Search Results - "Zengeler, Kristine E."

Innate immunity at the crossroads of healthy brain maturation and neurodevelopmental disorders by Zengeler, Kristine E., Lukens, John R.

“…The immune and nervous systems have unique developmental trajectories that individually build intricate networks of cells with highly specialized functions…”
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SYK coordinates neuroprotective microglial responses in neurodegenerative disease by Ennerfelt, Hannah, Frost, Elizabeth L., Shapiro, Daniel A., Holliday, Coco, Zengeler, Kristine E., Voithofer, Gabrielle, Bolte, Ashley C., Lammert, Catherine R., Kulas, Joshua A., Ulland, Tyler K., Lukens, John R.

“…Recent studies have begun to reveal critical roles for the brain’s professional phagocytes, microglia, and their receptors in the control of neurotoxic amyloid…”
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CARD9 attenuates Aβ pathology and modifies microglial responses in an Alzheimer's disease mouse model by Ennerfelt, Hannah, Holliday, Coco, Shapiro, Daniel A, Zengeler, Kristine E, Bolte, Ashley C, Ulland, Tyler K, Lukens, John R

“…Recent advances have highlighted the importance of several innate immune receptors expressed by microglia in Alzheimer's disease (AD). In particular, mounting…”
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Microglia pack a toolbox for life by Zengeler, Kristine E., Lukens, John R.

“…Core homeostatic and activation signatures have been defined for mammalian microglia in new transcriptomic and functional studies.Microglia respond to changes…”
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Misguided antibodies change the course of brain development by Zengeler, Kristine E., Lukens, John R.

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Taking the parkin brakes off of neuronal NLRP3 drives inflammasome activation and neurodegeneration in Parkinson’s disease by Zengeler, Kristine E., Lukens, John R.

“…NLRP3 is a central driver of neurodegeneration thought to function mainly in microglia. In this issue of Neuron, Panicker et al. (2022) find that NLRP3 is a…”
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Deciphering the Enigma of the Histone H2A.Z-1/H2A.Z-2 Isoforms: Novel Insights and Remaining Questions by Cheema, Manjinder S, Good, Katrina V, Kim, Bohyun, Soufari, Heddy, O'Sullivan, Connor, Freeman, Melissa E, Stefanelli, Gilda, Casas, Ciro Rivera, Zengeler, Kristine E, Kennedy, Andrew J, Eirin Lopez, Jose Maria, Howard, Perry L, Zovkic, Iva B, Shabanowitz, Jeffrey, Dryhurst, Deanna D, Hunt, Donald F, Mackereth, Cameron D, Ausió, Juan

“…The replication independent (RI) histone H2A.Z is one of the more extensively studied variant members of the core histone H2A family, which consists of many…”
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Maternal inflammation is hard for offspring to stomach by Zengeler, Kristine E., Lukens, John R.

“…Individuals with neurodevelopmental disorders often experience comorbid gastrointestinal distress and dysregulated immune responses, yet the underlying…”
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Inflammation stresses out brain development by Zengeler, Kristine E., Lukens, John R.

“…A new study reveals that maternal immune activation promotes sex-biased activation of the integrated stress response in the developing mouse brain and that…”
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SSRI treatment modifies the effects of maternal inflammation on in utero physiology and offspring neurobiology by Zengeler, Kristine E., Shapiro, Daniel A., Bruch, Katherine R., Lammert, Catherine R., Ennerfelt, Hannah, Lukens, John R.

“…•Maternal immune activation (MIA) elicits an inflammatory transcriptional response at the maternal-fetal interface (MFI).•Baseline sex differences in the MFI…”
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