Search Results - "Zeng, Qiru"

TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes by Zang, Ruochen, Gomez Castro, Maria Florencia, McCune, Broc T, Zeng, Qiru, Rothlauf, Paul W, Sonnek, Naomi M, Liu, Zhuoming, Brulois, Kevin F, Wang, Xin, Greenberg, Harry B, Diamond, Michael S, Ciorba, Matthew A, Whelan, Sean P J, Ding, Siyuan

“…Gastrointestinal symptoms and fecal shedding of SARS-CoV-2 RNA are frequently observed in COVID-19 patients. However, it is unclear whether SARS-CoV-2…”
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Neutralizing Antibody and Soluble ACE2 Inhibition of a Replication-Competent VSV-SARS-CoV-2 and a Clinical Isolate of SARS-CoV-2 by Case, James Brett, Rothlauf, Paul W., Chen, Rita E., Liu, Zhuoming, Zhao, Haiyan, Kim, Arthur S., Bloyet, Louis-Marie, Zeng, Qiru, Tahan, Stephen, Droit, Lindsay, Ilagan, Ma. Xenia G., Tartell, Michael A., Amarasinghe, Gaya, Henderson, Jeffrey P., Miersch, Shane, Ustav, Mart, Sidhu, Sachdev, Virgin, Herbert W., Wang, David, Ding, Siyuan, Corti, Davide, Theel, Elitza S., Fremont, Daved H., Diamond, Michael S., Whelan, Sean P.J.

“…Antibody-based interventions against SARS-CoV-2 could limit morbidity, mortality, and possibly transmission. An anticipated correlate of such countermeasures…”
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Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion by Zang, Ruochen, Case, James Brett, Yutuc, Eylan, Ma, Xiucui, Shen, Sheng, Castro, Maria Florencia Gomez, Liu, Zhuoming, Zeng, Qiru, Zhao, Haiyan, Son, Juhee, Rothlauf, Paul W., Kreutzberger, Alex J. B., Hou, Gaopeng, Zhang, Hu, Bose, Sayantan, Wang, Xin, Vahey, Michael D., Mani, Kartik, Griffiths, William J., Kirchhausen, Tom, Fremont, Daved H., Guo, Haitao, Diwan, Abhinav, Wang, Yuqin, Diamond, Michael S., Whelan, Sean P. J., Ding, Siyuan

“…Cholesterol 25-hydroxylase (CH25H) is an interferon (IFN)-stimulated gene that shows broad antiviral activities against a wide range of enveloped viruses…”
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CMPK2 is a host restriction factor that inhibits infection of multiple coronaviruses in a cell-intrinsic manner by Zhu, Mingjun, Lv, Jiahuang, Wang, Wei, Guo, Rongli, Zhong, Chunyan, Antia, Avan, Zeng, Qiru, Li, Jizong, Liu, Qingtao, Zhou, Jinzhu, Zhu, Xuejiao, Fan, Baochao, Ding, Siyuan, Li, Bin

“…Coronaviruses (CoVs) comprise a group of important human and animal pathogens. Despite extensive research in the past 3 years, the host innate immune defense…”
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Rotavirus NSP1 Contributes to Intestinal Viral Replication, Pathogenesis, and Transmission by Hou, Gaopeng, Zeng, Qiru, Matthijnssens, Jelle, Greenberg, Harry B, Ding, Siyuan

“…Rotavirus (RV)-encoded nonstructural protein 1 (NSP1), the product of gene segment 5, effectively antagonizes host interferon (IFN) signaling via multiple…”
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Calpain-2 mediates SARS-CoV-2 entry via regulating ACE2 levels by Zeng, Qiru, Antia, Avan, Casorla-Perez, Luis Alberto, Puray-Chavez, Maritza, Kutluay, Sebla B, Ciorba, Matthew A, Ding, Siyuan

“…Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic, much effort has been dedicated to identifying effective antivirals against severe…”
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SARS-CoV-2 Omicron BA.1 Variant Infection of Human Colon Epithelial Cells by Antia, Avan, Alvarado, David M, Zeng, Qiru, Casorla-Perez, Luis A, Davis, Deanna L, Sonnek, Naomi M, Ciorba, Matthew A, Ding, Siyuan

“…The Omicron variant of SARS-CoV-2, characterized by multiple subvariants including BA.1, XBB.1.5, EG.5, and JN.1, became the predominant strain in early 2022…”
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Targeting the Fusion Process of SARS-CoV-2 Infection by Small Molecule Inhibitors by Park, Seung Bum, Irvin, Parker, Hu, Zongyi, Khan, Mohsin, Hu, Xin, Zeng, Qiru, Chen, Catherine, Xu, Miao, Leek, Madeleine, Zang, Ruochen, Case, James Brett, Zheng, Wei, Ding, Siyuan, Liang, T Jake

“…Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a serious threat to global public…”
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JIB-04 Has Broad-Spectrum Antiviral Activity and Inhibits SARS-CoV-2 Replication and Coronavirus Pathogenesis by Son, Juhee, Huang, Shimeng, Zeng, Qiru, Bricker, Traci L, Case, James Brett, Zhou, Jinzhu, Zang, Ruochen, Liu, Zhuoming, Chang, Xinjian, Darling, Tamarand L, Xu, Jian, Harastani, Houda H, Chen, Lu, Gomez Castro, Maria Florencia, Zhao, Yongxiang, Kohio, Hinissan P, Hou, Gaopeng, Fan, Baochao, Niu, Beibei, Guo, Rongli, Rothlauf, Paul W, Bailey, Adam L, Wang, Xin, Shi, Pei-Yong, Martinez, Elisabeth D, Brody, Steven L, Whelan, Sean P J, Diamond, Michael S, Boon, Adrianus C M, Li, Bin, Ding, Siyuan

“…Pathogenic coronaviruses are a major threat to global public health. Here, using a recombinant reporter virus-based compound screening approach, we identified…”
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Rhesus rotavirus NSP1 mediates extra-intestinal infection and is a contributing factor for biliary obstruction by Li, Enkai, Feng, Ningguo, Zeng, Qiru, Sanchez-Tacuba, Liliana, Kawagishi, Takahiro, Branham, Grace, Hou, Gaopeng, Wang, Zemin, Greenberg, Harry B, Ding, Siyuan

“…We previously demonstrated that in Ifnar1-/-Ifngr1-/- or Stat1-/- suckling mice lacking intact type I and type II interferon (IFN) signaling, rhesus rotavirus…”
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