Search Results - "Zemlan, F P"

The effect of amphetamine analogs on cleaved microtubule-associated protein-tau formation in the rat brain by Straiko, M.M.W, Coolen, L.M, Zemlan, F.P, Gudelsky, G.A

“…Abstract The present study quantified the cleaved form of the microtubule-associated protein tau (cleaved MAP-tau, C-tau), a previously demonstrated marker of…”
Get full text

Quantification of axonal damage in traumatic brain injury : Affinity purification and characterization of cerebrospinal fluid tau proteins by ZEMLAN, F. P, ROSENBERG, W. S, LUEBBE, P. A, CAMPBELL, T. A, DEAN, G. E, WEINER, N. E, COHEN, J. A, RUDICK, R. A, WOO, D

“…Diffuse axonal injury is a primary feature of head trauma and is one of the most frequent causes of mortality and morbidity. Diffuse axonal injury is…”
Get full text

Methamphetamine enhances the cleavage of the cytoskeletal protein tau in the rat brain by Wallace, T.L, Vorhees, C.V, Zemlan, F.P, Gudelsky, G.A

“…The view that methamphetamine is neurotoxic to dopaminergic and serotonergic axon terminals has been based largely on biochemical and histological studies. In…”
Get full text

Quantification and localization of kainic acid-induced neurotoxicity employing a new biomarker of cell death: cleaved microtubule-associated protein-tau (c-tau) by Zemlan, F.P, Mulchahey, J.J, Gudelsky, G.A

“…Previous studies of neuronal degeneration induced by the neurotoxin, kainic acid, employed silver stain techniques that are non-quantitative or ELISA…”
Get full text

Discordant temporal patterns of S100 β and cleaved tau protein elevation after head injury: a pilot study by Chatfield, D. A., Zemlan, F. P., Day, D. J., Menon, D. K.

“…There is considerable interest in S100 g protein as a potential marker that can be used to quantify central nervous system injury. However, increasing…”
Get full text

A single blind, placebo controlled, across groups dose escalation study of the safety, tolerability, pharmacokinetics and pharmacodynamics of the melatonin analog β-methyl-6-chloromelatonin by Mulchahey, J.J, Goldwater, D.R, Zemlan, F.P

“…Clinical investigation of melatonin agonists has been hampered by side effects such as hypothermia, hypotension and bradycardia. The availability of a…”
Get full text

Characterization of N-formyl-methionyl-leucyl-phenylalanine receptors on human neutrophils. Effects of isolation and temperature on receptor expression and functional activity by Tennenberg, SD, Zemlan, FP, Solomkin, JS

“…The study of polymorphonuclear neutrophil (PMN) surface receptor expression provides a means for the assessment of PMN function and state of cellular…”
Get full text

C-tau biomarker of neuronal damage in severe brain injured patients: association with elevated intracranial pressure and clinical outcome by Zemlan, Frank P, Jauch, Edward C, Mulchahey, J.Jeffery, Gabbita, S.Prasad, Rosenberg, William S, Speciale, Samuel G, Zuccarello, Mario

“…Following traumatic brain injury, the neuronally-localized intracellular protein MAP-tau is proteolytically cleaved (C-tau) and gains access to cerebrospinal…”
Get full text

The efficacy and safety of the melatonin agonist β-methyl-6-chloromelatonin in primary insomnia : A randomized, placebo-controlled, crossover clinical trial by ZEMLAN, Frank P, MULCHAHEY, J. Jeffery, SCHARF, Martin B, MAYLEBEN, David W, ROSENBERG, Russell, LANKFORD, Alan

“…While melatonin agonists are known to regulate circadian sleep rhythms, it is not clear whether melatonin agonists have a direct soporific effect. It has been…”
Get full text

Superoxide dismutase activity in Alzheimer's disease: possible mechanism for paired helical filament formation by Zemlan, F P, Thienhaus, O J, Bosmann, H B

“…Activity of the free radical scavenging enzyme, superoxide dismutase (SOD-1), was determined in fibroblast cell lines derived from familial Alzheimer's…”
Get more information

Differential effects of substance P on serotonin-modulated spinal nociceptive reflexes by MURPHY, R. M, ZEMLAN, F. P

“…Recent immunohistochemical studies indicate the presence of a bulbospinal substance P (SP) system, as well as a bulbospinal serotonin (5-HT) system, involved…”
Get full text

Velnacrine for the treatment of Alzheimer's disease : a double-blind, placebo-controlled trial by ZEMLAN, F. P

“…The present study examines the safety and efficacy of the centrally acting cholinesterase inhibitor, velnacrine, in treating the cognitive symptoms of…”
Get full text

Spinal serotonin (5-HT) receptor subtypes and nociception by Zemlan, F P, Kow, L M, Pfaff, D W

Get more information

Treatment with trimethyltin promotes the formation of cleaved tau in the rat brain by Straiko, M.M.W., Gudelsky, G.A., Coolen, L.M., Harrison, R., Zemlan, F.P.

“…Trimethyltin (TMT) is a well‐documented neurotoxin that affects primarily limbic system structures. Most previous studies have relied on histological…”
Get full text

Cerebral aging: a quantitative study of gliosis in old nude mice by MANDYBUR, T. I, ORMSBY, I, ZEMLAN, F. P

“…Morphometric glial fibrillary acidic protein (GFAP) studies of the brains of 11 old (18-29 months) female, outbred athymic mice demonstrated astrocytic gliosis…”
Get full text

Nucleus cuneiformis and pain modulation: anatomy and behavioral pharmacology by Zemlan, F P, Behbehani, M M

“…The anatomical substrate and behavioral pharmacology of stimulation-produced analgesia resulting from electrical stimulation of the pontomesencephalic nucleus…”
Get more information

A new scale for assessing behavioral agitation in dementia by Sinha, D, Zemlan, F P, Nelson, S, Bienenfeld, D, Thienhaus, O, Ramaswamy, G, Hamilton, S

“…The primary purpose of the present study was to develop a reliable and valid rating instrument for assessing treatment efficacy for behavioral problems in the…”
Get more information

Selective 5-HT1B agonists identify the 5-HT autoreceptor in lumbar spinal cord of rat by Murphy, R M, Zemlan, F P

“…The purpose of the present study was to characterize the 5-HT autoreceptor in the lumbar spinal cord of the rat. The effect of selective 5-HT1A and 5-HT1B…”
Get more information

Identification of Microtubule-Associated Protein Tau Isoforms in Alzheimer's Paired Helical Filaments by McLaughlin, Lea, Zemlan, Frank P, Dean, Gary E

“…AD66 proteins derived from sodium dodecylsulfate (SDS) insoluble paired helical filaments (PHF) were isolated from Alzheimer's brain using a purification…”
Get full text

Characterization of a novel serotonin receptor subtype (5-HT1S) in rat CNS: interaction with a GTP binding protein by Zemlan, F P, Schwab, E F

“…Three pharmacologically distinct high-affinity [3H]serotonin ([3H]5-HT) binding sites were identified in spinal cord synaptosomes. [3H]5-HT competition studies…”
Get more information