Search Results - "Zemskov, Evgeny A."

Complex interplay between autophagy and oxidative stress in the development of pulmonary disease by Ornatowski, Wojciech, Lu, Qing, Yegambaram, Manivannan, Garcia, Alejandro E., Zemskov, Evgeny A., Maltepe, Emin, Fineman, Jeffrey R., Wang, Ting, Black, Stephen M.

“…The autophagic pathway involves the encapsulation of substrates in double-membraned vesicles, which are subsequently delivered to the lysosome for enzymatic…”
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The mitochondrial redistribution of eNOS is involved in lipopolysaccharide induced inflammasome activation during acute lung injury by Wang, Hui, Sun, Xutong, Lu, Qing, Zemskov, Evgeny A., Yegambaram, Manivannan, Wu, Xiaomin, Wang, Ting, Tang, Haiyang, Black, Stephen M.

“…Acute lung injury (ALI) is a devastating clinical syndrome with no effective therapies. Inflammasome activation has been reported to play a critical role in…”
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Unconventional secretion of tissue transglutaminase involves phospholipid-dependent delivery into recycling endosomes by Zemskov, Evgeny A, Mikhailenko, Irina, Hsia, Ru-Ching, Zaritskaya, Liubov, Belkin, Alexey M

“…Although endosomal compartments have been suggested to play a role in unconventional protein secretion, there is scarce experimental evidence for such…”
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NF-κB-dependent repression of Sox18 transcription factor requires the epigenetic regulators histone deacetylases 1 and 2 in acute lung injury by Zemskov, Evgeny A, Gross, Christine M, Aggarwal, Saurabh, Zemskova, Marina A, Wu, Xiaomin, Gu, Chenxin, Wang, Ting, Tang, Haiyang, Black, Stephen M

“…In acute lung injury (ALI), the NF-κB-mediated downregulation of Sox18 gene expression leads to the disruption of the pulmonary endothelial barrier. Previous…”
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The Pulmonary Endothelial Glycocalyx Modifications in Glypican 1 Knockout Mice Do Not Affect Lung Endothelial Function in Physiological Conditions by Thota, Lakshmi N R, Lopez Rosales, Joaquin E, Placencia, Ivan, Zemskov, Evgeny A, Tonino, Paola, Michael, Ashley N, Black, Stephen M, Chignalia, Andreia Z

“…The endothelial glycocalyx is a dynamic signaling surface layer that is involved in the maintenance of cellular homeostasis. The glycocalyx has a very diverse…”
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The role of tissue transglutaminase in cell-matrix interactions by Zemskov, Evgeny A, Janiak, Anna, Hang, Jun, Waghray, Anu, Belkin, Alexey M

“…Numerous studies over the last two decades revealed a complexity and multiple functions of tissue transglutaminase (tTG or TG2, EC 2.3.2.13). Besides the…”
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Loss of SOX18/CLAUDIN5 disrupts the pulmonary endothelial barrier in ventilator-induced lung injury by Garcia-Flores, Alejandro E, Gross, Christine M, Zemskov, Evgeny A, Lu, Qing, Tieu, Kim, Wang, Ting, Black, Stephen M

“…Mechanical strain contributes to ventilator-induced lung injury (VILI) through multi-factorial and complex mechanisms that remain unresolved. Prevailing…”
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Activation of the mechanosensitive Ca2+ channel TRPV4 induces endothelial barrier permeability via the disruption of mitochondrial bioenergetics by Lu, Qing, Zemskov, Evgeny A., Sun, Xutong, Wang, Hui, Yegambaram, Manivannan, Wu, Xiaomin, Garcia-Flores, Alejandro, Song, Shanshan, Tang, Haiyang, Kangath, Archana, Cabanillas, Gabriela Zubiate, Yuan, Jason X.-J., Wang, Ting, Fineman, Jeffrey R., Black, Stephen M.

“…Mechanical ventilation is a life-saving intervention in critically ill patients with respiratory failure due to acute respiratory distress syndrome (ARDS), a…”
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The leading role of microtubules in endothelial barrier dysfunction: Disassembly of peripheral microtubules leaves behind the cytoskeletal reorganization by Alieva, Irina B., Zemskov, Evgeny A., Smurova, Ksenija M., Kaverina, Irina N., Verin, Alexander D.

“…Disturbance of the endothelial barrier is characterized by dramatic cytoskeleton reorganization, activation of actomyosin contraction and, finally, leads to…”
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Agonist of growth hormone-releasing hormone reduces pneumolysin-induced pulmonary permeability edema by Lucas, Rudolf, Sridhar, Supriya, Rick, Ferenc G, Gorshkov, Boris, Umapathy, Nagavedi S, Yang, Guang, Oseghale, Aluya, Verin, Alexander D, Chakraborty, Trinad, Matthay, Michael A, Zemskov, Evgeny A, White, Richard, Block, Norman L, Schally, Andrew V

“…Aggressive treatment with antibiotics in patients infected with Streptococcus pneumoniae induces release of the bacterial virulence factor pneumolysin (PLY)…”
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Cell surface transglutaminase promotes RhoA activation via integrin clustering and suppression of the Src-p190RhoGAP signaling pathway by Janiak, Anna, Zemskov, Evgeny A, Belkin, Alexey M

“…Tissue transglutaminase (tTG) is a multifunctional protein that serves as cross-linking enzyme and integrin-binding adhesion coreceptor for fibronectin on the…”
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Regulation of Platelet-derived Growth Factor Receptor Function by Integrin-associated Cell Surface Transglutaminase by Zemskov, Evgeny A., Loukinova, Elena, Mikhailenko, Irina, Coleman, Richard A., Strickland, Dudley K., Belkin, Alexey M.

“…A functional collaboration between growth factor receptors such as platelet derived growth factor receptor (PDGFR) and integrins is required for effective…”
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Cell-surface transglutaminase undergoes internalization and lysosomal degradation: an essential role for LRP1 by Zemskov, Evgeny A, Mikhailenko, Irina, Strickland, Dudley K, Belkin, Alexey M

“…Tissue transglutaminase functions as a protein crosslinking enzyme and an integrin-binding adhesion co-receptor for fibronectin on the cell surface. These…”
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Arginase 1: an unexpected mediator of pulmonary capillary barrier dysfunction in models of acute lung injury by Lucas, Rudolf, Czikora, Istvàn, Sridhar, Supriya, Zemskov, Evgeny A, Oseghale, Aluya, Circo, Sebastian, Cederbaum, Stephen D, Chakraborty, Trinad, Fulton, David J, Caldwell, Robert W, Romero, Maritza J

“…The integrity of epithelial and endothelial barriers in the lower airspaces of the lungs has to be tightly regulated, in order to prevent leakage and to assure…”
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Novel mechanism of cyclic nucleotide crosstalk mediated by PKG-dependent proteasomal degradation of the Hsp90 client protein phosphodiesterase 3A by Zemskov, Evgeny A., Zemskova, Marina A., Wu, Xiaomin, Moreno Caceres, Santiago, Caraballo Delgado, David, Yegambaram, Manivannan, Lu, Qing, Fu, Panfeng, Wang, Ting, Black, Stephen M.

“…Endothelial cAMP-specific phosphodiesterase PDE3A is one of the major negative regulators of the endothelial barrier function in acute lung injury models…”
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Nitration of protein kinase G-Iα modulates cyclic nucleotide crosstalk via phosphodiesterase 3A: Implications for acute lung injury by Zemskov, Evgeny A., Wu, Xiaomin, Aggarwal, Saurabh, Yegambaram, Mannivannan, Gross, Christine, Lu, Qing, Wang, Hui, Tang, Haiyang, Wang, Ting, Black, Stephen M.

“…Phosphodiesterase 3A (PDE3A) selectively cleaves the phosphodiester bond of cAMP and is inhibited by cGMP, making it an important regulator of cAMP–cGMP…”
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Nitration-mediated activation of the small GTPase RhoA stimulates cellular glycolysis through enhanced mitochondrial fission by Lu, Qing, Sun, Xutong, Yegambaram, Manivannan, Ornatowski, Wojciech, Wu, Xiaomin, Wang, Hui, Garcia-Flores, Alejandro, Da Silva, Victoria, Zemskov, Evgeny A., Tang, Haiyang, Fineman, Jeffrey R., Tieu, Kim, Wang, Ting, Black, Stephen M.

“…Mitochondrial fission and a Warburg phenotype of increased cellular glycolysis are involved in the pathogenesis of pulmonary hypertension (PH). The purpose of…”
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Biomechanical Forces and Oxidative Stress: Implications for Pulmonary Vascular Disease by Zemskov, Evgeny A, Lu, Qing, Ornatowski, Wojciech, Klinger, Christina N, Desai, Ankit A, Maltepe, Emin, Yuan, Jason X-J, Wang, Ting, Fineman, Jeffrey R, Black, Stephen M

“…Oxidative stress in the cell is characterized by excessive generation of reactive oxygen species (ROS). Superoxide (O ) and hydrogen peroxide (H O ) are the…”
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LPS-induced Acute Lung Injury Involves NF-κB-mediated Downregulation of SOX18 by Gross, Christine M, Kellner, Manuela, Wang, Ting, Lu, Qing, Sun, Xutong, Zemskov, Evgeny A, Noonepalle, Satish, Kangath, Archana, Kumar, Sanjiv, Gonzalez-Garay, Manuel, Desai, Ankit A, Aggarwal, Saurabh, Gorshkov, Boris, Klinger, Christina, Verin, Alexander D, Catravas, John D, Jacobson, Jeffrey R, Yuan, Jason X-J, Rafikov, Ruslan, Garcia, Joe G N, Black, Stephen M

“…One of the early events in the progression of LPS-mediated acute lung injury in mice is the disruption of the pulmonary endothelial barrier resulting in lung…”
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Protective effect of adenosine receptors against lipopolysaccharide-induced acute lung injury by Gonzales, Joyce N, Gorshkov, Boris, Varn, Matthew N, Zemskova, Marina A, Zemskov, Evgeny A, Sridhar, Supriya, Lucas, Rudolf, Verin, Alexander D

“…Acute lung injury and acute respiratory distress syndrome (ALI/ARDS) affect 200,000 people a year in the USA. Pulmonary vascular and specifically endothelial…”
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