Search Results - "Zenitsky, Gary"

Manganese-Induced Neurotoxicity: New Insights Into the Triad of Protein Misfolding, Mitochondrial Impairment, and Neuroinflammation by Harischandra, Dilshan S, Ghaisas, Shivani, Zenitsky, Gary, Jin, Huajun, Kanthasamy, Arthi, Anantharam, Vellareddy, Kanthasamy, Anumantha G

“…Occupational or environmental exposure to manganese (Mn) can lead to the development of "Manganism," a neurological condition showing certain motor symptoms…”
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Impact of Environmental Risk Factors on Mitochondrial Dysfunction, Neuroinflammation, Protein Misfolding, and Oxidative Stress in the Etiopathogenesis of Parkinson's Disease by Huang, Minhong, Bargues-Carot, Alejandra, Riaz, Zainab, Wickham, Hannah, Zenitsky, Gary, Jin, Huajun, Anantharam, Vellareddy, Kanthasamy, Arthi, Kanthasamy, Anumantha G

“…As a prevalent progressive neurodegenerative disorder, Parkinson's disease (PD) is characterized by the neuropathological hallmark of the loss of nigrostriatal…”
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Nuclear pore and nucleocytoplasmic transport impairment in oxidative stress-induced neurodegeneration: relevance to molecular mechanisms in Pathogenesis of Parkinson’s and other related neurodegenerative diseases by Riaz, Zainab, Richardson, Gabriel S., Jin, Huajun, Zenitsky, Gary, Anantharam, Vellareddy, Kanthasamy, Arthi, Kanthasamy, Anumantha G.

“…Nuclear pore complexes (NPCs) are embedded in the nuclear envelope and facilitate the exchange of macromolecules between the nucleus and cytoplasm in…”
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Mechanistic Insights Into Gut Microbiome Dysbiosis-Mediated Neuroimmune Dysregulation and Protein Misfolding and Clearance in the Pathogenesis of Chronic Neurodegenerative Disorders by Padhi, Piyush, Worth, Carter, Zenitsky, Gary, Jin, Huajun, Sambamurti, Kumar, Anantharam, Vellareddy, Kanthasamy, Arthi, Kanthasamy, Anumantha G

“…The human gut microbiota is a complex, dynamic, and highly diverse community of microorganisms. Beginning as early as fetal development and continuing through…”
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PKC Delta Activation Promotes Endoplasmic Reticulum Stress (ERS) and NLR Family Pyrin Domain-Containing 3 (NLRP3) Inflammasome Activation Subsequent to Asynuclein-Induced Microglial Activation: Involvement of Thioredoxin-Interacting Protein (TXNIP)/Thioredoxin (Trx) Redoxisome Pathway by Samidurai, Manikandan, Palanisamy, Bharathi N, Bargues-Carot, Alejandra, Hepker, Monica, Kondru, Naveen, Manne, Sireesha, Zenitsky, Gary, Jin, Huajun, Anantharam, Vellareddy, Kanthasamy, Anumantha G, Kanthasamy, Arthi

“…A classical hallmark of Parkinson's disease (PD) pathogenesis is the accumulation of misfolded alpha-synuclein (αSyn) within Lewy bodies and Lewy neurites,…”
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Mitochondrial dysfunction-induced H3K27 hyperacetylation perturbs enhancers in Parkinson's disease by Huang, Minhong, Lou, Dan, Charli, Adhithiya, Kong, Dehui, Jin, Huajun, Zenitsky, Gary, Anantharam, Vellareddy, Kanthasamy, Arthi, Wang, Zhibin, Kanthasamy, Anumantha G

“…Mitochondrial dysfunction is a major pathophysiological contributor to the progression of Parkinson's disease (PD); however, whether it contributes to…”
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Blocking glutamate-mediated inferior olivary signals abolishes expression of conditioned eyeblinks but does not prevent their acquisition by Carrel, Andrew J, Zenitsky, Gary D, Bracha, Vlastislav

“…The inferior olive (IO) is considered a crucial component of the eyeblink conditioning network. The cerebellar learning hypothesis proposes that the IO…”
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Epitranscriptomic reader YTHDF2 regulates SEK1(MAP2K4)-JNK-cJUN inflammatory signaling in astrocytes during neurotoxic stress by Malovic, Emir, Ealy, Alyssa, Miller, Cameron, Jang, Ahyoung, Hsu, Phillip J., Sarkar, Souvarish, Rokad, Dharmin, Goeser, Cody, Hartman, Aleah Kristen, Zhu, Allen, Palanisamy, Bharathi, Zenitsky, Gary, Jin, Huajun, Anantharam, Vellareddy, Kanthasamy, Arthi, He, Chuan, Kanthasamy, Anumantha G.

“…As the most abundant glial cells in the central nervous system (CNS), astrocytes dynamically respond to neurotoxic stress, however, the key molecular…”
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Tumor Necrosis Factor-Like Weak Inducer of Apoptosis (TWEAK) Enhances Activation of STAT3/NLRC4 Inflammasome Signaling Axis through PKCδ in Astrocytes: Implications for Parkinson's Disease by Samidurai, Manikandan, Tarale, Prashant, Janarthanam, Chelva, Estrada, Crystal Gomez, Gordon, Richard, Zenitsky, Gary, Jin, Huajun, Anantharam, Vellareddy, Kanthasamy, Anumantha G, Kanthasamy, Arthi

“…Astrocytic dysfunction has been implicated in Parkinson's disease (PD) pathogenesis. While the Tumor necrosis factor-like weak inducer of apoptosis…”
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A trigeminal conditioned stimulus yields fast acquisition of cerebellum-dependent conditioned eyeblinks by Carrel, Andrew J., Zbarska, Svitlana, Zenitsky, Gary D., Bracha, Vlastislav

“…► Eyeblink conditioning in rabbits is slow when using traditional auditory stimuli. ► We found that more natural trigeminal vibrissal stimulation yields faster…”
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Inactivation of the brachium conjunctivum prevents extinction of classically conditioned eyeblinks by Nilaweera, Wijitha U., Zenitsky, Gary D., Bracha, Vlastislav

“…It is well established that the intermediate cerebellum is involved in the acquisition of classically conditioned eyeblink responses (CRs). Recent studies that…”
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Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein by Harischandra, Dilshan S, Rokad, Dharmin, Neal, Matthew L, Ghaisas, Shivani, Manne, Sireesha, Sarkar, Souvarish, Panicker, Nikhil, Zenitsky, Gary, Jin, Huajun, Lewis, Mechelle, Huang, Xuemei, Anantharam, Vellareddy, Kanthasamy, Arthi, Kanthasamy, Anumantha G

“…The aggregation of α-synuclein (αSyn) is considered a key pathophysiological feature of certain neurodegenerative disorders, collectively termed…”
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Manganese exposure induces neuroinflammation by impairing mitochondrial dynamics in astrocytes by Sarkar, Souvarish, Malovic, Emir, Harischandra, Dilshan S., Ngwa, Hilary A., Ghosh, Anamitra, Hogan, Colleen, Rokad, Dharmin, Zenitsky, Gary, Jin, Huajun, Anantharam, Vellareddy, Kanthasamy, Anumantha G., Kanthasamy, Arthi

“…•Mn induces mitochondrial dysfunction in astrocytes.•Mn exposure induces inflammatory response in astrocytes and exacerbates αSynagg-induced inflammatory…”
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Environmental neurotoxic pesticide exposure induces gut inflammation and enteric neuronal degeneration by impairing enteric glial mitochondrial function in pesticide models of Parkinson’s disease: Potential relevance to gut-brain axis inflammation in Parkinson’s disease pathogenesis by Palanisamy, Bharathi N., Sarkar, Souvarish, Malovic, Emir, Samidurai, Manikandan, Charli, Adhithiya, Zenitsky, Gary, Jin, Huajun, Anantharam, Vellareddy, Kanthasamy, Arthi, Kanthasamy, Anumantha G.

“…Despite the growing recognition that gastrointestinal (GI) dysfunction is prevalent in Parkinson's disease (PD) and occurs as a major prodromal symptom of PD,…”
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Emerging Microbiome Genetic Engineering Technology for Stable Levodopa Delivery in Parkinson’s Disease by Padhi, Piyush, Abdalla, Ahmed, Backes, Nick, Zenitsky, Gary, Jin, Huajun, Anantharam, Vellareddy, Kanthasamy, Arthi, Phillips, Gregory, Kanthasamy, Anumantha

“…Dopamine replacement in the form of a levodopa/carbidopa tablet has been the gold‐standard therapy for Parkinson’s disease (PD) for over six decades. Oral…”
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Emerging Microbiome Genetic Engineering Technology for Stable Levodopa Delivery in Parkinson’s Disease by Padhi, Piyush, Abdalla, Ahmed, Backes, Nicholas, Wurtz, Joseph, Zenitsky, Gary, Jin, Huajun, Anantharam, Vellareddy, Kanthasamy, Arthi, Phillips, Gregory, Kanthasamy, Anumantha

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Environmental Neurotoxic Pesticide Exposure Induces Gut Inflammation and Enteric Neuronal Degeneration by Impairing Enteric Glial Mitochondrial Function in Pesticide Models of Parkinson’s Disease: Potential Relevance to Gut-Brain Axis Inflammation in Disease Pathogenesis by Palanisamy, Bharathi N, Sarkar, Souvarish, Malovic, Emir, Samidurai, Manikandan, Charli, Adhithiya, Zenitsky, Gary, Jin, Huajun, Anantharam, Vellareddy, Kanthasamy, Arthi, Kanthasamy, Anumantha

“…Despite the growing recognition that gastrointestinal (GI) dysfunction is prevalent in Parkinson’s disease (PD) and occurs as a major prodromal symptom of PD,…”
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Chronic Manganese Exposure and the Enteric Nervous System: An in Vitro and Mouse in Vivo Study by Ghaisas, Shivani, Harischandra, Dilshan S, Palanisamy, Bharathi, Proctor, Alexandra, Jin, Huajun, Dutta, Somak, Sarkar, Souvarish, Langley, Monica, Zenitsky, Gary, Anantharam, Vellareddy, Kanthasamy, Arthi, Phillips, Gregory J, Kanthasamy, Anumantha

“…Chronic environmental exposure to manganese (Mn) can cause debilitating damage to the central nervous system. However, its potential toxic effects on the…”
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Manganese Exposure Enhances the Release of Misfolded α-Synuclein via Exosomes by Impairing Endosomal Trafficking and Protein Degradation Mechanisms by Rokad, Dharmin, Harischandra, Dilshan S., Samidurai, Manikandan, Chang, Yuan-Teng, Luo, Jie, Lawana, Vivek, Sarkar, Souvarish, Palanisamy, Bharathi N., Manne, Sireesha, Kim, Dongsuk, Zenitsky, Gary, Jin, Huajun, Anantharam, Vellareddy, Willette, Auriel, Kanthasamy, Arthi, Kanthasamy, Anumantha G.

“…Excessive exposure to manganese (Mn) increases the risk of chronic neurological diseases, including Parkinson’s disease (PD) and other related Parkinsonisms…”
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Lasting Retinal Injury in a Mouse Model of Blast-Induced Trauma by Mammadova, Najiba, Ghaisas, Shivani, Zenitsky, Gary, Sakaguchi, Donald S, Kanthasamy, Anumantha G, Greenlee, Justin J, West Greenlee, M. Heather

“…Traumatic brain injury due to blast exposure is currently the most prevalent of war injuries. Although secondary ocular blast injuries due to flying debris are…”
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