Search Results - "Zgarbova, Michala"

Ebselen derivatives inhibit SARS-CoV-2 replication by inhibition of its essential proteins: PLpro and Mpro proteases, and nsp14 guanine N7-methyltransferase by Zmudzinski, Mikolaj, Rut, Wioletta, Olech, Kamila, Granda, Jarosław, Giurg, Mirosław, Burda-Grabowska, Małgorzata, Kaleta, Rafał, Zgarbova, Michala, Kasprzyk, Renata, Zhang, Linlin, Sun, Xinyuanyuan, Lv, Zongyang, Nayak, Digant, Kesik-Brodacka, Malgorzata, Olsen, Shaun K., Weber, Jan, Hilgenfeld, Rolf, Jemielity, Jacek, Drag, Marcin

“…Proteases encoded by SARS-CoV-2 constitute a promising target for new therapies against COVID-19. SARS-CoV-2 main protease (M pro , 3CL pro ) and papain-like…”
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Inhibitors of mpox VP39 2′-O methyltransferase efficiently inhibit the monkeypox virus by Zgarbová, Michala, Otava, Tomas, Silhan, Jan, Nencka, Radim, Weber, Jan, Boura, Evzen

“…The RNA 2′-O methyltransferase (MTase) VP39 of the monkeypox virus (MpxV) participates in RNA capping within poxviruses. Sub-micromolar inhibitors targeting…”
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Discovery of Modified Amidate (ProTide) Prodrugs of Tenofovir with Enhanced Antiviral Properties by Kalčic, Filip, Zgarbová, Michala, Hodek, Jan, Chalupský, Karel, Dračínský, Martin, Dvořáková, Alexandra, Strmeň, Timotej, Šebestík, Jaroslav, Baszczyňski, Ondřej, Weber, Jan, Mertlíková-Kaiserová, Helena, Janeba, Zlatko

“…This study describes the discovery of novel prodrugs bearing tyrosine derivatives instead of the phenol moiety present in FDA-approved tenofovir alafenamide…”
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A Helquat-like Compound as a Potent Inhibitor of Flaviviral and Coronaviral Polymerases by Konkolova, Eva, Krejčová, Kateřina, Eyer, Luděk, Hodek, Jan, Zgarbová, Michala, Fořtová, Andrea, Jirasek, Michael, Teply, Filip, Reyes-Gutierrez, Paul E, Růžek, Daniel, Weber, Jan, Boura, Evzen

“…Positive-sense single-stranded RNA (+RNA) viruses have proven to be important pathogens that are able to threaten and deeply damage modern societies, as…”
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Developing Allosteric Inhibitors of SARS-CoV-2 RNA-Dependent RNA Polymerase by Chayka, Artem, Danda, Matěj, Dostálková, Alžběta, Spiwok, Vojtěch, Klimešová, Anna, Kapisheva, Marina, Zgarbová, Michala, Weber, Jan, Ruml, Tomáš, Rumlová, Michaela, Janeba, Zlatko

“…The use of Fpocket and virtual screening techniques enabled us to identify potential allosteric druggable pockets within the SARS-CoV-2 RNA-dependent RNA…”
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Rational Design of Highly Potent SARS-CoV‑2 nsp14 Methyltransferase Inhibitors by Štefek, Milan, Chalupská, Dominika, Chalupský, Karel, Zgarbová, Michala, Dvořáková, Alexandra, Krafčíková, Petra, Li, Alice Shi Ming, Šála, Michal, Dejmek, Milan, Otava, Tomáš, Chaloupecká, Ema, Kozák, Jaroslav, Kozic, Ján, Vedadi, Masoud, Weber, Jan, Mertlíková-Kaiserová, Helena, Nencka, Radim

“…The search for new drugs against COVID-19 and its causative agent, SARS-CoV-2, is one of the major trends in the current medicinal chemistry. Targeting capping…”
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Triterpenoid–PEG Ribbons Targeting Selectivity in Pharmacological Effects by Özdemir, Zulal, Bildziukevich, Uladzimir, Čapková, Martina, Lovecká, Petra, Rárová, Lucie, Šaman, David, Zgarbová, Michala, Lapuníková, Barbora, Weber, Jan, Kazakova, Oxana, Wimmer, Zdeněk

“…(1) Background: To compare the effect of selected triterpenoids with their structurally resembling derivatives, designing of the molecular ribbons was targeted…”
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Ebselen derivatives inhibit SARS-CoV-2 replication by inhibition of its essential proteins: PL pro and M pro proteases, and nsp14 guanine N7-methyltransferase by Zmudzinski, Mikolaj, Rut, Wioletta, Olech, Kamila, Granda, Jarosław, Giurg, Mirosław, Burda-Grabowska, Małgorzata, Kaleta, Rafał, Zgarbova, Michala, Kasprzyk, Renata, Zhang, Linlin, Sun, Xinyuanyuan, Lv, Zongyang, Nayak, Digant, Kesik-Brodacka, Malgorzata, Olsen, Shaun K, Weber, Jan, Hilgenfeld, Rolf, Jemielity, Jacek, Drag, Marcin

“…Proteases encoded by SARS-CoV-2 constitute a promising target for new therapies against COVID-19. SARS-CoV-2 main protease (M , 3CL ) and papain-like protease…”
Get full text