Search Results - "Zeschnigk, M."

Molecular pathology of uveal melanoma by Coupland, S E, Lake, S L, Zeschnigk, M, Damato, B E

“…Like other cancers, uveal melanomas (UM) are characterised by an uncontrolled, clonal, cellular proliferation, occurring as a result of numerous genetic, and…”
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TERT promoter mutations in ocular melanoma distinguish between conjunctival and uveal tumours by Griewank, K G, Murali, R, Schilling, B, Scholz, S, Sucker, A, Song, M, Süsskind, D, Grabellus, F, Zimmer, L, Hillen, U, Steuhl, K-P, Schadendorf, D, Westekemper, H, Zeschnigk, M

“…Background: Recently, activating mutations in the TERT promoter were identified in cutaneous melanoma. We tested a cohort of ocular melanoma samples for…”
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Prognostic significance of chromosome 3 alterations determined by microsatellite analysis in uveal melanoma: a long-term follow-up study by Thomas, S, Pütter, C, Weber, S, Bornfeld, N, Lohmann, D R, Zeschnigk, M

“…Background: In uveal melanoma (UM), the most frequent primary intraocular tumour in adults, loss of one entire chromosome 3 (monosomy 3 (M3)) is observed in…”
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The lung microbiome in patients with pneumocystosis by Kehrmann, J, Veckollari, B, Schmidt, D, Schildgen, O, Schildgen, V, Wagner, N, Zeschnigk, M, Klein-Hitpass, L, Witzke, O, Buer, J, Steinmann, J

“…Pneumocystis jirovecii pneumonia (PCP) is an opportunistic fungal infection that is associated with a high morbidity and mortality in immunocompromised…”
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Clinical and mutation data in 12 patients with the clinical diagnosis of Nager syndrome by Czeschik, J. C., Voigt, C., Alanay, Y., Albrecht, B., Avci, S., FitzPatrick, D., Goudie, D. R., Hehr, U., Hoogeboom, A. J., Kayserili, H., Simsek-Kiper, P. O., Klein-Hitpass, L., Kuechler, A., López-González, V., Martin, M., Rahmann, S., Schweiger, B., Splitt, M., Wollnik, B., Lüdecke, H. -J., Zeschnigk, M., Wieczorek, D.

“…Nager syndrome (MIM #154400) is the best-known preaxial acrofacial dysostosis, mainly characterized by craniofacial and preaxial limb anomalies. The…”
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A novel real-time PCR assay for quantitative analysis of methylated alleles (QAMA): analysis of the retinoblastoma locus by Zeschnigk, Michael, Böhringer, Stefan, Price, Elizabeth Ann, Onadim, Zerrin, Maßhöfer, Lars, Lohmann, Dietmar R.

“…Altered methylation patterns have been found to play a role in developmental disorders, cancer and aging. Increasingly, changes in DNA methylation are used as…”
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Uveal melanoma: current insights into clinical relevance of genetic testing by Metz, C H, Lohmann, D, Zeschnigk, M, Bornfeld, N

“…Uveal melanoma is the most common primary intraocular tumour in Caucasians. There are approximately 500 new cases of uveal melanoma in Germany per year and the…”
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Spectrum of gross deletions and insertions in the RB1 gene in patients with retinoblastoma and association with phenotypic expression by Albrecht, P., Ansperger-Rescher, B., Schüler, A., Zeschnigk, M., Gallie, B., Lohmann, D.R.

“…Quantitative multiplex PCR and genomic real‐time PCR were used to complete an RB1 mutation analysis in 57 of 433 and 72 of 262 patients with hereditary and…”
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Expression of MCSP and PRAME in conjunctival melanoma by Westekemper, Henrike, Karimi, Sara, Süsskind, Daniela, Anastassiou, Gerasimos, Freistühler, Michael, Meller, Daniel, Zeschnigk, Michael, Steuhl, Klaus-Peter, Bornfeld, Norbert, Schmid, Kurt-Werner, Grabellus, Florian

“…To analyse the expression of melanoma chondroitin sulfate proteoglycan (MCSP) and the preferentially expressed antigen of melanoma (PRAME) in conjunctival…”
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Expression pattern of M‐cadherin in normal, denervated, and regenerating mouse muscles by Irintchev, A., Zeschnigk, M., Starzinski‐Powitz, A., Wernig, A.

“…Following muscle damage in adult vertebrates, myofibers can be regenerated from muscle precursor cells (satellite cells). During this process, prenatal…”
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Imprinted Segments in the Human Genome: Different Dna Methylation Patterns in the Prader-Willi/Angelman Syndrome Region As Determined by the Genomic Sequencing Method by Zeschnigk, Michael, Schmitz, Birgit, Dittrich, Bärbel, Buiting, Karin, Horsthemke, Bernhard, Doerfler, Walter

“…A deletion of 15q11-q13 and uniparental disomy 15 lead to Prader-Labhart-Willi syndrome (PWS) or Angelman syndrome (AS) because this region contains genes…”
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Chemosensitivity of conjunctival melanoma cell lines to chemotherapeutic agents by Westekemper, H, Freistuehler, M, Anastassiou, G, Nareyeck, G, Zeschnigk, M, Bornfeld, N, Steuhl, K-P, Scheulen, M E, Hilger, R A

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A PCR test for the detection of hypermethylated alleles at the retinoblastoma locus by ZESCHNIGK, MICHAEL, LOHMANN, DIETMAR, HORSTHEMKE, BERNHARD

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Methylation analysis of the PWS/AS region does not support an enhancer-competition model by Horsthemke, Bernhard, Schumacher, Axel, Buiting, Karin, Zeschnigk, Michael, Doerfler, Walter

“…In a recent article in Nature Genetics, Tilghman et al. propose an enhancer-competition model to explain genomic imprinting in the Prader-Willi/Angelman…”
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Immunotherapy of uveal melanoma: vaccination against cancer. Multicenter adjuvant phase 3 vaccination study using dendritic cells laden with tumor RNA for large newly diagnosed uveal melanoma by Schuler-Thurner, B, Bartz-Schmidt, K-U, Bornfeld, N, Cursiefen, C, Fuisting, B, Grisanti, S, Heindl, L M, Holbach, L, Keserü, M, Knorr, H, Koch, K, Kruse, F, Meiller, R, Metz, C, Meyer-ter-Vehn, T, Much, M, Reinsberg, M, Schliep, S, Seitz, B, Schuler, G, Süsskind, D, Viestenz, A, Wagenfeld, L, Zeschnigk, M

“…Uveal melanomas are the most common malignant tumors of the eye. With modern molecular biological diagnostic methods, such as chromosome 3 typing and gene…”
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Detection of homozygous deletions in tumors by hybridization of representational difference analysis (RDA) products to chromosome-specific YAC clone arrays by Zeschnigk, M, Horsthemke, B, Lohmann, D

“…Representational difference analysis (RDA), a subtractive hybridization method that enriches differences between complex genomes, can be used to isolate…”
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Tumor classification based on gene expression profiling shows that uveal melanomas with and without monosomy 3 represent two distinct entities by TSCHENTSCHER, Frank, HÜSING, Johannes, LOHMANN, Dietmar Rudolf, ZESCHNIGK, Michael, HÖLTER, Tanja, KRUSE, Elisabeth, DRESEN, Irina Gana, JÖCKEL, Karl-Heinz, ANASTASSIOU, Gerasimos, SCHILLING, Harald, BORNFELD, Norbert, HORSTHEMKE, Bernhard

“…Uveal melanoma is the most common intraocular malignancy. About 50% of patients die of metastases, which almost exclusively originate from primary tumors that…”
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Methylation and Silencing of the Retinoic Acid Receptor-β2 Gene in Breast Cancer by Widschwendter, Martin, Berger, Jennifer, Hermann, Martin, Müller, Hannes M., Amberger, Albert, Zeschnigk, Michael, Widschwendter, Andreas, Abendstein, Burghard, Zeimet, Alain G., Daxenbichler, Günter, Marth, Christian

“…Background: A growing body of evidence supports the hypotheses that the retinoic acid receptor β2 (RAR-β2) gene is a tumor suppressor gene and that the…”
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Somatic mosaicism in patients with Angelman syndrome and an imprinting defect by Nazlican, Hülya, Zeschnigk, Michael, Claussen, Uwe, Michel, Susanne, Boehringer, Stefan, Gillessen-Kaesbach, Gabriele, Buiting, Karin, Horsthemke, Bernhard

“…Angelman syndrome is a neurogenetic disorder caused by the loss of function of the imprinted UBE3A gene in 15q11–q13. In a small group of patients, the disease…”
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Loss of heterozygosity of 1p in uveal melanomas with monosomy 3 by Häusler, Thomas, Stang, Andreas, Anastassiou, Gerasimos, Jöckel, Karl‐Heinz, Mrzyk, Stefanie, Horsthemke, Bernhard, Lohmann, Dietmar R., Zeschnigk, Michael

“…Gains and losses of chromosomes 1, 3, 6 and 8 are nonrandom chromosomal aberrations in uveal melanoma. Monosomy 3 is the most frequent abnormality and is…”
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