Search Results - "Zhai, Jinghui"

Dysregulation of BSEP and MRP2 May Play an Important Role in Isoniazid-Induced Liver Injury via the SIRT1/FXR Pathway in Rats and HepG2 Cells by Qu, Xiaoyu, Zhang, Yueming, Zhang, Sixi, Zhai, Jinghui, Gao, Huan, Tao, Lina, Song, Yanqing

“…To explore the role of the abnormal expression of the bile salt export pump (BSEP) and multidrug resistance protein 2 (MRP2) in isoniazid (INH)-induced liver…”
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Astragaloside IV protects against cisplatin-induced liver and kidney injury via autophagy-mediated inhibition of NLRP3 in rats by Qu, Xiaoyu, Gao, Huan, Tao, Lina, Zhang, Yueming, Zhai, Jinghui, Sun, Jingmeng, Song, Yanqing, Zhang, Sixi

“…The aim of this study was to explore the role of the NOD-like receptor family, pyrin domain containing (NLRP3) inflammasome and autophagy in Astragaloside IV…”
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Calycosin ameliorates doxorubicin‐induced cardiotoxicity by suppressing oxidative stress and inflammation via the sirtuin 1–NOD‐like receptor protein 3 pathway by Zhai, Jinghui, Tao, Lina, Zhang, Sixi, Gao, Huan, Zhang, Yueming, Sun, Jingmeng, Song, Yanqing, Qu, Xiaoyu

“…The limitation of doxorubicin (DOX), which is widely used for the treatment of solid tumors and hematologic malignancies, is a vital problem in clinical…”
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Identification of key metabolites during cisplatin-induced acute kidney injury using an HPLC-TOF/MS-based non-targeted urine and kidney metabolomics approach in rats by Qu, Xiaoyu, Gao, Huan, Sun, Jingmeng, Tao, Lina, Zhang, Yueming, Zhai, Jinghui, Song, Yanqing, Hu, Tingting, Li, Zhiyuan

“…•37 and 35 metabolite levels changed in rat urine and kidneys by CDDP-induced AKI.•7 key metabolic pathways were significantly disrupted by CDDP-induced…”
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Potential role of irisin in digestive system diseases by Zhang, Yueming, Zhao, Linxian, Gao, Huan, Zhai, Jinghui, Song, Yanqing

“…Digestive system diseases (DSD) are very complex conditions that severely threaten human health. Therefore, there is an urgent need to develop new…”
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Quercetin attenuates NLRP3 inflammasome activation and apoptosis to protect INH-induced liver injury via regulating SIRT1 pathway by Zhang, Yueming, Qu, Xiaoyu, Gao, Huan, Zhai, Jinghui, Tao, Lina, Sun, Jingmeng, Song, Yanqing, Zhang, Jie

“…•Quercetin inhibited INH-induced liver injury.•Quercetin regulated NLRP3 inflammasome via SIRT1 in INH-induced hepatotoxicity.•SIRT1 participatedin the…”
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Involvement of the SIRT1-NLRP3 pathway in the inflammatory response by Chen, Huiyue, Deng, Jiayu, Gao, Huan, Song, Yanqing, Zhang, Yueming, Sun, Jingmeng, Zhai, Jinghui

“…The silent information regulator 2 homolog 1-NACHT, LRR and PYD domains-containing protein 3 (SIRT1-NLRP3) pathway has a crucial role in regulation of the…”
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The SIRT1-HMGB1 axis: Therapeutic potential to ameliorate inflammatory responses and tumor occurrence by Wei, Lanyi, Zhang, Wenrui, Li, Yueyang, Zhai, Jinghui

“…Inflammation is a common complication of many chronic diseases. It includes inflammation of the parenchyma and vascular systems. Sirtuin 1 (SIRT1) is a…”
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Egg white protein hydrolysate ameliorated sepsis-induced inflammatory injuries in kidney and liver based on metabolomics analysis by Huan, Gao, Tao, Yang, Yu, Wang, Jinghui, Zhai, Yueming, Zhang, Yanqing, Song

“…Sepsis caused by infection could induce systemic inflammation and various organ damages. Bioactivities of peptides derived from eggs were proved by lots of…”
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Omeprazole protects against cisplatin-induced nephrotoxicity by alleviating oxidative stress, inflammation, and transporter-mediated cisplatin accumulation in rats and HK-2 cells by Gao, Huan, Zhang, Sixi, Hu, Tingting, Qu, Xiaoyu, Zhai, Jinghui, Zhang, Yueming, Tao, Lina, Yin, Jianyuan, Song, Yanqing

“…The present study assessed the therapeutic potential of omeprazole (OME), the most commonly prescribed proton pump inhibitor (PPI) used to treat…”
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Floor Failure Evolution Mechanism for a Fully Mechanized Longwall Mining Face above a Confined Aquifer by Wang, Fangtian, Li, Gang, Liu, Danlong, Zhai, Jinghui

“…In longwall mining, the risk of water inrushes from the floors of deeply buried coal seams is closely related to the degree and depth of the destruction for…”
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Huaiqihuang (HQH) granule alleviates cyclophosphamide-induced nephrotoxicity via suppressing the MAPK/NF-κB pathway and NLRP3 inflammasome activation by Zhang, Yueming, Chang, Jian, Gao, Huan, Qu, Xiaoyu, Zhai, Jinghui, Tao, Lina, Sun, Jingmeng, Song, Yanqing

“…Severe nephrotoxicity greatly limits the clinical use of the common effective chemotherapeutic agent cyclophosphamide (CYP). Huaiqihuang (HQH) is a Chinese…”
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Antioxidant Effect of Tyr-Ala Extracted from Zein on INS-1 Cells and Type 2 Diabetes High-Fat-Diet-Induced Mice by Zhai, Jinghui, Zhu, Yuhua, Wu, Yi, Li, Na, Cao, Yue, Guo, Yi, Xu, Li

“…Type 2 diabetes mellitus (T2DM) is associated with an oxidative milieu that often leads to adverse health problems. Bioactive peptides of zein possess…”
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Omeprazole attenuates cisplatin-induced kidney injury through suppression of the TLR4/NF-κB/NLRP3 signaling pathway by Gao, Huan, Wang, Xiangfeng, Qu, Xiaoyu, Zhai, Jinghui, Tao, Lina, Zhang, Yueming, Song, Yanqing, Zhang, Wenrui

“…•OME protects against cisplatin-induced nephrotoxicity in rats and HK-2 cells.•OME exerts renoprotective effects by suppressing inflammatory response.•OME…”
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Astragaloside IV enhances cisplatin chemosensitivity in hepatocellular carcinoma by suppressing MRP2 by Qu, Xiaoyu, Gao, Huan, Zhai, Jinghui, Sun, Jingmeng, Tao, Lina, Zhang, Yueming, Song, Yanqing, Hu, Tingting

“…•AS IV could enhance the chemosensitivity of cisplatin in HepG2 cells.•AS IV could enhance anti-tumor effect of cisplatin in H22 tumor-bearing mice.•AS IV may…”
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Altered metabolic profiles and biomarkers associated with astragaloside IV-mediated protection against cisplatin-induced acute kidney injury in rats: An HPLC-TOF/MS-based untargeted metabolomics study by Song, Yanqing, Hu, Tingting, Gao, Huan, Zhai, Jinghui, Gong, Jiawei, Zhang, Yueming, Tao, Lina, Sun, Jingmeng, Li, Zhiyuan, Qu, Xiaoyu

“…[Display omitted] Cisplatin (CDDP)-induced acute kidney injury (AKI) limits the therapeutic use of CDDP, which urgently needs to be addressed. Our previous…”
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Polypharmacy and potentially inappropriate medications among elderly patients in the geriatric department at a single-center in China: A retrospective cross-sectional study by Tao, Lina, Qu, Xiaoyu, Gao, Huan, Zhai, Jinghui, Zhang, Yueming, Song, Yanqing

“…The aging of the population has become a worldwide concern, especially in China. Polypharmacy and potentially inappropriate medications (PIMs) are prominent…”
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The identification of key metabolites and mechanisms during isoniazid/rifampicin-induced neurotoxicity and hepatotoxicity in a mouse model by HPLC-TOF/MS-based untargeted urine metabolomics by Song, Yanqing, Ma, Jie, Gao, Huan, Zhai, Jinghui, Zhang, Yueming, Gong, Jiawei, Qu, Xiaoyu, Hu, Tingting

“…The co-administration of isoniazid (INH) and rifampicin (RIF) is associated with hepatotoxicity and neurotoxicity. To systematically investigate the mechanisms…”
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Integration of metabolomics and proteomics analysis to explore the mechanism of neurotoxicity induced by receipt of isoniazid and rifampicin in mice by Qu, Xiaoyu, Ma, Jie, Gao, Huan, Zhang, Yueming, Zhai, Jinghui, Gong, Jiawei, Song, Yanqing, Hu, Tingting

“…Isoniazid (INH) and rifampicin (RIF) are co-administered in tuberculosis treatment but can cause neurotoxicity, and the mechanism is not known. To explore this…”
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Untargeted metabolomics analysis of omeprazole-enhanced chemosensitivity to cisplatin in mice with non-small cell lung cancer by Gao, Huan, Song, Yanqing, Ma, Jie, Zhai, Jinghui, Zhang, Yueming, Qu, Xiaoyu

“…Drug resistance of tumors remains a major barrier in cisplatin (CDDP)-based chemotherapy. Omeprazole (OME) is often utilized during chemotherapy to alleviate…”
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