Search Results - "Zerbe, Oliver"

First Solution Structures of Seven-Transmembrane Helical Proteins by Zerbe, Oliver

“…A mastered challenge: The recent solution structures of seven‐transmembrane proteins, in particular of proteorhodopsin, have been reported. The structures are…”
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Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery by Fumagalli, Fiorenza, Noack, Julia, Bergmann, Timothy J., Cebollero, Eduardo, Pisoni, Giorgia Brambilla, Fasana, Elisa, Fregno, Ilaria, Galli, Carmela, Loi, Marisa, Soldà, Tatiana, D’Antuono, Rocco, Raimondi, Andrea, Jung, Martin, Melnyk, Armin, Schorr, Stefan, Schreiber, Anne, Simonelli, Luca, Varani, Luca, Wilson-Zbinden, Caroline, Zerbe, Oliver, Hofmann, Kay, Peter, Matthias, Quadroni, Manfredo, Zimmermann, Richard, Molinari, Maurizio

“…The endoplasmic reticulum (ER) is a site of protein biogenesis in eukaryotic cells. Perturbing ER homeostasis activates stress programs collectively called the…”
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Peptide‐Guided Assembly of Repeat Protein Fragments by Michel, Erich, Plückthun, Andreas, Zerbe, Oliver

“…Herein, we present the peptide‐guided assembly of complementary fragments of designed armadillo repeat proteins (dArmRPs) to create proteins that bind peptides…”
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Early Molecular Insights into Thanatin Analogues Binding to A. baumannii LptA by Oi, Kathryn K, Moehle, Kerstin, Schuster, Matthias, Zerbe, Oliver

“…The cationic antimicrobial ß-hairpin, thanatin, was recently developed into drug-like analogues active against carbapenem-resistant Enterobacteriaceae (CRE)…”
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Soft biomimetic nanoconfinement promotes amorphous water over ice by Salvati Manni, Livia, Assenza, Salvatore, Duss, Michael, Vallooran, Jijo J., Juranyi, Fanni, Jurt, Simon, Zerbe, Oliver, Landau, Ehud M., Mezzenga, Raffaele

“…Water is a ubiquitous liquid with unique physicochemical properties, whose nature has shaped our planet and life as we know it. Water in restricted geometries…”
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Peptide binding affinity redistributes preassembled repeat protein fragments by Michel, Erich, Plückthun, Andreas, Zerbe, Oliver

“…Designed armadillo repeat proteins (dArmRPs) are modular peptide binders composed of N- and C-terminal capping repeats Y and A and a variable number of…”
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An automated iterative approach for protein structure refinement using pseudocontact shifts by Cucuzza, Stefano, Güntert, Peter, Plückthun, Andreas, Zerbe, Oliver

“…NMR structure calculation using NOE-derived distance restraints requires a considerable number of assignments of both backbone and sidechains resonances, often…”
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Unexpected dynamics in femtomolar complexes of binding proteins with peptides by Cucuzza, Stefano, Sitnik, Malgorzata, Jurt, Simon, Michel, Erich, Dai, Wenzhao, Müntener, Thomas, Ernst, Patrick, Häussinger, Daniel, Plückthun, Andreas, Zerbe, Oliver

“…Ultra-tight binding is usually observed for proteins associating with rigidified molecules. Previously, we demonstrated that femtomolar binders derived from…”
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Dynamics of Bacteriorhodopsin in the Dark‐Adapted State from Solution Nuclear Magnetic Resonance Spectroscopy by Kooijman, Laurens, Schuster, Matthias, Baumann, Christian, Jurt, Simon, Löhr, Frank, Fürtig, Boris, Güntert, Peter, Zerbe, Oliver

“…To achieve efficient proton pumping in the light‐driven proton pump bacteriorhodopsin (bR), the protein must be tightly coupled to the retinal to rapidly…”
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Kinetic response of a photoperturbed allosteric protein by Buchli, Brigitte, Waldauer, Steven A., Walser, Reto, Donten, Mateusz L., Pfister, Rolf, Blöchliger, Nicolas, Steiner, Sandra, Caflisch, Amedeo, Zerbe, Oliver, Hamm, Peter

“…By covalently linking an azobenzene photoswitch across the binding groove of a PDZ domain, a conformational transition, similar to the one occurring upon…”
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Crystal structure of the α1B-adrenergic receptor reveals molecular determinants of selective ligand recognition by Deluigi, Mattia, Morstein, Lena, Schuster, Matthias, Klenk, Christoph, Merklinger, Lisa, Cridge, Riley R., de Zhang, Lazarus A., Klipp, Alexander, Vacca, Santiago, Vaid, Tasneem M., Mittl, Peer R. E., Egloff, Pascal, Eberle, Stefanie A., Zerbe, Oliver, Chalmers, David K., Scott, Daniel J., Plückthun, Andreas

“…α-adrenergic receptors (αARs) are G protein-coupled receptors that regulate vital functions of the cardiovascular and nervous systems. The therapeutic…”
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Mistic's membrane association and its assistance in overexpression of a human GPCR are independent processes by Marino, Jacopo, Bordag, Natalie, Keller, Sandro, Zerbe, Oliver

“…The interaction of the Bacillus subtilis protein Mistic with the bacterial membrane and its role in promoting the overexpression of other membrane proteins are…”
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Interactions of Lipopolysaccharide and Polymyxin Studied by NMR Spectroscopy by Mares, Jiri, Kumaran, Sowmini, Gobbo, Marina, Zerbe, Oliver

“…In the light of occurrence of bacterial strains with multiple resistances against most antibiotics, antimicrobial peptides that interact with the outer layer…”
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Distinct pathways for zinc metabolism in the terrestrial slug Arion vulgaris by Dvorak, Martin, Schnegg, Raimund, Salvenmoser, Willy, Palacios, Òscar, Lindner, Herbert, Zerbe, Oliver, Hansel, Armin, Leiminger, Markus, Steiner, Gerhard, Dallinger, Reinhard, Lackner, Reinhard

“…In most organisms, the concentration of free Zn 2+ is controlled by metallothioneins (MTs). In contrast, no significant proportions of Zn 2+ are bound to MTs…”
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Biomphalaria glabrata Metallothionein: Lacking Metal Specificity of the Protein and Missing Gene Upregulation Suggest Metal Sequestration by Exchange Instead of through Selective Binding by Niederwanger, Michael, Calatayud, Sara, Zerbe, Oliver, Atrian, Sílvia, Albalat, Ricard, Capdevila, Mercè, Palacios, Òscar, Dallinger, Reinhard

“…The wild-type metallothionein (MT) of the freshwater snail and a natural allelic mutant of it in which a lysine residue was replaced by an asparagine residue,…”
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Peptides in BioNMR Research by Zerbe, Oliver, Baumann, Christian, Schuster, Matthias, Moehle, Kerstin, Oi, Kathryn K., Michel, Erich

“…Heteronuclear NMR in combination with isotope labelling is used to study folding of polypeptides induced by metals in the case of metallothioneins, binding of…”
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Analysis of Metal-Binding Features of the Wild Type and Two Domain-Truncated Mutant Variants of Littorina littorea Metallothionein Reveals Its Cd-Specific Character by Palacios, Òscar, Jiménez-Martí, Elena, Niederwanger, Michael, Gil-Moreno, Selene, Zerbe, Oliver, Atrian, Sílvia, Dallinger, Reinhard, Capdevila, Mercè

“…After the resolution of the 3D structure of the Cd₉-aggregate of the metallothionein (MT), we report here a detailed analysis of the metal binding capabilities…”
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Computationally Designed Armadillo Repeat Proteins for Modular Peptide Recognition by Reichen, Christian, Hansen, Simon, Forzani, Cristina, Honegger, Annemarie, Fleishman, Sarel J., Zhou, Ting, Parmeggiani, Fabio, Ernst, Patrick, Madhurantakam, Chaithanya, Ewald, Christina, Mittl, Peer R.E., Zerbe, Oliver, Baker, David, Caflisch, Amedeo, Plückthun, Andreas

“…Armadillo repeat proteins (ArmRPs) recognize their target peptide in extended conformation and bind, in a first approximation, two residues per repeat. Thus,…”
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Optimization of designed armadillo repeat proteins by molecular dynamics simulations and NMR spectroscopy by Alfarano, Pietro, Varadamsetty, Gautham, Ewald, Christina, Parmeggiani, Fabio, Pellarin, Riccardo, Zerbe, Oliver, Plückthun, Andreas, Caflisch, Amedeo

“…A multidisciplinary approach based on molecular dynamics (MD) simulations using homology models, NMR spectroscopy, and a variety of biophysical techniques was…”
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Structural and Biochemical Studies on Procaspase-8: New Insights on Initiator Caspase Activation by Keller, Nadine, Mareš, Jiří, Zerbe, Oliver, Grütter, Markus G.

“…Caspases are proteases with an active-site cysteine and aspartate specificity in their substrates. They are involved in apoptotic cell death and inflammation,…”
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