Antiproliferative activity of Pt(IV) complexes with lonidamine and bexarotene ligands attached via succinate-ethylenediamine linker

[Display omitted] •The new Pt(IV) complexes with lonidamine and bexarotene ligand tethered to Pt-center via a succinate-ethylenediamine linker were prepared.•The in vitro results indicate that incorporating the lonidamine or bexarotene moiety can confer activity and selectivity of Pt(IV) complexes.•...

Full description

Saved in:

Bibliographic Details
Published in:	Inorganica Chimica Acta Vol. 495; p. 119010
Main Authors:	Okulova, Y.N., Zenin, I.V., Shutkov, I.A., Kirsanov, K.I., Kovaleva, O.N., Lesovaya, E.A., Fetisov, T.I., Milaeva, E.R., Nazarov, A.A
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier B.V 01-09-2019 Elsevier Science Ltd
Subjects:	Antiproliferatives Dichlorides Ethane Ethylenediamine Ligands Platinum Selectivity
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	[Display omitted] •The new Pt(IV) complexes with lonidamine and bexarotene ligand tethered to Pt-center via a succinate-ethylenediamine linker were prepared.•The in vitro results indicate that incorporating the lonidamine or bexarotene moiety can confer activity and selectivity of Pt(IV) complexes.•The coordination sphere was confirmed by 195Pt NMR spectroscopy. We present the synthesis and cytotoxic potencies of new Pt(IV) complexes with lonidamine and bexarotene ligand tethered to Pt-center via a succinate-ethylenediamine linker. The in vitro results for a series of complexes with cisplatin, dichloride(ethane-1,2-diamine)platinum(II), or oxaliplatin core indicate that the addition to the structure lonidamine or bexarotene moiety can confer activity or selectivity of Pt(IV) complexes.
ISSN:	0020-1693 1873-3255
DOI:	10.1016/j.ica.2019.119010