Search Results - "Zha, Xiang‐ming"

RNA‐Seq analysis of knocking out the neuroprotective proton‐sensitive GPR68 on basal and acute ischemia‐induced transcriptome changes and signaling in mouse brain by Zhou, Guokun, Wang, Tao, Zha, Xiang‐ming

“…Brain acid signaling plays important roles in both physiological and disease conditions. One key neuronal metabotropic proton receptor in the brain is GPR68,…”
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Acid-sensing ion channels: trafficking and synaptic function by Zha, Xiang-ming

“…Extracellular acidification occurs in the brain with elevated neural activity, increased metabolism, and neuronal injury. This reduction in pH can have…”
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Protons are a neurotransmitter that regulates synaptic plasticity in the lateral amygdala by Du, Jianyang, Reznikov, Leah R., Price, Margaret P., Zha, Xiang-ming, Lu, Yuan, Moninger, Thomas O., Wemmie, John A., Welsh, Michael J.

“…Stimulating presynaptic terminals can increase the proton concentration in synapses. Potential receptors for protons are acid-sensing ion channels (ASICs), Na…”
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Infection‐induced endothelial amyloids impair memory by Balczon, Ron, Pittet, Jean‐Francois, Wagener, Brant M., Moser, Stephen A., Voth, Sarah, Vorhees, Charles V., Williams, Michael T., Bridges, James P., Alvarez, Diego F., Koloteva, Anna, Xu, Yuanyuan, Zha, Xiang‐Ming, Audia, Jonathon P., Stevens, Troy, Lin, Mike T.

“…ABSTRACTPatients with nosocomial pneumonia exhibit elevated levels of neurotoxic amyloid and tau proteins in the cerebrospinal fluid (CSF). In vitro studies…”
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GPR68 deletion impairs hippocampal long-term potentiation and passive avoidance behavior by Xu, Yuanyuan, Lin, Mike T, Zha, Xiang-Ming

“…Increased neural activities reduced pH at the synaptic cleft and interstitial spaces. Recent studies have shown that protons function as a neurotransmitter…”
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GPR68 limits the severity of chemical-induced oral epithelial dysplasia by Shore, David, Griggs, Nosakhere, Graffeo, Vincent, Amin, A. R. M. Ruhul, Zha, Xiang-ming, Xu, Yan, McAleer, Jeremy P.

“…Head and neck cancer is the sixth most common malignancy, and there is an urgent need to identify physiological processes contributing to tumorigenesis…”
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Immunoaffinity profiling of tyrosine phosphorylation in cancer cells by Comb, Michael J, Rush, John, Moritz, Albrecht, Lee, Kimberly A, Guo, Ailan, Goss, Valerie L, Spek, Erik J, Zhang, Hui, Zha, Xiang-Ming, Polakiewicz, Roberto D

“…Tyrosine kinases play a prominent role in human cancer, yet the oncogenic signaling pathways driving cell proliferation and survival have been difficult to…”
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Acid-Sensing Ion Channels Contribute to Type III Adenylyl Cyclase–Independent Acid Sensing of Mouse Olfactory Sensory Neurons by Yang, Juan, Qiu, Liyan, Strobel, Matthew, Kabel, Amanda, Zha, Xiang-Ming, Chen, Xuanmao

“…Acids can disturb the ecosystem of wild animals through altering their olfaction and olfaction-related survival behaviors. It is known that the main olfactory…”
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ASIC subunit ratio and differential surface trafficking in the brain by Wu, Junjun, Xu, Yuanyuan, Jiang, Yu-Qing, Xu, Jiangping, Hu, Youjia, Zha, Xiang-ming

“…Acid-sensing ion channels (ASICs) are key mediators of acidosis-induced responses in neurons. However, little is known about the relative abundance of…”
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Time-dependent progression of hemorrhagic transformation after transient ischemia and its association with GPR68-dependent protection by Wang, Tao, He, Mindi, Zha, Xiang-ming

“…Hemorrhagic transformation (HT) following ischemia is one complication which worsens stroke outcome. During and after ischemia–reperfusion, persistent…”
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N-glycosylation of acid-sensing ion channel 1a regulates its trafficking and acidosis-induced spine remodeling by Jing, Lan, Chu, Xiang-Ping, Jiang, Yu-Qing, Collier, Daniel M, Wang, Bin, Jiang, Qian, Snyder, Peter M, Zha, Xiang-Ming

“…Acid-sensing ion channel-1a (ASIC1a) is a potential therapeutic target for multiple neurological diseases. We studied here ASIC1a glycosylation and…”
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Targeting ASIC1a Reduces Innate Fear and Alters Neuronal Activity in the Fear Circuit by Coryell, Matthew W, Ziemann, Adam E, Westmoreland, Patricia J, Haenfler, Jill M, Kurjakovic, Zlatan, Zha, Xiang-ming, Price, Margaret, Schnizler, Mikael K, Wemmie, John A

“…Background The molecular mechanisms underlying innate fear are poorly understood. Previous studies indicated that the acid sensing ion channel ASIC1a…”
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Histidine Residues Are Responsible for Bidirectional Effects of Zinc on Acid-Sensing Ion Channel 1a/3 Heteromeric Channels by Jiang, Qian, Peterson, Andrew M, Chu, Yuyang, Yao, Xiaolan, Zha, Xiang-Ming, Chu, Xiang-Ping

“…Acid-sensing ion channel (ASIC) subunits 1a and 3 are highly expressed in central and peripheral sensory neurons, respectively. Endogenous biomolecule zinc…”
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Oxidant regulated inter-subunit disulfide bond formation between ASIC1a subunits by Zha, Xiang-ming, Wang, Runping, Collier, Dan M, Snyder, Peter M, Wemmie, John A, Welsh, Michael J

“…The acid-sensing ion channel-1a (ASIC1a) is composed of 3 subunits and is activated by a decrease in extracellular pH. It plays an important role in diseases…”
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Two di-leucine motifs regulate trafficking and function of mouse ASIC2a by Wu, Junjun, Leng, Tiandong, Jing, Lan, Jiang, Nan, Chen, Daijie, Hu, Youjia, Xiong, Zhi-Gang, Zha, Xiang-ming

“…Acid-sensing ion channels (ASICs) are proton-gated cation channels that mediate acid-induced responses in neurons. ASICs are important for mechanosensation,…”
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A Kinase Anchor Protein 150 (AKAP150)-associated Protein Kinase A Limits Dendritic Spine Density by Lu, Yuan, Zha, Xiang-ming, Kim, Eun Young, Schachtele, Scott, Dailey, Michael E., Hall, Duane D., Strack, Stefan, Green, Steven H., Hoffman, Dax A., Hell, Johannes W.

“…The A kinase anchor protein AKAP150 recruits the cAMP-dependent protein kinase (PKA) to dendritic spines. Here we show that in AKAP150 (AKAP5) knock-out (KO)…”
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The interaction between the first transmembrane domain and the thumb of ASIC1a is critical for its N-glycosylation and trafficking by Jing, Lan, Jiang, Yu-Qing, Jiang, Qian, Wang, Bin, Chu, Xiang-Ping, Zha, Xiang-Ming

“…Acid-sensing ion channel-1a (ASIC1a), the primary proton receptor in the brain, contributes to multiple diseases including stroke, epilepsy and multiple…”
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PICK1 regulates the trafficking of ASIC1a and acidotoxicity in a BAR domain lipid binding-dependent manner by Jin, Wenying, Shen, Chong, Jing, Lan, Zha, Xiang-ming, Xia, Jun

“…Acid-sensing ion channel 1a (ASIC1a) is the major ASIC subunit determining acid-activated currents in brain neurons. Recent studies show that ASIC1a play…”
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pH and proton-sensitive receptors in brain ischemia by Zha, Xiang-ming, Xiong, Zhi-Gang, Simon, Roger P

“…Extracellular proton concentration is at 40 nM when pH is 7.4. In disease conditions such as brain ischemia, proton concentration can reach µM range. To…”
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Role of Ca2+/calmodulin-dependent protein kinase II in dendritic spine remodeling during epileptiform activity in vitro by Zha, Xiang-ming, Dailey, Michael E., Green, Steven H.

“…Epileptiform activity (EA) in vivo and in vitro induces a loss of dendritic spines and synapses. Because CaMKII has been implicated in synaptogenesis and…”
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