Search Results - "Zentilin, Lorena"

Functional screening identifies miRNAs inducing cardiac regeneration by Eulalio, Ana, Mano, Miguel, Ferro, Matteo Dal, Zentilin, Lorena, Sinagra, Gianfranco, Zacchigna, Serena, Giacca, Mauro

“…In mammals, enlargement of the heart during embryonic development is primarily dependent on the increase in cardiomyocyte numbers. Shortly after birth,…”
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MicroRNA therapy stimulates uncontrolled cardiac repair after myocardial infarction in pigs by Gabisonia, Khatia, Prosdocimo, Giulia, Aquaro, Giovanni Donato, Carlucci, Lucia, Zentilin, Lorena, Secco, Ilaria, Ali, Hashim, Braga, Luca, Gorgodze, Nikoloz, Bernini, Fabio, Burchielli, Silvia, Collesi, Chiara, Zandonà, Lorenzo, Sinagra, Gianfranco, Piacenti, Marcello, Zacchigna, Serena, Bussani, Rossana, Recchia, Fabio A., Giacca, Mauro

“…Prompt coronary catheterization and revascularization have markedly improved the outcomes of myocardial infarction, but have also resulted in a growing number…”
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Persistence of viral RNA, pneumocyte syncytia and thrombosis are hallmarks of advanced COVID-19 pathology by Bussani, Rossana, Schneider, Edoardo, Zentilin, Lorena, Collesi, Chiara, Ali, Hashim, Braga, Luca, Volpe, Maria Concetta, Colliva, Andrea, Zanconati, Fabrizio, Berlot, Giorgio, Silvestri, Furio, Zacchigna, Serena, Giacca, Mauro

“…COVID-19 is a deadly pulmonary disease with peculiar characteristics, which include variable clinical course and thrombophilia. A thorough understanding of the…”
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Paracrine effect of regulatory T cells promotes cardiomyocyte proliferation during pregnancy and after myocardial infarction by Zacchigna, Serena, Martinelli, Valentina, Moimas, Silvia, Colliva, Andrea, Anzini, Marco, Nordio, Andrea, Costa, Alessia, Rehman, Michael, Vodret, Simone, Pierro, Cristina, Colussi, Giulia, Zentilin, Lorena, Gutierrez, Maria Ines, Dirkx, Ellen, Long, Carlin, Sinagra, Gianfranco, Klatzmann, David, Giacca, Mauro

“…Cardiomyocyte proliferation stops at birth when the heart is no longer exposed to maternal blood and, likewise, to regulatory T cells (Tregs) that are expanded…”
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A mouse model for adult cardiac-specific gene deletion with CRISPR/Cas9 by Carroll, Kelli J., Makarewich, Catherine A., McAnally, John, Anderson, Douglas M., Zentilin, Lorena, Liu, Ning, Giacca, Mauro, Bassel-Duby, Rhonda, Olson, Eric N.

“…Clustered regularly interspaced short palindromic repeats (CRISPR)-associated (Cas)9 genomic editing has revolutionized the generation of mutant animals by…”
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Notch1 signaling stimulates proliferation of immature cardiomyocytes by Collesi, Chiara, Zentilin, Lorena, Sinagra, Gianfranco, Giacca, Mauro

“…The identification of the molecular mechanisms controlling cardiomyocyte proliferation during the embryonic, fetal, and early neonatal life appears of…”
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MiR-378 Controls Cardiac Hypertrophy by Combined Repression of Mitogen-Activated Protein Kinase Pathway Factors by Ganesan, Jayavarshni, Ramanujam, Deepak, Sassi, Yassine, Ahles, Andrea, Jentzsch, Claudia, Werfel, Stanislas, Leierseder, Simon, Loyer, Xavier, Giacca, Mauro, Zentilin, Lorena, Thum, Thomas, Laggerbauer, Bernhard, Engelhardt, Stefan

“…BACKGROUND—Several microRNAs (miRs) have been shown to regulate gene expression in the heart, and dysregulation of their expression has been linked to cardiac…”
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Semaphorin 3A overcomes cancer hypoxia and metastatic dissemination induced by antiangiogenic treatment in mice by Maione, Federica, Capano, Stefania, Regano, Donatella, Zentilin, Lorena, Giacca, Mauro, Casanovas, Oriol, Bussolino, Federico, Serini, Guido, Giraudo, Enrico

“…Cancer development, progression, and metastasis are highly dependent on angiogenesis. The use of antiangiogenic drugs has been proposed as a novel strategy to…”
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Genome-wide RNAi screening identifies host restriction factors critical for in vivo AAV transduction by Mano, Miguel, Ippodrino, Rudy, Zentilin, Lorena, Zacchigna, Serena, Giacca, Mauro

“…Viral vectors based on the adeno-associated virus (AAV) hold great promise for in vivo gene transfer; several unknowns, however, still limit the vectors’…”
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Carbon Nanotubes Promote Growth and Spontaneous Electrical Activity in Cultured Cardiac Myocytes by Martinelli, Valentina, Cellot, Giada, Toma, Francesca Maria, Long, Carlin S, Caldwell, John H, Zentilin, Lorena, Giacca, Mauro, Turco, Antonio, Prato, Maurizio, Ballerini, Laura, Mestroni, Luisa

“…Nanoscale manipulations of the extracellular microenvironment are increasingly attracting attention in tissue engineering. Here, combining microscopy,…”
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Common Regulatory Pathways Mediate Activity of MicroRNAs Inducing Cardiomyocyte Proliferation by Torrini, Consuelo, Cubero, Ryan John, Dirkx, Ellen, Braga, Luca, Ali, Hashim, Prosdocimo, Giulia, Gutierrez, Maria Ines, Collesi, Chiara, Licastro, Danilo, Zentilin, Lorena, Mano, Miguel, Zacchigna, Serena, Vendruscolo, Michele, Marsili, Matteo, Samal, Areejit, Giacca, Mauro

“…Loss of functional cardiomyocytes is a major determinant of heart failure after myocardial infarction. Previous high throughput screening studies have…”
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SREBP2 gene therapy targeting striatal astrocytes ameliorates Huntington's disease phenotypes by Birolini, Giulia, Verlengia, Gianluca, Talpo, Francesca, Maniezzi, Claudia, Zentilin, Lorena, Giacca, Mauro, Conforti, Paola, Cordiglieri, Chiara, Caccia, Claudio, Leoni, Valerio, Taroni, Franco, Biella, Gerardo, Simonato, Michele, Cattaneo, Elena, Valenza, Marta

“…Brain cholesterol is produced mainly by astrocytes and is important for neuronal function. Its biosynthesis is severely reduced in mouse models of Huntington's…”
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AAV9-mediated functional screening for cardioprotective cytokines in Coxsackievirus-B3-induced myocarditis by Carai, Paolo, Ruozi, Giulia, Paye, Alexandra, Debing, Yannick, Bortolotti, Francesca, Lecomte, Julie, Zentilin, Lorena, Jones, Elizabeth A. V., Giacca, Mauro, Heymans, Stephane

“…Viral myocarditis (VM) is an important cause of heart failure (HF) in children and adults. However, the molecular determinants involved in cardiac inflammation…”
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Postnatal Cardiac Gene-Editing Using CRISPR/Cas9 with AAV9-Mediated Delivery of Short Guide RNAs Results in Mosaic Gene Disruption by Johansen, Anne Katrine, Molenaar, Bas, Versteeg, Danielle, Leitoguinho, Ana Rita, Demkes, Charlotte, Spanjaard, Bastiaan, de Ruiter, Hesther, Moqadam, Farhad Akbari, Kooijman, Lieneke, Zentilin, Lorena, Giacca, Mauro, van Rooij, Eva

“…RATIONALE:CRISPR/Cas9-based DNA editing has rapidly evolved as an attractive tool to modify the genome. Although CRISPR/Cas9 has been extensively used to…”
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The Mitochondrial Calcium Uniporter Controls Skeletal Muscle Trophism In Vivo by Mammucari, Cristina, Gherardi, Gaia, Zamparo, Ilaria, Raffaello, Anna, Boncompagni, Simona, Chemello, Francesco, Cagnin, Stefano, Braga, Alessandra, Zanin, Sofia, Pallafacchina, Giorgia, Zentilin, Lorena, Sandri, Marco, De Stefani, Diego, Protasi, Feliciano, Lanfranchi, Gerolamo, Rizzuto, Rosario

“…Muscle atrophy contributes to the poor prognosis of many pathophysiological conditions, but pharmacological therapies are still limited. Muscle activity leads…”
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VSV-G-Enveloped Vesicles for Traceless Delivery of CRISPR-Cas9 by Montagna, Claudia, Petris, Gianluca, Casini, Antonio, Maule, Giulia, Franceschini, Gian Marco, Zanella, Ilaria, Conti, Luciano, Arnoldi, Francesca, Burrone, Oscar R., Zentilin, Lorena, Zacchigna, Serena, Giacca, Mauro, Cereseto, Anna

“…The method of delivery of CRISPR-Cas9 into target cells is a strong determinant of efficacy and specificity in genome editing. Even though high efficiency of…”
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Genetic lineage tracing reveals poor angiogenic potential of cardiac endothelial cells by Kocijan, Tea, Rehman, Michael, Colliva, Andrea, Groppa, Elena, Leban, Matteo, Vodret, Simone, Volf, Nina, Zucca, Gabriele, Cappelletto, Ambra, Piperno, Giulia Maria, Zentilin, Lorena, Giacca, Mauro, Benvenuti, Federica, Zhou, Bin, Adams, Ralf H, Zacchigna, Serena

“…Abstract Aims Cardiac ischaemia does not elicit an efficient angiogenic response. Indeed, lack of surgical revascularization upon myocardial infarction results…”
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A new laser device for ultra-rapid and sustainable aerosol sterilization by Vuerich, Roman, Martinelli, Valentina, Vodret, Simone, Bertani, Iris, Carletti, Tea, Zentilin, Lorena, Venturi, Vittorio, Marcello, Alessandro, Zacchigna, Serena

“…The current COVID-19 pandemic has highlighted the relevance of aerosol-based infections. This work describes a laser device able to rapidly sterilize aerosol…”
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Carbon Nanotubes Instruct Physiological Growth and Functionally Mature Syncytia: Nongenetic Engineering of Cardiac Myocytes by Martinelli, Valentina, Cellot, Giada, Toma, Francesca Maria, Long, Carlin S, Caldwell, John H, Zentilin, Lorena, Giacca, Mauro, Turco, Antonio, Prato, Maurizio, Ballerini, Laura, Mestroni, Luisa

“…Myocardial tissue engineering currently represents one of the most realistic strategies for cardiac repair. We have recently discovered the ability of carbon…”
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SARS-CoV-2, myocardial injury and inflammation: insights from a large clinical and autopsy study by Dal Ferro, Matteo, Bussani, Rossana, Paldino, Alessia, Nuzzi, Vincenzo, Collesi, Chiara, Zentilin, Lorena, Schneider, Edoardo, Correa, Ricardo, Silvestri, Furio, Zacchigna, Serena, Giacca, Mauro, Metra, Marco, Merlo, Marco, Sinagra, Gianfranco

“…Objective Despite growing evidence about myocardial injury in hospitalized COronaVIrus Disease 2019 (COVID-19) patients, the mechanism behind this injury is…”
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