Search Results - "Zentsova, Irena"

Immunoprofiling of monocytes in STAT1 gain-of-function chronic mucocutaneous candidiasis by Bloomfield, Marketa, Zentsova, Irena, Milota, Tomas, Sediva, Anna, Parackova, Zuzana

“…Patients with STAT1 gain-of-function (GOF) mutations suffer from an inborn error of immunity hallmarked by chronic mucocutaneous candidiasis (CMC). The…”
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Neutrophil Extracellular Trap Induced Dendritic Cell Activation Leads to Th1 Polarization in Type 1 Diabetes by Parackova, Zuzana, Zentsova, Irena, Vrabcova, Petra, Klocperk, Adam, Sumnik, Zdenek, Pruhova, Stepanka, Petruzelkova, Lenka, Hasler, Robert, Sediva, Anna

“…Neutrophils releasing neutrophil extracellular traps (NETs) infiltrate the pancreas prior to type 1 diabetes (T1D) onset; however, the precise nature of their…”
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Disharmonic Inflammatory Signatures in COVID-19: Augmented Neutrophils' but Impaired Monocytes' and Dendritic Cells' Responsiveness by Parackova, Zuzana, Zentsova, Irena, Bloomfield, Marketa, Vrabcova, Petra, Smetanova, Jitka, Klocperk, Adam, Mesežnikov, Grigorij, Casas Mendez, Luis Fernando, Vymazal, Tomas, Sediva, Anna

“…COVID-19, caused by SARS-CoV-2 virus, emerged as a pandemic disease posing a severe threat to global health. To date, sporadic studies have demonstrated that…”
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Utility of Ruxolitinib in a Child with Chronic Mucocutaneous Candidiasis Caused by a Novel STAT1 Gain-of-Function Mutation by Bloomfield, Markéta, Kanderová, Veronika, Paračková, Zuzana, Vrabcová, Petra, Svatoň, Michael, Froňková, Eva, Fejtková, Martina, Zachová, Radana, Rataj, Michal, Zentsová, Irena, Milota, Tomáš, Klocperk, Adam, Kalina, Tomáš, Šedivá, Anna

“…Purpose Signal transducer and activator of transcription 1 gain-of-function (STAT1 GOF) mutations are the most common cause of chronic mucocutaneous…”
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Expanded population of low-density neutrophils in juvenile idiopathic arthritis by Parackova, Zuzana, Zentsova, Irena, Bloomfield, Marketa, Klocperk, Adam, Horvath, Rudolf, Malcova, Hana, Cebecauerova, Dita, Sediva, Anna

“…IntroductionJuvenile idiopathic arthritis (JIA), a clinically variable disease characterized by autoimmune arthritis, affects children, and its immunopathology…”
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Elevated Biomarkers of NETosis in the Serum of Pediatric Patients With Type 1 Diabetes and Their First-Degree Relatives by Klocperk, Adam, Vcelakova, Jana, Vrabcova, Petra, Zentsova, Irena, Petruzelkova, Lenka, Sumnik, Zdenek, Pruhova, Stepanka, Sediva, Anna, Parackova, Zuzana

“…Type 1 diabetes (T1D) is an autoimmune disorder with unambiguous involvement of both innate and adaptive immune mechanisms in the destruction of pancreatic…”
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Lymphoproliferation, immunodeficiency and early-onset inflammatory bowel disease associated with a novel mutation in Caspase 8 by Kanderova, Veronika, Grombirikova, Hana, Zentsova, Irena, Reblova, Kamila, Klocperk, Adam, Fejtkova, Martina, Bloomfield, Marketa, Ravcukova, Barbora, Kalina, Tomas, Freiberger, Tomas, Sediva, Anna

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Increased histone citrullination in juvenile idiopathic arthritis by Parackova, Zuzana, Zentsova, Irena, Malcova, Hana, Cebecauerova, Dita, Sediva, Anna, Horvath, Rudolf

“…ObjectivePosttranslational modifications (PTMs) of proteins are crucial for regulating various biological processes. However, protein alteration via PTMs, and…”
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Mutual alteration of NOD2-associated Blau syndrome and IFNγR1 deficiency by Parackova, Zuzana, Bloomfield, Marketa, Vrabcova, Petra, Zentsova, Irena, Klocperk, Adam, Milota, Tomas, Svaton, Michael, Casanova, Jean-Laurent, Bustamante, Jacinta, Fronkova, Eva, Sediva, Anna

“…Blau syndrome (BS) is an auto-inflammatory granulomatous disease that possibly involves abnormal response to interferon gamma (IFNγ) due to exaggerated…”
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Data on microbial DNA-induced IL-1β production in monocytes of type 1 diabetes patients by Zentsova, Irena, Parackova, Zuzana, Kayserova, Jana, Palova-Jelinkova, Lenka, Vrabcova, Petra, Volfova, Nikol, Sumnik, Zdenek, Pruhova, Stepanka, Petruzelkova, Lenka, Sediva, Anna

“…Inflammasomes are large protein complexes involved in the maturation of IL-1β, a cytokine associated with the pathophysiology of type 1 diabetes (T1D). The…”
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Aberrant tolerogenic functions and proinflammatory skew of dendritic cells in STAT1 gain-of-function patients may contribute to autoimmunity and fungal susceptibility by Parackova, Zuzana, Zentsova, Irena, Vrabcova, Petra, Sediva, Anna, Bloomfield, Marketa

“…STAT1 gain-of-function (GOF) mutations underlie an inborn error of immunity hallmarked by chronic mucocutaneous candidiasis (CMC). Beyond the fungal…”
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Neutrophils in STAT1 Gain-Of-Function Have a Pro-inflammatory Signature Which Is Not Rescued by JAK Inhibition by Parackova, Zuzana, Vrabcova, Petra, Zentsova, Irena, Sediva, Anna, Bloomfield, Marketa

“…STAT1 gain-of-function (GOF) mutations cause an inborn error of immunity with diverse phenotype ranging from chronic mucocutaneous candidiasis (CMC) to various…”
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Innate immune side of STAT1 GOF by Šedivá, Anna, Parackova, Zuzana, Zentsova, Irena, Vrabcova, Petra, Bloomfield, Marketa

“…STAT1 gain-of-function (GOF) mutations underlie an inborn error of immunity hallmarked by chronic mucocutaneous candidiasis (CMC). Beyond the fungal…”
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Immunomodulation of neutrophils and platelets by TNF blockage in patients with juvenile idiopathic arthritis by Parackova, Zuzana, Zentsova, Irena, Horvath, Rudolf, Malcova, Hana, Cebecauerova, Dita, Sediva, Anna, Klocperk, Adam

“…Juvenile idiopathic arthritis (JIA) is a multifactorial autoimmune disease mediated by both adaptive and innate immunity. The role of neutrophils in the…”
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Tumor-necrosis factor α-rich environment alters type-I interferon response to viral stimuli in patients with juvenile idiopathic arthritis by altering myeloid dendritic cell phenotype by Zentsova, Irena, Klocperk, Adam, Bloomfield, Marketa, Kubesova, Helena, Malcova, Hana, Cebecauerova, Dita, Horvath, Rudolf, Sediva, Anna, Parackova, Zuzana

“…The balance between the tumor-necrosis factor α (TNFα) and type-I interferon (T1IFN) pathways is crucial for proper immune function. Dysregulation of either…”
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Monocytes contribute to DNA sensing through the TBK1 signaling pathway in type 1 diabetes patients by Zentsova, Irena, Parackova, Zuzana, Kayserova, Jana, Palova-Jelinkova, Lenka, Vrabcova, Petra, Volfova, Nikol, Sumnik, Zdenek, Pruhova, Stepanka, Petruzelkova, Lenka, Sediva, Anna

“…The aberrant recognition of self-nucleic acids by the innate immune system contributes to the pathology of several autoimmune diseases. Although microbial DNA…”
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Ants as Ecosystem Engineers in Natural Restoration of Human Made Habitats by Kovář, Pavel, Vojtíšek, Pavel, Zentsová, Irena

“…Three to four dominant seed-transporting ant species of different size categories (Tetramorium caespitum, Lasius niger, Formica rufibarbis/Formica pratensis)…”
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Alteration of B cell subsets and the receptor for B cell activating factor (BAFF) in paediatric patients with type 1 diabetes by Parackova, Zuzana, Klocperk, Adam, Rataj, Michal, Kayserova, Jana, Zentsova, Irena, Sumnik, Zdenek, Kolouskova, Stanislava, Sklenarova, Jana, Pruhova, Stepanka, Obermannova, Barbora, Petruzelkova, Lenka, Lebl, Jan, Kalina, Tomas, Sediva, Anna

“…Highlights • Paediatric T1D patients have lower transitional B lymphocytes. • Relatives of T1D patients and patients in recent-onset have increased…”
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Complex Immunometabolic Profiling Reveals the Activation of Cellular Immunity and Biliary Lesions in Patients with Severe COVID-19 by Klocperk, Adam, Bloomfield, Marketa, Parackova, Zuzana, Zentsova, Irena, Vrabcova, Petra, Balko, Jan, Meseznikov, Grigorij, Casas Mendez, Luis Fernando, Grandcourtova, Alzbeta, Sipek, Jan, Tulach, Martin, Zamecnik, Josef, Vymazal, Tomas, Sediva, Anna

“…This study aimed to assess the key laboratory features displayed by coronavirus disease 2019 (COVID-19) inpatients that are associated with mild, moderate,…”
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Lymphoproliferation, immunodeficiency and early-onset inflammatory bowel disease associated with a novel mutation in Caspase 8 by Kanderova, Veronika, Grombirikova, Hana, Zentsova, Irena, Reblova, Kamila, Klocperk, Adam, Fejtkova, Martina, Bloomfield, Marketa, Ravcukova, Barbora, Kalina, Tomas, Freiberger, Tomas, Sediva, Anna

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