Search Results - "Zemlan, Frank"

Early intervention with a small molecule inhibitor for tumor nefosis factor-α prevents cognitive deficits in a triple transgenic mouse model of Alzheimer’s disease by Gabbita, S Prasad, Srivastava, Minu K, Eslami, Pirooz, Johnson, Ming F, Kobritz, Naomi K, Tweedie, David, Greig, Nigel H, Zemlan, Frank P, Sharma, Sherven P, Harris-White, Marni E

“…Abstract Background Chronic neuroinflammation is an important component of Alzheimer’s disease and could contribute to neuronal dysfunction, injury and loss…”
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A selective dopamine reuptake inhibitor improves prefrontal cortex-dependent cognitive function: Potential relevance to attention deficit hyperactivity disorder by Schmeichel, Brooke E., Zemlan, Frank P., Berridge, Craig W.

“…Drugs used to treat attention deficit hyperactivity disorder (ADHD) improve prefrontal cortex (PFC)-dependent cognitive function. The majority of ADHD-related…”
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Oral TNFα Modulation Alters Neutrophil Infiltration, Improves Cognition and Diminishes Tau and Amyloid Pathology in the 3xTgAD Mouse Model by Gabbita, S Prasad, Johnson, Ming F, Kobritz, Naomi, Eslami, Pirooz, Poteshkina, Aleksandra, Varadarajan, Sridhar, Turman, John, Zemlan, Frank, Harris-White, Marni E

“…Cytokines such as TNFα can polarize microglia/macrophages into different neuroinflammatory types. Skewing of the phenotype towards a cytotoxic state is thought…”
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Serum S-100B and cleaved-tau are poor predictors of long-term outcome after mild traumatic brain injury by Bazarian, Jeffrey J., Zemlan, Frank P., Mookerjee, Sohug, Stigbrand, Torgney

“…Primary objective: To determine the relationship of serum S-100B and C-tau levels to long-term outcome after mild traumatic brain injury (mild TBI). Research…”
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Serum cleaved tau does not predict postconcussion syndrome after mild traumatic brain injury by Ma, Marek, MD, Lindsell, Christopher J., PhD, Rosenberry, Clark M., BS, Shaw, George J., MD, PhD, Zemlan, Frank P., PhD

“…Abstract Objectives Our objective was to determine if the biomarker for axonal injury, serum cleaved tau (C-tau), predicts postconcussion syndrome (PCS) in…”
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Early intervention with a small molecule inhibitor for tumor necrosis factor-α prevents cognitive deficits in a triple transgenic mouse model of Alzheimer's disease by Gabbita, S Prasad, Srivastava, Minu K, Eslami, Pirooz, Johnson, Ming F, Kobritz, Naomi K, Tweedie, David, Greig, Nigel H, Zemlan, Frank P, Sharma, Sherven P, Harris-White, Marni E

“…Chronic neuroinflammation is an important component of Alzheimer's disease and could contribute to neuronal dysfunction, injury and loss that lead to disease…”
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C-tau biomarker of neuronal damage in severe brain injured patients: association with elevated intracranial pressure and clinical outcome by Zemlan, Frank P, Jauch, Edward C, Mulchahey, J.Jeffery, Gabbita, S.Prasad, Rosenberg, William S, Speciale, Samuel G, Zuccarello, Mario

“…Following traumatic brain injury, the neuronally-localized intracellular protein MAP-tau is proteolytically cleaved (C-tau) and gains access to cerebrospinal…”
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The efficacy and safety of the melatonin agonist β-methyl-6-chloromelatonin in primary insomnia : A randomized, placebo-controlled, crossover clinical trial by ZEMLAN, Frank P, MULCHAHEY, J. Jeffery, SCHARF, Martin B, MAYLEBEN, David W, ROSENBERG, Russell, LANKFORD, Alan

“…While melatonin agonists are known to regulate circadian sleep rhythms, it is not clear whether melatonin agonists have a direct soporific effect. It has been…”
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Serum cleaved tau protein levels and clinical outcome in adult patients with closed head injury by Shaw, George J., Jauch, Edward C., Zemlan, Frank P.

“…Study Objective: Intracranial injuries (ICI) are associated with high mortality and morbidity. Unfortunately, tools for diagnosis and risk stratification of…”
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Quantification of axonal damage in traumatic brain injury : Affinity purification and characterization of cerebrospinal fluid tau proteins by ZEMLAN, F. P, ROSENBERG, W. S, LUEBBE, P. A, CAMPBELL, T. A, DEAN, G. E, WEINER, N. E, COHEN, J. A, RUDICK, R. A, WOO, D

“…Diffuse axonal injury is a primary feature of head trauma and is one of the most frequent causes of mortality and morbidity. Diffuse axonal injury is…”
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Hypothermia as an adjunctive treatment for severe bacterial meningitis by Irazuzta, Jose E., Pretzlaff, Robert, Rowin, Mark, Milam, Kevin, Zemlan, Frank P., Zingarelli, Basilia

“…Brain injury due to bacterial meningitis results in a high mortality rate and significant neurologic sequelae in survivors. The objective of this study was to…”
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Serum cleaved Tau protein and neurobehavioral battery of tests as markers of brain injury in experimental bacterial meningitis by Irazuzta, Jose E, de Courten-Myers, Gabrielle, Zemlan, Frank P, Bekkedal, Marni Y.V, Rossi, John

“…Brain injury due to bacterial meningitis affects multiple areas of the brain with a heterogeneous distribution generating a challenge to assess severity. Tau…”
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Safety, tolerability and pharmacokinetics of 2-pyridylacetic acid, a major metabolite of betahistine, in a phase 1 dose escalation study in subjects with ADHD by Moorthy, Ganesh, Sallee, Floyd, Gabbita, Prasad, Zemlan, Frank, Sallans, Larry, Desai, Pankaj B.

“…Betahistine, a potent histamine H3 receptor antagonist, is being developed for the treatment of attention deficit hyperactivity disorder (ADHD) that manifests…”
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Increased cerebrospinal fluid cleaved tau protein (C-tau) levels suggest axonal damage in pediatric patients with brain tumors by Cengiz, Pelin, Zemlan, Frank, Eickhoff, Jens C., Ellenbogen, Richard, Zimmerman, Jerry J.

“…Objective This study aims to determine if cerebrospinal fluid/serum cleaved tau protein and CSF 9-hydroxyoctadecadienoic acid levels, reflecting potential…”
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Oral TNF[alpha] Modulation Alters Neutrophil Infiltration, Improves Cognition and Diminishes Tau and Amyloid Pathology in the 3xTgAD Mouse Model by Gabbita, S. Prasad, Johnson, Ming F, Kobritz, Naomi, Eslami, Pirooz, Poteshkina, Aleksandra, Varadarajan, Sridhar, Turman, John, Zemlan, Frank, Harris-White, Marni E

“…Cytokines such as TNF[alpha] can polarize microglia/macrophages into different neuroinflammatory types. Skewing of the phenotype towards a cytotoxic state is…”
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Quantification of Axonal Damage in Traumatic Brain Injury by Zemlan, Frank, Rosenberg, William S., Luebbe, Patricia A., Campbell, Thomas A., Dean, Gary E., Weiner, Ned E., Cohen, Jeffery A., Rudick, Richard A., Woo, Daniel

“…: Diffuse axonal injury is a primary feature of head trauma and is one of the most frequent causes of mortality and morbidity. Diffuse axonal injury is…”
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Identification of Microtubule-Associated Protein Tau Isoforms in Alzheimer's Paired Helical Filaments by McLaughlin, Lea, Zemlan, Frank P, Dean, Gary E

“…AD66 proteins derived from sodium dodecylsulfate (SDS) insoluble paired helical filaments (PHF) were isolated from Alzheimer's brain using a purification…”
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Biochemical Assay of Alzheimer's Disease—Associated Protein(s) in Human Brain Tissue: A Clinical Study by Ghanbari, Hossein A, Miller, Barney E, Haigler, Henry J, Arato, Mihaly, Bissette, Garth, Davies, Peter, Nemeroff, Charles B, Perry, Elaine K, Perry, Robert, Ravid, Rivka, Swaab, Dick F, Whetsell, William O, Zemlan, Frank P

“…The concentration of Alzheimer's disease—associated protein (ADAP) was measured in postmortem brain tissue samples of temporal or frontal cortex from 111 human…”
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Cleaved-tau: a biomarker of neuronal damage after traumatic brain injury by Gabbita, S Prasad, Scheff, Stephen W, Menard, Renee M, Roberts, Kelly, Fugaccia, Isabella, Zemlan, Frank P

“…Previous studies from our laboratory indicate that traumatic brain injury (TBI) in humans results in proteolysis of neuronally-localized, intracellular…”
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The arachidonic acid 5‐lipoxygenase inhibitor nordihydroguaiaretic acid inhibits tumor necrosis factor α activation of microglia and extends survival of G93A‐SOD1 transgenic mice by West, Melinda, Mhatre, Molina, Ceballos, Alex, Floyd, Robert A., Grammas, Paula, Gabbita, S. Prasad, Hamdheydari, Ladan, Mai, Tammy, Mou, Shenyun, Pye, Quentin N., Stewart, Charles, West, Stuart, Williamson, Kelly S., Zemlan, Frank, Hensley, Kenneth

“…Familial forms of amyotrophic lateral sclerosis (ALS) can be caused by mutations in copper, zinc‐superoxide dismutase (SOD1). Mice expressing SOD1 mutants…”
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