Search Results - "Zerbato, Jennifer M."

Integration in oncogenes plays only a minor role in determining the in vivo distribution of HIV integration sites before or during suppressive antiretroviral therapy by Coffin, John M, Bale, Michael J, Wells, Daria, Guo, Shuang, Luke, Brian, Zerbato, Jennifer M, Sobolewski, Michele D, Sia, Twan, Shao, Wei, Wu, Xiaolin, Maldarelli, Frank, Kearney, Mary F, Mellors, John W, Hughes, Stephen H

“…HIV persists during antiretroviral therapy (ART) as integrated proviruses in cells descended from a small fraction of the CD4+ T cells infected prior to the…”
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Reprogrammed CRISPR-Cas13b suppresses SARS-CoV-2 replication and circumvents its mutational escape through mismatch tolerance by Fareh, Mohamed, Zhao, Wei, Hu, Wenxin, Casan, Joshua M. L., Kumar, Amit, Symons, Jori, Zerbato, Jennifer M., Fong, Danielle, Voskoboinik, Ilia, Ekert, Paul G., Rudraraju, Rajeev, Purcell, Damian F. J., Lewin, Sharon R., Trapani, Joseph A.

“…The recent dramatic appearance of variants of concern of SARS-coronavirus-2 (SARS-CoV-2) highlights the need for innovative approaches that simultaneously…”
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Combination Immune Checkpoint Blockade to Reverse HIV Latency by Van der Sluis, Renée M, Kumar, Nitasha A, Pascoe, Rachel D, Zerbato, Jennifer M, Evans, Vanessa A, Dantanarayana, Ashanti I, Anderson, Jenny L, Sékaly, Rafick P, Fromentin, Rémi, Chomont, Nicolas, Cameron, Paul U, Lewin, Sharon R

“…In people living with HIV on antiretroviral therapy, HIV latency is the major barrier to a cure. HIV persists preferentially in CD4 T cells expressing multiple…”
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Diverse effects of interferon alpha on the establishment and reversal of HIV latency by Van der Sluis, Renée M, Zerbato, Jennifer M, Rhodes, Jake W, Pascoe, Rachel D, Solomon, Ajantha, Kumar, Nitasha A, Dantanarayana, Ashanti I, Tennakoon, Surekha, Dufloo, Jérémy, McMahon, James, Chang, Judy J, Evans, Vanessa A, Hertzog, Paul J, Jakobsen, Martin R, Harman, Andrew N, Lewin, Sharon R, Cameron, Paul U

“…HIV latency is the major barrier to a cure for people living with HIV (PLWH) on antiretroviral therapy (ART) because the virus persists in long-lived…”
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Intrahepatic CXCL10 is strongly associated with liver fibrosis in HIV-Hepatitis B co-infection by Singh, Kasha P, Zerbato, Jennifer M, Zhao, Wei, Braat, Sabine, Deleage, Claire, Tennakoon, G Surekha, Mason, Hugh, Dantanarayana, Ashanti, Rhodes, Ajantha, Rhodes, Jake W, Torresi, Joe, Harman, Andrew N, Revill, Peter A, Crane, Megan, Estes, Jacob D, Avihingsanon, Anchalee, Lewin, Sharon R, Audsley, Jennifer

“…In HIV-hepatitis B virus (HBV) co-infection, adverse liver outcomes including liver fibrosis occur at higher frequency than in HBV-mono-infection, even…”
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Clones of infected cells arise early in HIV-infected individuals by Coffin, John M, Wells, David W, Zerbato, Jennifer M, Kuruc, Joann D, Guo, Shuang, Luke, Brian T, Eron, Joseph J, Bale, Michael, Spindler, Jonathan, Simonetti, Francesco R, Hill, Shawn, Kearney, Mary F, Maldarelli, Frank, Wu, Xiaolin, Mellors, John W, Hughes, Stephen H

“…In HIV-infected individuals on long-term antiretroviral therapy (ART), more than 40% of the infected cells are in clones. Although most HIV proviruses present…”
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Multiply spliced HIV RNA is a predictive measure of virus production ex vivo and in vivo following reversal of HIV latency by Zerbato, Jennifer M., Khoury, Georges, Zhao, Wei, Gartner, Matthew J., Pascoe, Rachel D., Rhodes, Ajantha, Dantanarayana, Ashanti, Gooey, Megan, Anderson, Jenny, Bacchetti, Peter, Deeks, Steven G., McMahon, James, Roche, Michael, Rasmussen, Thomas A., Purcell, Damian FJ, Lewin, Sharon R.

“…One strategy being pursued to clear latently infected cells that persist in people living with HIV (PLWH) on antiretroviral therapy (ART) is to activate latent…”
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Enhancement of antibody class-switch recombination by the cumulative activity of four separate elements by Dunnick, Wesley A, Shi, Jian, Zerbato, Jennifer M, Fontaine, Clinton A, Collins, John T

“…Class-switch recombination of Ab isotype is mediated by a recombinational DNA deletion event and must be robustly upregulated during Ag-driven differentiation…”
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Naive CD4+ T Cells Harbor a Large Inducible Reservoir of Latent, Replication-competent Human Immunodeficiency Virus Type 1 by Zerbato, Jennifer M, McMahon, Deborah K, Sobolewski, Michelle D, Mellors, John W, Sluis-Cremer, Nicolas

“…Abstract Background The latent human immunodeficiency virus type 1 (HIV-1) reservoir represents a major barrier to a cure. Based on the levels of HIV-1 DNA in…”
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Between a shock and a hard place: challenges and developments in HIV latency reversal by Zerbato, Jennifer M, Purves, Harrison V, Lewin, Sharon R, Rasmussen, Thomas A

“…[Display omitted] •HIV latency persists in long-lived and proliferating CD4+ T cells.•Latency is maintained through mechanisms that suppress viral…”
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Novel assay reveals a large, inducible, replication-competent HIV-1 reservoir in resting CD4+ T cells by Sanyal, Anwesha, Mailliard, Robbie B, Rinaldo, Charles R, Ratner, Deena, Ding, Ming, Chen, Yue, Zerbato, Jennifer M, Giacobbi, Nicholas S, Venkatachari, Narasimhan J, Patterson, Bruce K, Chargin, Amanda, Sluis-Cremer, Nicolas, Gupta, Phalguni

“…Sanyal et al . report a new and rapid assay for measuring replication-competent HIV-1 in CD4 + T cells. Although antiretroviral therapy can suppress HIV-1…”
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Markers of Immune Activation and Inflammation Are Associated with Higher Levels of Genetically-Intact HIV in HIV-HBV Co-Infected Individuals by Wang, Xiao Qian, Zerbato, Jennifer M., Avihingsanon, Anchalee, Fisher, Katie, Schlub, Timothy, Rhodes, Ajantha, Audsley, Jennifer, Singh, Kasha P., Zhao, Wei, Lewin, Sharon R., Palmer, Sarah

“…Co-infection with hepatitis B (HBV) and human immunodeficiency virus (HIV) increases overall and liver-related mortality. In order to identify interactions…”
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Nonnucleoside Reverse Transcriptase Inhibitors Reduce HIV-1 Production from Latently Infected Resting CD4 + T Cells following Latency Reversal by Zerbato, Jennifer M, Tachedjian, Gilda, Sluis-Cremer, Nicolas

“…Therapeutic strategies that target the latent HIV-1 reservoir in resting CD4 T cells of infected individuals are always administered in the presence of…”
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The impact of immune checkpoint therapy on the latent reservoir in HIV-infected individuals with cancer on antiretroviral therapy by Lau, Jillian S.Y., McMahon, James H., Gubser, Celine, Solomon, Ajantha, Chiu, Chris Y.H., Dantanarayana, Ashanti, Chea, Socheata, Tennakoon, Surekha, Zerbato, Jennifer M., Garlick, Jill, Morcilla, Vincent, Palmer, Sarah, Lewin, Sharon R., Rasmussen, Thomas A.

“…To quantify HIV specific immunological and virological changes in people living with HIV (PLWH) on antiretroviral therapy (ART) with malignancy who received…”
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Establishment and Reversal of HIV-1 Latency in Naive and Central Memory CD4+ T Cells In Vitro by Zerbato, Jennifer M, Serrao, Erik, Lenzi, Gina, Kim, Baek, Ambrose, Zandrea, Watkins, Simon C, Engelman, Alan N, Sluis-Cremer, Nicolas

“…The latent HIV-1 reservoir primarily resides in resting CD4(+) T cells which are a heterogeneous population composed of both naive (TN) and memory cells. In…”
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Persistence of envelopes in different CD4 + T-cell subsets in antiretroviral therapy-suppressed people with HIV by Gartner, Matthew J., Tumpach, Carolin, Dantanarayana, Ashanti, Stern, Jared, Zerbato, Jennifer M., Chang, J. Judy, Angelovich, Thomas A., Anderson, Jenny L., Symons, Jori, Deeks, Steve G., Flynn, Jacqueline K., Lewin, Sharon R., Churchill, Melissa J., Gorry, Paul R., Roche, Michael

“…Despite suppressive antiretroviral therapy (ART), HIV can persist in a diverse range of CD4+ T-cell subsets. Through longitudinal env sampling from people with…”
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Factors associated with weak positive SARS-CoV-2 diagnosis by reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR) by Rawat, Priyank, Zerbato, Jennifer M., Rhodes, Ajantha, Chiu, Chris, Tran, Thomas, Rasmussen, Thomas A., Druce, Julian, Lewin, Sharon R., Roche, Michael

“…During the COVID-19 pandemic, the reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR) assay has been the primary method of diagnosis of…”
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A cure for HIV: how would we know? by Zerbato, Jennifer M, Lewin, Sharon R

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Neurotoxicity with high-dose disulfiram and vorinostat used for HIV latency reversal by McMahon, James H., Evans, Vanessa A., Lau, Jillian S.Y., Symons, Jori, Zerbato, Jennifer M., Chang, Judy, Solomon, Ajantha, Tennakoon, Surekha, Dantanarayana, Ashanti, Hagenauer, Michelle, Lee, Sulggi, Palmer, Sarah, Fisher, Katie, Bumpus, Namandje, Heck, Carley J.S., Burger, David, Wu, Guoxin, Zuck, Paul, Howell, Bonnie J., Zetterberg, Henrik H., Blennow, Kaj, Gisslen, Magnus, Rasmussen, Thomas A., Lewin, Sharon R.

“…The aim of this study was to examine whether administering both vorinostat and disulfiram to people with HIV (PWH) on antiretroviral therapy (ART) is well…”
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HIV DNA persists in hepatocytes in people with HIV-hepatitis B co-infection on antiretroviral therapy by Zerbato, Jennifer M., Avihingsanon, Anchalee, Singh, Kasha P., Zhao, Wei, Deleage, Claire, Rosen, Elias, Cottrell, Mackenzie L., Rhodes, Ajantha, Dantanarayana, Ashanti, Tumpach, Carolin, Tennakoon, Surekha, Crane, Megan, Price, David J., Braat, Sabine, Mason, Hugh, Roche, Michael, Kashuba, Angela D.M., Revill, Peter A., Audsley, Jennifer, Lewin, Sharon R.

“…HIV can infect multiple cells in the liver including hepatocytes, Kupffer cells and infiltrating T cells, but whether HIV can persist in the liver in people…”
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