Search Results - "Zha, DongXing"

Expanding the Range of Substrate Acceptance of Enzymes: Combinatorial Active-Site Saturation Test by Reetz, Manfred T., Bocola, Marco, Carballeira, José Daniel, Zha, Dongxing, Vogel, Andreas

“…CASTing for success: The traditional problem of expanding the range of substrate acceptance of enzymes can be solved by creating focused libraries of mutants…”
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Optimization of humanized IgGs in glycoengineered Pichia pastoris by Gerngross, Tillman U, Li, Huijuan, Sethuraman, Natarajan, Stadheim, Terrance A, Zha, Dongxing, Prinz, Bianka, Ballew, Nicole, Bobrowicz, Piotr, Choi, Byung-Kwon, Cook, W James, Cukan, Michael, Houston-Cummings, Nga Rewa, Davidson, Robert, Gong, Bing, Hamilton, Stephen R, Hoopes, Jack P, Jiang, Youwei, Kim, Nam, Mansfield, Renee, Nett, Juergen H, Rios, Sandra, Strawbridge, Rendall, Wildt, Stefan

“…As the fastest growing class of therapeutic proteins, monoclonal antibodies (mAbs) represent a major potential drug class. Human antibodies are glycosylated in…”
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Overexpression of CD200 is a stem cell-specific mechanism of immune evasion in AML by Herbrich, Shelley, Baran, Natalia, Cai, Tianyu, Weng, Connie, Aitken, Marisa J L, Post, Sean M, Henderson, Jared, Shi, Chunhua, Havranek, Ondrej, Richard-Carpentier, Guillame, Sauvageau, Guy, Baggerly, Keith, Al-Atrash, Gheath, Davis, R Eric, Daver, Naval, Zha, Dongxing, Konopleva, Marina

“…BackgroundAcute myeloid leukemia (AML) stem cells (LSCs) are capable of surviving current standard chemotherapy and are the likely source of deadly, relapsed…”
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Production of monoclonal antibodies by glycoengineered Pichia pastoris by Potgieter, Thomas I., Cukan, Michael, Drummond, James E., Houston-Cummings, Nga Rewa, Jiang, Youwei, Li, Fang, Lynaugh, Heather, Mallem, Muralidhar, McKelvey, Troy W., Mitchell, Teresa, Nylen, Adam, Rittenhour, Alissa, Stadheim, Terrance A., Zha, Dongxing, d’Anjou, Marc

“…The growing antibody market and the pressure to improve productivity as well as reduce cost of production have fueled the development of alternative expression…”
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A Novel T-Cell Engaging Bi-specific Antibody Targeting the Leukemia Antigen PR1/HLA-A2 by Herrmann, Amanda C, Im, Jin S, Pareek, Sumedha, Ruiz-Vasquez, Wilfredo, Lu, Sijie, Sergeeva, Anna, Mehrens, Jennifer, He, Hong, Alatrash, Gheath, Sukhumalchandra, Pariya, St John, Lisa, Clise-Dwyer, Karen, Zha, Dongxing, Molldrem, Jeffrey J

“…Despite substantial advances in the treatment of acute myeloid leukemia (AML), only 30% of patients survive more than 5 years. Therefore, new therapeutics are…”
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A dual-mode surface display system for the maturation and production of monoclonal antibodies in glyco-engineered Pichia pastoris by Shaheen, Hussam H, Prinz, Bianka, Chen, Ming-Tang, Pavoor, Tej, Lin, Song, Houston-Cummings, Nga Rewa, Moore, Renee, Stadheim, Terrance A, Zha, Dongxing

“…State-of-the-art monoclonal antibody (mAb) discovery methods that utilize surface display techniques in prokaryotic and eukaryotic cells require multiple steps…”
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Characterization of the Pichia pastoris protein-O-mannosyltransferase gene family by Nett, Juergen H, Cook, W James, Chen, Ming-Tang, Davidson, Robert C, Bobrowicz, Piotr, Kett, Warren, Brevnova, Elena, Potgieter, Thomas I, Mellon, Mark T, Prinz, Bianka, Choi, Byung-Kwon, Zha, Dongxing, Burnina, Irina, Bukowski, John T, Du, Min, Wildt, Stefan, Hamilton, Stephen R

“…The methylotrophic yeast, Pichiapastoris, is an important organism used for the production of therapeutic proteins. However, the presence of fungal-like…”
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Glycoengineered Pichia produced anti-HER2 is comparable to trastuzumab in preclinical study by Zhang, Ningyan, Liu, Liming, Dan Dumitru, Calin, Cummings, Nga Rewa Houston, Cukan, Michael, Jiang, Youwei, Li, Yuan, Li, Fang, Mitchell, Teresa, Mallem, Muralidhar R., Ou, Yangsi, Patel, Rohan N., Vo, Kim, Wang, Hui, Burnina, Irina, Choi, Byung-Kwon, Huber, Hans E., Stadheim, Terrance A., Zha, Dongxing

“…Mammalian cell culture systems are used predominantly for the production of therapeutic monoclonal antibody (mAb) products. A number of alternative platforms,…”
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A novel fragment of antigen binding (Fab) surface display platform using glycoengineered Pichia pastoris by Lin, Song, Houston-Cummings, Nga Rewa, Prinz, Bianka, Moore, Renée, Bobrowicz, Beata, Davidson, Robert C., Wildt, Stefan, Stadheim, Terrance A., Zha, Dongxing

“…A fragment of antigen binding (Fab) surface display system was developed using a glycoengineered Pichia pastoris host strain genetically modified to secrete…”
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High-throughput screening and selection of yeast cell lines expressing monoclonal antibodies by Barnard, Gavin C, Kull, Angela R, Sharkey, Nathan S, Shaikh, Seemab S, Rittenhour, Alissa M, Burnina, Irina, Jiang, Youwei, Li, Fang, Lynaugh, Heather, Mitchell, Teresa, Nett, Juergen H, Nylen, Adam, Potgieter, Thomas I, Prinz, Bianka, Rios, Sandra E, Zha, Dongxing, Sethuraman, Natarajan, Stadheim, Terrance A, Bobrowicz, Piotr

“…The methylotrophic yeast Pichia pastoris has recently been engineered to express therapeutic glycoproteins with uniform human N-glycans at high titers. In…”
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Unlocking Intracellular Oncology Targets: The Unique Role of Antibody-Based T-Cell Receptor Mimic (TCRm) Therapeutics in T-Cell Engagers (TCEs) and Antibody-Drug Conjugates (ADCs) by Molldrem, Jeffrey, Zha, Dongxing

“…Effectively targeting intracellular tumor-associated proteins presents a formidable challenge in oncology, as they are traditionally considered inaccessible to…”
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Overexpression of CD200 Is a Stem Cell-Specific Mechanism of Immune Escape in AML by Herbrich, Shelley, Baran, Natalia, Alatrash, Gheath, Davis, Eric, Zha, Dongxing, Konopleva, Marina

“…Background: Acute myeloid leukemia (AML) stem cells (LSC), the likely source of relapsed disease, are capable of surviving current standard chemotherapy…”
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Glycoengineered Pichia-based expression of monoclonal antibodies by Zha, Dongxing

“…Currently, mammalian cells are the most commonly used hosts for the production of therapeutic monoclonal antibodies (mAbs). These hosts not only secrete mAbs…”
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AML Immunotherapy Using a Novel Tcrm-Based Bispecific Antibody That Targets a Leader Sequence Peptide Derived from Cathepsin G by Shi, Chunhua, Tian, Ze, Yan, Jun, Zhang, Mao, Sukhumalchandra, Pariya, Chang, Edward, Yang, Guojun, You, Junping, Cui, Meng, Shi, Qing, Philips, Anne, Qiao, Na, Sergeeva, Anna, St. John, Lisa, He, Hong, Zha, Dongxing, Molldrem, Jeffrey J., Alatrash, Gheath

“…Introduction: Myeloid azurophil granules provide a rich source of intracellular leukemia antigens. Cathepsin G (CG) is a serine protease that has higher…”
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Targeting Myeloid Leukemia Using Novel TCR-like Chimeric Antigen Receptor-T Cells Against Cathepsin G by Yan, Jun, Tian, Ze, Shi, Chunhua, Zhang, Mao, Sukhumalchandra, Pariya, Yang, Guojan, Chang, Qing Edward, You, Junping, Cui, Meng, Shi, Qing, Philip, Anne, Qiao, Na, Sergeeva, Anna, St John, Lisa, He, Hong, Zha, Dongxing, Molldrem, Jeffrey J., Alatrash, Gheath

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Preclinical development of 1B7/CD3, a novel anti-TSLPR bispecific antibody that targets CRLF2-rearranged Ph-like B-ALL by Tian, Ze, Shi, Chunhua, Yang, Guojun, Allen, Jason K., Shi, Qing, AL-Shami, Amin, Olson, Jill Wardell, Smith, Melinda G., Chang, Qing, Kaur, Jasbir, You, Junping, Lofton, Timothy E., Gonzalez, Michelle A., Zhang, Qi, Zha, DongXing, Tasian, Sarah K., Jain, Nitin, Konopleva, Marina Y., Heffernan, Timothy, Molldrem, Jeffrey J.

“…Patients harboring CRLF2 -rearranged B-lineage acute lymphocytic leukemia (B-ALL) face a 5-year survival rate as low as 20%. While significant gains have been…”
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Correction: Preclinical development of 1B7/CD3, a novel anti-TSLPR bispecific antibody that targets CRLF2-rearranged Ph-like B-ALL by Tian, Ze, Shi, Chunhua, Yang, Guojun, Allen, Jason K., Shi, Qing, AL-Shami, Amin, Olson, Jill Wardell, Smith, Melinda G., Chang, Qing, Kaur, Jasbir, You, Junping, Lofton, Timothy E., Gonzalez, Michelle A., Zhang, Qi, Zha, DongXing, Tasian, Sarah K., Jain, Nitin, Konopleva, Marina Y., Heffernan, Timothy, Molldrem, Jeffrey J.

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291 Dual-specific antibodies blocking both PD-L1 and PD-L2 engagement of PD-1 restore anti-tumor immunity by Couillault, Coline, Srinivasamani, Anupallavi, Hedge, Shweta, Liu, Qinying, Jaiswal, Ashwin, Zha, Dongxing, Curran, Michael

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Neuropilin-1 mediates neutrophil elastase uptake and cross-presentation in breast cancer cells by Kerros, Celine, Tripathi, Satyendra C., Zha, Dongxing, Mehrens, Jennifer M., Sergeeva, Anna, Philips, Anne V., Qiao, Na, Peters, Haley L., Katayama, Hiroyuki, Sukhumalchandra, Pariya, Ruisaard, Kathryn E., Perakis, Alexander A., St. John, Lisa S., Lu, Sijie, Mittendorf, Elizabeth A., Clise-Dwyer, Karen, Herrmann, Amanda C., Alatrash, Gheath, Toniatti, Carlo, Hanash, Samir M., Ma, Qing, Molldrem, Jeffrey J.

“…Neutrophil elastase (NE) can be rapidly taken up by tumor cells that lack endogenous NE expression, including breast cancer, which results in…”
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Pharmacokinetics of IgG1 monoclonal antibodies produced in humanized Pichia pastoris with specific glycoforms: A comparative study with CHO produced materials by Liu, Liming, Stadheim, Andy, Hamuro, Lora, Pittman, Tamara, Wang, Weirong, Zha, Dongxing, Hochman, Jerome, Prueksaritanont, Thomayant

“…A glycoengineered Pichia pastoris host was used to produce an IgG1 with either afucosylated N-glycosylation (afucosylated biantennary complex) or without…”
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