Search Results - "Zeng, Xiao‐Yi"

Repurposing Drugs to Target the Diabetes Epidemic by Turner, Nigel, Zeng, Xiao-Yi, Osborne, Brenna, Rogers, Suzanne, Ye, Ji-Ming

“…Despite major investment by pharmaceutical companies in conventional drug discovery pipelines, development of new drugs has failed to keep up with the…”
Get full text

Restoration of Autophagy Alleviates Hepatic ER Stress and Impaired Insulin Signalling Transduction in High Fructose-Fed Male Mice by Wang, Hao, Sun, Ruo-Qiong, Zeng, Xiao-Yi, Zhou, Xiu, Li, Songpei, Jo, Eunjung, Molero, Juan C, Ye, Ji-Ming

“…High-carbohydrate (mainly fructose) consumption is a major dietary factor for hepatic insulin resistance, involving endoplasmic reticulum (ER) stress and lipid…”
Get full text

Differing endoplasmic reticulum stress response to excess lipogenesis versus lipid oversupply in relation to hepatic steatosis and insulin resistance by Ren, Lu-Ping, Chan, Stanley M H, Zeng, Xiao-Yi, Laybutt, D Ross, Iseli, Tristan J, Sun, Ruo-Qiong, Kraegen, Edward W, Cooney, Gregory J, Turner, Nigel, Ye, Ji-Ming

“…Mitochondrial dysfunction and endoplasmic reticulum (ER) stress have been implicated in hepatic steatosis and insulin resistance. The present study…”
Get full text

Identification of matrine as a promising novel drug for hepatic steatosis and glucose intolerance with HSP72 as an upstream target by Zeng, Xiao‐Yi, Wang, Hao, Bai, Fang, Zhou, Xiu, Li, Song‐Pei, Ren, Lu‐Ping, Sun, Ruo‐Qiong, Xue, Charlie C L, Jiang, Hua‐Liang, Hu, Li‐Hong, Ye, Ji‐Ming

“…Background and Purpose Matrine is a small molecule drug used in humans for the treatment of chronic viral infections and tumours in the liver with little…”
Get full text

Activation of AMPK by bitter melon triterpenoids involves CaMKKβ by Iseli, Tristan J, Turner, Nigel, Zeng, Xiao-Yi, Cooney, Gregory J, Kraegen, Edward W, Yao, Sheng, Ye, Yang, James, David E, Ye, Ji-Ming

“…We recently showed that bitter melon-derived triterpenoids (BMTs) activate AMPK and increase GLUT4 translocation to the plasma membrane in vitro, and improve…”
Get full text

Endoplasmic reticulum stress up‐regulates Nedd4‐2 to induce autophagy by Wang, Hao, Sun, Ruo‐Qiong, Camera, Daria, Zeng, Xiao‐Yi, Jo, Eunjung, Chan, Stanley M. H., Herbert, Terence P., Molero, Juan C., Ye, Ji‐Ming

“…ABSTRACT The accumulation of unfolded proteins within the endoplasmic reticulum (ER) causes ER stress and activation of unfolded protein response (UPR). This…”
Get full text

Oleanolic acid reduces hyperglycemia beyond treatment period with Akt/FoxO1-induced suppression of hepatic gluconeogenesis in type-2 diabetic mice by Zeng, Xiao-Yi, Wang, Yi-Ping, Cantley, James, Iseli, Tristan J, Molero, Juan Carlos, Hegarty, Bronwyn D, Kraegen, Edward W, Ye, Yang, Ye, Ji-Ming

“…The present study investigated the chronic efficacy of oleanolic acid (OA), a triterpenoid selected from our recent screening, on hyperglycemia in type-2…”
Get full text

Repurposing matrine for the treatment of hepatosteatosis and associated disorders in glucose homeostasis in mice by Mahzari, Ali, Zeng, Xiao-Yi, Zhou, Xiu, Li, Songpei, Xu, Jun, Tan, Wen, Vlahos, Ross, Robinson, Stephen, YE, Ji-Ming

“…The present study investigated the efficacy of the hepatoprotective drug matrine (Mtr) for its new application for hepatosteatosis and associated disorders in…”
Get full text

Characterization of the Therapeutic Profile of Albiflorin for the Metabolic Syndrome by Zhou, Xiu, Fouda, Sherouk, Zeng, Xiao-Yi, Li, Dongli, Zhang, Kun, Xu, Jun, Ye, Ji-Ming

“…Albiflorin (AF) is a small molecule (MW 481) isolated from Paeoniae radix , a plant used as a remedy for various conditions with pathogenesis shared by…”
Get full text

Hepatic FoxO1 acetylation is involved in oleanolic acid-induced memory of glycemic control: novel findings from Study 2 by Zhou, Xiu, Zeng, Xiao-Yi, Wang, Hao, Li, Songpei, Jo, Eunjung, Xue, Charlie C L, Tan, Minjia, Molero, Juan C, Ye, Ji-Ming

“…Our recent study (referred as Study 1) showed that the triterpenoid oleanolic acid (OA) was able to produce a sustained correction of hyperglycemia beyond…”
Get full text

Dietary cholesterol induces hepatic inflammation and blunts mitochondrial function in the liver of high-fat-fed mice by Li, Songpei, Zeng, Xiao-Yi, Zhou, Xiu, Wang, Hao, Jo, Eunjung, Robinson, Stephen R., Xu, Aimin, Ye, Ji-Ming

“…The present study investigated the role of dietary cholesterol and fat in the development of nonalcoholic fatty liver disease, a common liver disease in…”
Get full text

A gas trapping method for high-throughput metabolic experiments by Krycer, James R, Diskin, Ciana, Nelson, Marin E, Zeng, Xiao-Yi, Fazakerley, Daniel J, James, David E

“…Research into cellular metabolism has become more high-throughput, with typical cell-culture experiments being performed in multiwell plates (microplates)…”
Get full text

Fenofibrate insulates diacylglycerol in lipid droplet/ER and preserves insulin signaling transduction in the liver of high fat fed mice by Chan, Stanley M.H., Zeng, Xiao-Yi, Sun, Ruo-Qiong, Jo, Eunjung, Zhou, Xiu, Wang, Hao, Li, Songpei, Xu, Aimin, Watt, Matthew J., Ye, Ji-Ming

“…Hepatic steatosis is often associated with insulin resistance as a hallmark of the metabolic syndrome in the liver. The present study investigated the effects…”
Get full text

PPARδ agonists have opposing effects on insulin resistance in high fat‐fed rats and mice due to different metabolic responses in muscle by Ye, Ji‐Ming, Tid‐Ang, Jennifer, Turner, Nigel, Zeng, Xiao‐Yi, Li, Hai‐Yan, Cooney, Gregory J., Wulff, Erik Max, Sauerberg, Per, Kraegen, Edward W.

“…BACKGROUND AND PURPOSE The peroxisome proliferator‐activated receptor (PPAR)δ has been considered a therapeutic target for diabetes and obesity through…”
Get full text

Psychometric Evaluation of the Chinese Version of the Claremont Purpose Scale among Youth by Wang, Tong, Ye, Yu Qiao, Zeng, Xiao Yi

“…Purpose in life is critical to positive development among youth, especially those purposes that focus on an aspect of the world beyond the self. However,…”
Get full text

Activation of PPARα Ameliorates Hepatic Insulin Resistance and Steatosis in High Fructose-Fed Mice Despite Increased Endoplasmic Reticulum Stress by CHAN, Stanley M. H, SUN, Ruo-Qiong, ZENG, Xiao-Yi, CHOONG, Zi-Heng, HAO WANG, WATT, Matthew J, YE, Ji-Ming

“…Endoplasmic reticulum (ER) stress is suggested to cause hepatic insulin resistance by increasing de novo lipogenesis (DNL) and directly interfering with…”
Get full text

Establishing subdivisions of M1 stage nasopharyngeal carcinoma based on decision tree classification: A multicenter retrospective study by Liu, Yang, Zuo, Zhi-Chao, Zeng, Xiao-Yi, Ma, Jie, Ma, Cheng-Xian, Chen, Rui-Zhong, Liang, Zhong-Guo, Chen, Kai-Hua, Li, Ling, Qu, Song, Lu, Jie-Yan, Zhu, Xiao-Dong

“…•We aimed to establish an M1 subdivision for personalized prognosis prediction and treatment planning for mNPC.•M1 subdivision demonstrated superior…”
Get full text

Efficacy of metastatic lesion radiotherapy in patients with metastatic nasopharyngeal carcinoma: A multicenter retrospective study by Liu, Yang, Ma, Jie, Zeng, Xiao-Yi, Zuo, Zhi-Chao, Chen, Rui-Zhong, Li, Xiao-Yu, Liang, Zhong-Guo, Chen, Kai-Hua, Pan, Xin-Bin, Pei, Su, Yu, Bin-Bin, Li, Ling, Qu, Song, Yang, Yun-Li, Zhu, Xiao-Dong

“…•Contradictory results have been reported for the potential survival benefit of radiation therapy for metastases.•We investigated the efficacy of metastatic…”
Get full text

Liver glycogen in type 2 diabetic mice is randomly branched as enlarged aggregates with blunted glucose release by Besford, Quinn Alexander, Zeng, Xiao-Yi, Ye, Ji-Ming, Gray-Weale, Angus

“…Glycogen is a vital highly branched polymer of glucose that is essential for blood glucose homeostasis. In this article, the structure of liver glycogen from…”
Get full text

Metabolomic analysis of insulin resistance across different mouse strains and diets by Stöckli, Jacqueline, Fisher-Wellman, Kelsey H., Chaudhuri, Rima, Zeng, Xiao-Yi, Fazakerley, Daniel J., Meoli, Christopher C., Thomas, Kristen C., Hoffman, Nolan J., Mangiafico, Salvatore P., Xirouchaki, Chrysovalantou E., Yang, Chieh-Hsin, Ilkayeva, Olga, Wong, Kari, Cooney, Gregory J., Andrikopoulos, Sofianos, Muoio, Deborah M., James, David E.

“…Insulin resistance is a major risk factor for many diseases. However, its underlying mechanism remains unclear in part because it is triggered by a complex…”
Get full text