Search Results - "Zervopoulos, Sotirios D."

Metabolic Enzymes Moonlighting in the Nucleus: Metabolic Regulation of Gene Transcription by Boukouris, Aristeidis E., Zervopoulos, Sotirios D., Michelakis, Evangelos D.

“…During evolution, cells acquired the ability to sense and adapt to varying environmental conditions, particularly in terms of fuel supply. Adaptation to fuel…”
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SNPs for Genes Encoding the Mitochondrial Proteins Sirtuin3 and Uncoupling Protein 2 Are Associated With Disease Severity, Type 2 Diabetes, and Outcomes in Patients With Pulmonary Arterial Hypertension and This Is Recapitulated in a New Mouse Model Lacking Both Genes by Zhang, Yongneng, Zervopoulos, Sotirios D, Boukouris, Aristeidis E, Lorenzana-Carrillo, Maria Areli, Saleme, Bruno, Webster, Linda, Liu, Yongsheng, Haromy, Alois, Tabatabaei Dakhili, Seyed Amirhossein, Ussher, John R, Sutendra, Gopinath, Michelakis, Evangelos D

“…Background Isolated loss-of-function single nucleotide polymorphisms (SNPs) for (a mitochondrial deacetylase) and (an atypical uncoupling protein enabling…”
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MFN2-driven mitochondria-to-nucleus tethering allows a non-canonical nuclear entry pathway of the mitochondrial pyruvate dehydrogenase complex by Zervopoulos, Sotirios D., Boukouris, Aristeidis E., Saleme, Bruno, Haromy, Alois, Tejay, Saymon, Sutendra, Gopinath, Michelakis, Evangelos D.

“…The mitochondrial pyruvate dehydrogenase complex (PDC) translocates into the nucleus, facilitating histone acetylation by producing acetyl-CoA. We describe a…”
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Interaction with p53 explains a pro-proliferative function for VHL in cancer by Kinnaird, Adam, Boukouris, Aristeidis E., Saleme, Bruno, Dromparis, Peter, Zervopoulos, Sotirios D., Gurtu, Vikram, Sutendra, Gopinath, Michelakis, Evangelos D.

“…The von Hippel-Lindau (VHL) protein binds and degrades hypoxia-inducible factors (HIF) hydroxylated by prolyl-hydroxylases under normoxia. Although originally…”
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A reversible metabolic stress-sensitive regulation of CRMP2A orchestrates EMT/stemness and increases metastatic potential in cancer by Boukouris, Aristeidis E., Zhang, Yongneng, Saleme, Bruno, Kinnaird, Adam, Zhao, Yuan Yuan, Liu, Yongsheng, Zervopoulos, Sotirios D., Das, Subhash K., Mittal, Rohan D., Haromy, Alois, Lorenzana-Carrillo, Maria Areli, Krysler, Amanda R., Cromwell, Christopher R., Hubbard, Basil P., Sutendra, Gopinath, Michelakis, Evangelos D.

“…An epithelial-to-mesenchymal transition (EMT) phenotype with cancer stem cell-like properties is a critical feature of aggressive/metastatic tumors, but the…”
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Abstract 13575: Lack of Both Mitochondrial Proteins Sirt3 and Ucp2 in Mice Recapitulates Many Critical Features of Human Pulmonary Arterial Hypertension (PAH), Including Inflammatory Plexogenic Lesions, Supporting the Metabolic Theory of PAH by Zhang, Yongneng, Zervopoulos, Sotirios D, Boukouris, Aristeidis E, Saleme, Bruno, Liu, Yongsheng, Haromy, Alois, Webster, Linda, Tabatabaei Dakhili, Seyed Amirhossein, Ussher, John R, Sutendra, Gopinath, Michelakis, Evangelos D

“…Loss-of function SNPs for Sirt3 (a mitochondrial deacetylase) and Ucp2 (an atypical uncoupling protein enabling mitochondrial calcium entry) have been…”
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