao, Xu, Youjia, Xu, Ying

“…The suprachiasmatic nucleus (SCN) is the master circadian pacemaker of the mammalian biological clock. Here, we provide a detailed protocol for long-term…”
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A critical signal for phenotype transition driven by negative feedback loops by Wang, Yao, Dong, Yingying, Zhai, Qiaocheng, Zhang, Wei, Xu, Ying, Yang, Ling

“…The biological rhythms governed by negative feedback loops have undergone extensive investigation. However, developing reliable and versatile warning signals…”
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Light-phase time-restricted feeding disrupts the muscle clock and insulin sensitivity yet potentially induces muscle fiber remodeling in mice by Ye, Zhou, Huang, Kai, Dai, Xueqin, Gao, Dandan, Gu, Yue, Qian, Jun, Zhang, Feng, Zhai, Qiaocheng

“…Skeletal muscle plays a critical role in regulating systemic metabolic homeostasis. It has been demonstrated that time-restricted feeding (TRF) during the rest…”
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IMPC-based screening revealed that ROBO1 can regulate osteoporosis by inhibiting osteogenic differentiation by Zhang, Xiangzheng, Wang, Yike, Zheng, Miao, Wei, Qi, Zhang, Ruizhi, Zhu, Keyu, Zhai, Qiaocheng, Xu, Youjia

“…The utilization of denosumab in treating osteoporosis highlights promising prospects for osteoporosis intervention guided by gene targets. While omics-based…”
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High-throughput discovery of genetic determinants of circadian misalignment by Zhang, Tao, Xie, Pancheng, Dong, Yingying, Liu, Zhiwei, Zhou, Fei, Pan, Dejing, Huang, Zhengyun, Zhai, Qiaocheng, Gu, Yue, Wu, Qingyu, Tanaka, Nobuhiko, Obata, Yuichi, Bradley, Allan, Lelliott, Christopher J, Nutter, Lauryl M J, McKerlie, Colin, Flenniken, Ann M, Champy, Marie-France, Sorg, Tania, Herault, Yann, Angelis, Martin Hrabe De, Durner, Valerie Gailus, Mallon, Ann-Marie, Brown, Steve D M, Meehan, Terry, Parkinson, Helen E, Smedley, Damian, Lloyd, K C Kent, Yan, Jun, Gao, Xiang, Seong, Je Kyung, Wang, Chi-Kuang Leo, Sedlacek, Radislav, Liu, Yi, Rozman, Jan, Yang, Ling, Xu, Ying

“…Circadian systems provide a fitness advantage to organisms by allowing them to adapt to daily changes of environmental cues, such as light/dark cycles. The…”
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Time-restricted feeding entrains long-term behavioral changes through the IGF2-KCC2 pathway by Zhai, Qiaocheng, Zeng, Yizhun, Gu, Yue, Li, Zhihao, Zhang, Tao, Yuan, Baoshi, Wang, Tao, Yan, Jie, Qin, Han, Yang, Ling, Chen, Xiaowei, Vidal-Puig, Antonio, Xu, Ying

“…The suprachiasmatic nucleus (SCN) integrates light and systemic signals from peripheral tissues to coordinate physiology and behavior daily rhythms. However,…”
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Osteoporotic bone loss from excess iron accumulation is driven by NOX4-triggered ferroptosis in osteoblasts by Zhang, Hui, Wang, Aifei, Li, Guangfei, Zhai, Qiaocheng, Huang, Zhengyun, Wang, Xiao, Cao, Zihou, Liu, Lulin, Liu, Gongwen, Chen, Bin, Zhu, Keyu, Xu, Ying, Xu, Youjia

“…Excess iron accumulation is a risk factor for osteopenia and osteoporosis, and ferroptosis is becoming well understood as iron-dependent form of cell death…”
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Repression of YEATS2 induces cellular senescence in hepatocellular carcinoma and inhibits tumor growth by Wu, Qi, Zheng, Quan, Yuan, Lei, Gao, Dandan, Hu, Yabing, Jiang, Xinqing, Zhai, Qiaocheng, Liu, Ming, Xu, Lifeng, Xu, Heng, Ye, Jinlin, Zhang, Feng

“…Hepatocellular carcinoma (HCC) stands as the third leading cause of cancer-related fatalities globally. In this study, we observed a significant increase in…”
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Multitissue Circadian Proteome Atlas of WT and Per1 -/- /Per2 -/- Mice by Qian, Liujia, Gu, Yue, Zhai, Qiaocheng, Xue, Zhangzhi, Liu, Youqi, Li, Sainan, Zeng, Yizhun, Sun, Rui, Zhang, Qiushi, Cai, Xue, Ge, Weigang, Dong, Zhen, Gao, Huanhuan, Zhou, Yan, Zhu, Yi, Xu, Ying, Guo, Tiannan

“…The molecular basis of circadian rhythm, driven by core clock genes such as Per1/2, has been investigated on the transcriptome level, but not comprehensively…”
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HALL: a comprehensive database for human aging and longevity studies by Li, Hao, Wu, Song, Li, Jiaming, Xiong, Zhuang, Yang, Kuan, Ye, Weidong, Ren, Jie, Wang, Qiaoran, Xiong, Muzhao, Zheng, Zikai, Zhang, Shuo, Han, Zichu, Yang, Peng, Jiang, Beier, Ping, Jiale, Zuo, Yuesheng, Lu, Xiaoyong, Zhai, Qiaocheng, Yan, Haoteng, Wang, Si, Ma, Shuai, Zhang, Bing, Ye, Jinlin, Qu, Jing, Yang, Yun-Gui, Zhang, Feng, Liu, Guang-Hui, Bao, Yiming, Zhang, Weiqi

“…Abstract Diverse individuals age at different rates and display variable susceptibilities to tissue aging, functional decline and aging-related diseases…”
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Aging induces region-specific dysregulation of hormone synthesis in the primate adrenal gland by Wang, Qiaoran, Wang, Xuebao, Liu, Beibei, Ma, Shuai, Zhang, Feng, Sun, Shuhui, Jing, Yaobin, Fan, Yanling, Ding, Yingjie, Xiong, Muzhao, Li, Jiaming, Zhai, Qiaocheng, Zheng, Yandong, Liu, Chengyu, Xu, Gang, Yang, Jiayin, Wang, Si, Ye, Jinlin, Izpisua Belmonte, Juan Carlos, Qu, Jing, Liu, Guang-Hui, Zhang, Weiqi

“…Adrenal glands, vital for steroid secretion and the regulation of metabolism, stress responses and immune activation, experience age-related decline, impacting…”
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