Search Results - "Zemlan, Frank P"

Early intervention with a small molecule inhibitor for tumor nefosis factor-α prevents cognitive deficits in a triple transgenic mouse model of Alzheimer’s disease by Gabbita, S Prasad, Srivastava, Minu K, Eslami, Pirooz, Johnson, Ming F, Kobritz, Naomi K, Tweedie, David, Greig, Nigel H, Zemlan, Frank P, Sharma, Sherven P, Harris-White, Marni E

“…Abstract Background Chronic neuroinflammation is an important component of Alzheimer’s disease and could contribute to neuronal dysfunction, injury and loss…”
Get full text

Serum cleaved tau does not predict postconcussion syndrome after mild traumatic brain injury by Ma, Marek, MD, Lindsell, Christopher J., PhD, Rosenberry, Clark M., BS, Shaw, George J., MD, PhD, Zemlan, Frank P., PhD

“…Abstract Objectives Our objective was to determine if the biomarker for axonal injury, serum cleaved tau (C-tau), predicts postconcussion syndrome (PCS) in…”
Get full text

A selective dopamine reuptake inhibitor improves prefrontal cortex-dependent cognitive function: Potential relevance to attention deficit hyperactivity disorder by Schmeichel, Brooke E., Zemlan, Frank P., Berridge, Craig W.

“…Drugs used to treat attention deficit hyperactivity disorder (ADHD) improve prefrontal cortex (PFC)-dependent cognitive function. The majority of ADHD-related…”
Get full text

Hypothermia as an adjunctive treatment for severe bacterial meningitis by Irazuzta, Jose E., Pretzlaff, Robert, Rowin, Mark, Milam, Kevin, Zemlan, Frank P., Zingarelli, Basilia

“…Brain injury due to bacterial meningitis results in a high mortality rate and significant neurologic sequelae in survivors. The objective of this study was to…”
Get full text

Serum S-100B and cleaved-tau are poor predictors of long-term outcome after mild traumatic brain injury by Bazarian, Jeffrey J., Zemlan, Frank P., Mookerjee, Sohug, Stigbrand, Torgney

“…Primary objective: To determine the relationship of serum S-100B and C-tau levels to long-term outcome after mild traumatic brain injury (mild TBI). Research…”
Get full text

Early intervention with a small molecule inhibitor for tumor necrosis factor-α prevents cognitive deficits in a triple transgenic mouse model of Alzheimer's disease by Gabbita, S Prasad, Srivastava, Minu K, Eslami, Pirooz, Johnson, Ming F, Kobritz, Naomi K, Tweedie, David, Greig, Nigel H, Zemlan, Frank P, Sharma, Sherven P, Harris-White, Marni E

“…Chronic neuroinflammation is an important component of Alzheimer's disease and could contribute to neuronal dysfunction, injury and loss that lead to disease…”
Get full text

C-tau biomarker of neuronal damage in severe brain injured patients: association with elevated intracranial pressure and clinical outcome by Zemlan, Frank P, Jauch, Edward C, Mulchahey, J.Jeffery, Gabbita, S.Prasad, Rosenberg, William S, Speciale, Samuel G, Zuccarello, Mario

“…Following traumatic brain injury, the neuronally-localized intracellular protein MAP-tau is proteolytically cleaved (C-tau) and gains access to cerebrospinal…”
Get full text

The efficacy and safety of the melatonin agonist β-methyl-6-chloromelatonin in primary insomnia : A randomized, placebo-controlled, crossover clinical trial by ZEMLAN, Frank P, MULCHAHEY, J. Jeffery, SCHARF, Martin B, MAYLEBEN, David W, ROSENBERG, Russell, LANKFORD, Alan

“…While melatonin agonists are known to regulate circadian sleep rhythms, it is not clear whether melatonin agonists have a direct soporific effect. It has been…”
Get full text

Serum cleaved tau protein levels and clinical outcome in adult patients with closed head injury by Shaw, George J., Jauch, Edward C., Zemlan, Frank P.

“…Study Objective: Intracranial injuries (ICI) are associated with high mortality and morbidity. Unfortunately, tools for diagnosis and risk stratification of…”
Get full text

Serum cleaved Tau protein and neurobehavioral battery of tests as markers of brain injury in experimental bacterial meningitis by Irazuzta, Jose E, de Courten-Myers, Gabrielle, Zemlan, Frank P, Bekkedal, Marni Y.V, Rossi, John

“…Brain injury due to bacterial meningitis affects multiple areas of the brain with a heterogeneous distribution generating a challenge to assess severity. Tau…”
Get full text

Activation of Lordotic Responding in Female Rats by Suppression of Serotonergic Activity by Zemlan, Frank P., Ward, Ingeborg L., Crowley, William R., Margules, D. L.

“…After systemic administration of several serotonergic antagonists, female rats that had been ovariectomized, adrenalectomized, and estrogen-primed showed…”
Get full text

Identification of Microtubule-Associated Protein Tau Isoforms in Alzheimer's Paired Helical Filaments by McLaughlin, Lea, Zemlan, Frank P, Dean, Gary E

“…AD66 proteins derived from sodium dodecylsulfate (SDS) insoluble paired helical filaments (PHF) were isolated from Alzheimer's brain using a purification…”
Get full text

5-HT1A receptors mediate the effect of the bulbospinal serotonin system on spinal dorsal horn nociceptive neurons by Zemlan, F P, Murphy, A Z, Behbehani, M M

“…The present study examined whether the effect of stimulation of the nucleus raphe magnus (NRM) is mediated by spinal cord dorsal horn serotonin1A (5-HT1A)…”
Get more information

Biochemical Assay of Alzheimer's Disease—Associated Protein(s) in Human Brain Tissue: A Clinical Study by Ghanbari, Hossein A, Miller, Barney E, Haigler, Henry J, Arato, Mihaly, Bissette, Garth, Davies, Peter, Nemeroff, Charles B, Perry, Elaine K, Perry, Robert, Ravid, Rivka, Swaab, Dick F, Whetsell, William O, Zemlan, Frank P

“…The concentration of Alzheimer's disease—associated protein (ADAP) was measured in postmortem brain tissue samples of temporal or frontal cortex from 111 human…”
Get full text

Cleaved-tau: a biomarker of neuronal damage after traumatic brain injury by Gabbita, S Prasad, Scheff, Stephen W, Menard, Renee M, Roberts, Kelly, Fugaccia, Isabella, Zemlan, Frank P

“…Previous studies from our laboratory indicate that traumatic brain injury (TBI) in humans results in proteolysis of neuronally-localized, intracellular…”
Get more information

Ascending and descending projections from nucleus reticularis magnocellularis and nucleus reticularis gigantocellularis: an autoradiographic and horseradish peroxidase study in the rat by Zemlan, F P, Behbehani, M M, Beckstead, R M

“…The projections of the rostral medulla were studied using retrograde and orthograde transport techniques in the rat. The present horseradish peroxidase (HRP)…”
Get more information

Quantitative autoradiographic mapping of a novel serotonin receptor-5-HT1S by Murphy, R M, Zemlan, F P

“…The spinal cord distribution of a recently identified, high affinity 3H-5-HT binding site, the 5-HT1S receptor was studied employing quantitative…”
Get more information

Early intervention with a small molecule inhibitor for tumor nefosis factor-[alpha] prevents cognitive deficits in a triple transgenic mouse model of Alzheimer's disease by Gabbita, S Prasad, Srivastava, Minu K, Eslami, Pirooz, Johnson, Ming F, Kobritz, Naomi K, Tweedie, David, Greig, Nigel H, Zemlan, Frank P, Sharma, Sherven P, Harris-White, Marni E

“…Background Chronic neuroinflammation is an important component of Alzheimer's disease and could contribute to neuronal dysfunction, injury and loss that lead…”
Get full text

Quantification of axonal damage in traumatic brain injury : Affinity purification and characterization of cerebrospinal fluid tau proteins by ZEMLAN, F. P, ROSENBERG, W. S, LUEBBE, P. A, CAMPBELL, T. A, DEAN, G. E, WEINER, N. E, COHEN, J. A, RUDICK, R. A, WOO, D

“…Diffuse axonal injury is a primary feature of head trauma and is one of the most frequent causes of mortality and morbidity. Diffuse axonal injury is…”
Get full text

Growth hormone response to apomorphine and diagnosis: a comparison of three diagnostic systems by Hirschowitz, J, Zemlan, F P, Hitzemann, R J, Fleischmann, R L, Garver, D L

“…Our study takes a further look at the apomorphine test in the psychoses and affective disorders, with special reference to the use of different diagnostic…”
Get more information