Search Results - "Zeng, David L."

Antibody structure, instability, and formulation by Wang, Wei, Singh, Satish, Zeng, David L, King, Kevin, Nema, Sandeep

“…The number of therapeutic monoclonal antibody in development has increased tremendously over the last several years and this trend continues. At present there…”
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Ultrasonic rheology of a monoclonal antibody (IgG2) solution: implications for physical stability of proteins in high concentration formulations by Saluja, Atul, Badkar, Advait V, Zeng, David L, Kalonia, Devendra S

“…The purpose of this work was to investigate if physical stability of a model monoclonal antibody (IgG(2)), as determined by extent of aggregation, was related…”
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Application of high-frequency rheology measurements for analyzing protein-protein interactions in high protein concentration solutions using a model monoclonal antibody (IgG2) by Saluja, Atul, Badkar, Advait V, Zeng, David L, Nema, Sandeep, Kalonia, Devendra S

“…The purpose of this work was to explore the utilization of high-frequency rheology analysis for assessing protein-protein interactions in high protein…”
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Application of maximum bubble pressure surface tensiometer to study protein–surfactant interactions by Dixit, Nitin, Zeng, David L., Kalonia, Devendra S.

“…Binding of a surfactant to proteins can affect their physicochemical stability and solubility in a formulation. The extent of the effect depends on the binding…”
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Ultrasonic Storage Modulus as a Novel Parameter for Analyzing Protein-Protein Interactions in High Protein Concentration Solutions: Correlation with Static and Dynamic Light Scattering Measurements by Saluja, Atul, Badkar, Advait V., Zeng, David L., Nema, Sandeep, Kalonia, Devendra S.

“…The purpose of this work was to establish ultrasonic storage modulus ( G′) as a novel parameter for characterizing protein-protein interactions (PPI) in high…”
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Retrospective statistical analysis of lyophilized protein formulations of progenipoietin using PLS: determination of the critical parameters for long-term storage stability by Katayama, Derrick S, Kirchhoff, Carol F, Elliott, Carrie M, Johnson, Robert E, Borgmeyer, Jeffry, Thiele, Barrett R, Zeng, David L, Qi, Hong, Ludwig, John D, Manning, Mark C

“…Although certain criteria have become recognized as being essential for a stable lyophilized formulation, the relative importance of different stability…”
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Purification and characterization of progenipoietins produced in Escherichia. coli by Violand, Bernard N, Minnerly, John C, Feng, Yiqing G, Polazzi, Joseph O, Mathis, Karl J, Thomas, Kristin E, Zeng, David L

“…The progenipoietins (ProGPs) are a family of genetically engineered chimeric proteins that contain receptor agonist activity for both fetal liver tyrosine…”
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Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer by Kang, Rui, Xie, Yangchun, Zhang, Qiuhong, Hou, Wen, Jiang, Qingping, Zhu, Shan, Liu, Jinbao, Zeng, Dexing, Wang, Haichao, Bartlett, David L, Billiar, Timothy R, Zeh, Herbert J, Lotze, Michael T, Tang, Daolin

“…Pancreatic ductal adenocarcinoma （PDAC） driven by oncogenic K-Ras remains among the most lethal human cancers despite recent advances in modern medicine. The…”
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Use of combinatorial mutagenesis to select for multiply substituted human interleukin-3 variants with improved pharmacologic properties by Klein, Barbara K., Olins, Peter O., Bauer, S.Christopher, Caparon, Maire H., Easton, Alan M., Braford, Sarah R., Abrams, Mark A., Klover, Jon A., Paik, Kumnan, Thomas, John W., Hood, William F., Shieh, Jeng-Jong, Polazzi, Joseph O., Donnelly, Ann M., Zeng, David L., Welply, Joseph K., McKearn, John P.

“…A combinatorial mutagenesis strategy was used to create a collection of nearly 500 variants of human interleukin 3 (IL-3), each with four to nine amino acid…”
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