Search Results - "Zenka, Roman M"

Clarifying immunoglobulin gene usage in systemic and localized immunoglobulin light-chain amyloidosis by mass spectrometry by Kourelis, Taxiarchis V., Dasari, Surendra, Theis, Jason D., Ramirez-Alvarado, Marina, Kurtin, Paul J., Gertz, Morie A., Zeldenrust, Steven R., Zenka, Roman M., Dogan, Ahmet, Dispenzieri, Angela

“…The goal of this study was to investigate the frequency of use of light-chain variable region (IGVL) genes among patients with systemic (ALS) and localized…”
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Identification of Biomarkers for PKD1 Using Urinary Exosomes by Hogan, Marie C, Bakeberg, Jason L, Gainullin, Vladimir G, Irazabal, Maria V, Harmon, Amber J, Lieske, John C, Charlesworth, M Cristine, Johnson, Kenneth L, Madden, Benjamin J, Zenka, Roman M, McCormick, Daniel J, Sundsbak, Jamie L, Heyer, Christina M, Torres, Vicente E, Harris, Peter C, Ward, Christopher J

“…Autosomal dominant polycystic kidney disease (ADPKD) is a common cause of ESRD. Affected individuals inherit a defective copy of either PKD1 or PKD2, which…”
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Proteomic Detection of Immunoglobulin Light Chain Variable Region Peptides from Amyloidosis Patient Biopsies by Dasari, Surendra, Theis, Jason D, Vrana, Julie A, Meureta, Oana M, Quint, Patrick S, Muppa, Prasuna, Zenka, Roman M, Tschumper, Renee C, Jelinek, Diane F, Davila, Jaime I, Sarangi, Vivekananda, Kurtin, Paul J, Dogan, Ahmet

“…Immunoglobulin light chain (LC) amyloidosis (AL) is caused by deposition of clonal LCs produced by an underlying plasma cell neoplasm. The clonotypic LC…”
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Relative Quantification: Characterization of Bias, Variability and Fold Changes in Mass Spectrometry Data from iTRAQ-Labeled Peptides by Mahoney, Douglas W, Therneau, Terry M, Heppelmann, Carrie J, Higgins, LeeAnn, Benson, Linda M, Zenka, Roman M, Jagtap, Pratik, Nelsestuen, Gary L, Bergen, H. Robert, Oberg, Ann L

“…Shotgun proteomics via mass spectrometry (MS) is a powerful technology for biomarker discovery that has the potential to lead to noninvasive disease screening…”
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Diversity of post-translational modifications and cell signaling revealed by single cell and single organelle mass spectrometry by Mun, Dong-Gi, Bhat, Firdous A., Joshi, Neha, Sandoval, Leticia, Ding, Husheng, Jain, Anu, Peterson, Jane A., Kang, Taewook, Pujari, Ganesh P., Tomlinson, Jennifer L., Budhraja, Rohit, Zenka, Roman M., Kannan, Nagarajan, Kipp, Benjamin R., Dasari, Surendra, Gaspar-Maia, Alexandre, Smoot, Rory L., Kandasamy, Richard K., Pandey, Akhilesh

“…The rapid evolution of mass spectrometry-based single-cell proteomics now enables the cataloging of several thousand proteins from single cells. We…”
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Four‐dimensional proteomics analysis of human cerebrospinal fluid with trapped ion mobility spectrometry using PASEF by Mun, Dong‐Gi, Budhraja, Rohit, Bhat, Firdous A., Zenka, Roman M., Johnson, Kenneth L., Moghekar, Abhay, Pandey, Akhilesh

“…A quadrupole time‐of‐flight mass spectrometer coupled with a trapped ion mobility spectrometry (timsTOF) operated in parallel accumulation‐serial fragmentation…”
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Exploration of Nitrotyrosine-Containing Proteins and Peptides by Antibody-Based Enrichment Strategies by Bhat, Firdous A., Mangalaparthi, Kiran K., Ding, Husheng, Jain, Anu, Hsu, Joel-Sean, Peterson, Jane A., Zenka, Roman M., Mun, Dong-Gi, Kandasamy, Richard K., Pandey, Akhilesh

“…Nitrotyrosine, or 3-nitrotyrosine, is an oxidative post-translational modification induced by reactive nitrogen species. Although nitrotyrosine is considered a…”
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TRIT1 defect leads to a recognizable phenotype of myoclonic epilepsy, speech delay, strabismus, progressive spasticity, and normal lactate levels by Muylle, Ewout, Jiang, Huafang, Johnsen, Christin, Byeon, Seul Kee, Ranatunga, Wasantha, Garapati, Kishore, Zenka, Roman M., Preston, Graeme, Pandey, Akhilesh, Kozicz, Tamas, Fang, Fang, Morava, Eva

“…TRIT1 defect is a rare, autosomal‐recessive disorder of transcription, initially described as a condition with developmental delay, myoclonic seizures, and…”
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Copy number variant analysis using genome‐wide mate‐pair sequencing by Smadbeck, James B., Johnson, Sarah H., Smoley, Stephanie A., Gaitatzes, Athanasios, Drucker, Travis M., Zenka, Roman M., Kosari, Farhad, Murphy, Stephen J., Hoppman, Nicole, Aypar, Umut, Sukov, William R., Jenkins, Robert B., Kearney, Hutton M., Feldman, Andrew L., Vasmatzis, George

“…Copy number variation (CNV) is a common form of structural variation detected in human genomes, occurring as both constitutional and somatic events…”
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Subfractionation, characterization, and in-depth proteomic analysis of glomerular membrane vesicles in human urine by Hogan, Marie C, Johnson, Kenneth L, Zenka, Roman M, Charlesworth, M Cristine, Madden, Benjamin J, Mahoney, Doug W, Oberg, Ann L, Huang, Bing Q, Leontovich, Alexey A, Nesbitt, Lisa L, Bakeberg, Jason L, McCormick, Daniel J, Bergen, H Robert, Ward, Christopher J

“…Urinary exosome-like vesicles (ELVs) are a heterogenous mixture (diameter 40-200 nm) containing vesicles shed from all segments of the nephron including…”
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Development of a multiomics model for identification of predictive biomarkers for COVID-19 severity: a retrospective cohort study by Byeon, Seul Kee, Madugundu, Anil K, Garapati, Kishore, Ramarajan, Madan Gopal, Saraswat, Mayank, Kumar-M, Praveen, Hughes, Travis, Shah, Rameen, Patnaik, Mrinal M, Chia, Nicholas, Ashrafzadeh-Kian, Susan, Yao, Joseph D, Pritt, Bobbi S, Cattaneo, Roberto, Salama, Mohamed E, Zenka, Roman M, Kipp, Benjamin R, Grebe, Stefan K G, Singh, Ravinder J, Sadighi Akha, Amir A, Algeciras-Schimnich, Alicia, Dasari, Surendra, Olson, Janet E, Walsh, Jesse R, Venkatakrishnan, A J, Jenkinson, Garrett, O'Horo, John C, Badley, Andrew D, Pandey, Akhilesh

“…COVID-19 is a multi-system disorder with high variability in clinical outcomes among patients who are admitted to hospital. Although some cytokines such as…”
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SVAtools for junction detection of genome-wide chromosomal rearrangements by mate-pair sequencing (MPseq) by Johnson, Sarah H., Smadbeck, James B., Smoley, Stephanie A., Gaitatzes, Athanasios, Murphy, Stephen J., Harris, Faye R., Drucker, Travis M., Zenka, Roman M., Pitel, Beth A., Rowsey, Ross A., Hoppman, Nicole L., Aypar, Umut, Sukov, William R., Jenkins, Robert B., Feldman, Andrew L., Kearney, Hutton M., Vasmatzis, George

“…•Comparison of junctions reported by mate-pair sequencing with SVAtools, karyotype, FISH and CMA.•Breakpoint resolution by mate-pair sequencing using SVAtools…”
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Mate pair sequencing improves detection of genomic abnormalities in acute myeloid leukemia by Aypar, Umut, Smoley, Stephanie A., Pitel, Beth A., Pearce, Kathryn E., Zenka, Roman M., Vasmatzis, George, Johnson, Sarah H., Smadbeck, James B., Peterson, Jess F., Geiersbach, Katherine B., Van Dyke, Daniel L., Thorland, Erik C., Jenkins, Robert B., Ketterling, Rhett P., Greipp, Patricia T., Kearney, Hutton M., Hoppman, Nicole L., Baughn, Linda B.

“…Objective Acute myeloid leukemia (AML) can be subtyped based on recurrent cytogenetic and molecular genetic abnormalities with diagnostic and prognostic…”
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Clinical Proteome Informatics Workbench Detects Pathogenic Mutations in Hereditary Amyloidoses by Dasari, Surendra, Theis, Jason D, Vrana, Julie A, Zenka, Roman M, Zimmermann, Michael T, Kocher, Jean-Pierre A, Highsmith, W. Edward, Kurtin, Paul J, Dogan, Ahmet

“…Shotgun proteomics of hereditary amyloid deposits generates all the information necessary to identify pathogenic mutant peptides and proteins. However, these…”
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Serum Proteomics on the Basis of Discovery of Predictive Biomarkers of Response to Androgen Deprivation Therapy in Advanced Prostate Cancer by Kohli, Manish, Oberg, Ann L., Mahoney, Douglas W., Riska, Shaun M., Sherwood, Robert, Zhang, Yuzi, Zenka, Roman M., Sahasrabudhe, Deepak, Qin, Rui, Zhang, Sheng

“…We investigated the serum proteome of hormone-sensitive prostate cancer patients to determine candidate biomarkers associated with androgen deprivation therapy…”
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C opy number variant analysis using genome‐wide mate‐pair sequencing by Smadbeck, James B., Johnson, Sarah H., Smoley, Stephanie A., Gaitatzes, Athanasios, Drucker, Travis M., Zenka, Roman M., Kosari, Farhad, Murphy, Stephen J., Hoppman, Nicole, Aypar, Umut, Sukov, William R., Jenkins, Robert B., Kearney, Hutton M., Feldman, Andrew L., Vasmatzis, George

“…Abstract Copy number variation (CNV) is a common form of structural variation detected in human genomes, occurring as both constitutional and somatic events…”
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Serum Proteomics Based Discovery Of Predictive Biomarkers Of Response To Androgen Deprivation Therapy In Advanced Prostate Cancer by Kohli, Manish, Oberg, Ann L., Mahoney, Douglas W., Riska, Shaun M., Sherwood, Robert, Zhang, Yuzi, Zenka, Roman M., Sahasrabudhe, Deepak, Qin, Rui, Zhang, Sheng

“…A global serum proteomic analysis was analyzed using liquid chromatography coupled with tandem mass spectrometry to identify predictive biomarkers in hormone…”
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Cover Image by Aypar, Umut, Smoley, Stephanie A., Pitel, Beth A., Pearce, Kathryn E., Zenka, Roman M., Vasmatzis, George, Johnson, Sarah H., Smadbeck, James B., Peterson, Jess F., Geiersbach, Katherine B., Van Dyke, Daniel L., Thorland, Erik C., Jenkins, Robert B., Ketterling, Rhett P., Greipp, Patricia T., Kearney, Hutton M., Hoppman, Nicole L., Baughn, Linda B.

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Serum proteomics guided discovery of predictive biomarkers of response to androgen ablation (AA) in prostate cancer by Kohli, Manish, Oberg, Ann L., Mahoney, Douglas W., Riska, Shaun M, Zenka, Roman M, Sahasrabudhe, Deepak M., Zhang, Sheng

“…Abstract only 104 Background: Currently there are no serum predictive markers of response to AA. We used a proteomic based analytic approach to identify…”
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Serum proteomics and ingenuity pathway analysis (IPA)-guided discovery of response markers to androgen ablation (AA) in prostate cancer by Kohli, Manish, Oberg, Ann L., Mahoney, Douglas W., Riska, Shaun M, Zhang, Yuji, Zenka, Roman M., Sahasrabudhe, Deepak M., Qin, Rui, Carlson, Rachel, Zhang, Sheng

“…Abstract only 11 Background: Currently there are no serum markers of response to AA. We performed a proteome based analysis of serum from prostate cancer…”
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