Atrial natriuratic peptide and experimental vasorenal hypertension in rats

Vasorenal hypertension in rats resulted in increase of arterial pressure, the plasma concentration of creatinine and potassium. By EM immunocytochemistry we have demonstrated that atrial natriuretic peptide (ANP) was kept in the granules of secretory cardiomyocytes of the right atrium. It has shown...

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Bibliographic Details
Published in:	Patologicheskaia fiziologiia i eksperimental'naia terapiia no. 4; p. 31
Main Authors:	Rakhcheeva, M V, Bugrova, M L, Mukhina, I V, Zhabereva, A S
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-10-2010
Subjects:	Animals Atrial Natriuretic Factor - blood Blood Pressure Hypertension - blood Hypertension - pathology Hypertension - physiopathology Myocytes, Cardiac - metabolism Myocytes, Cardiac - ultrastructure Rats Receptors, Atrial Natriuretic Factor - metabolism Secretory Vesicles - metabolism Secretory Vesicles - ultrastructure
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Summary:	Vasorenal hypertension in rats resulted in increase of arterial pressure, the plasma concentration of creatinine and potassium. By EM immunocytochemistry we have demonstrated that atrial natriuretic peptide (ANP) was kept in the granules of secretory cardiomyocytes of the right atrium. It has shown that cardiomyocytes released ANP by means of diffusion. The increased secretion of atrial natriuretic peptide has been detected in blood. However the physiological effects this peptide probably was impaired due to the reducing of the density of natriuretic peptide receptors.
ISSN:	0031-2991