Search Results - "Zembryki, Denise"

Multicenter Phase II Study of Lapatinib in Patients with Brain Metastases from HER2-Positive Breast Cancer by LIN, Nancy U, DIERAS, Véronique, LOIBL, Sibylle, GORI, Stefania, WARDLEY, Andrew, YARDLEY, Denise, BRUFSKY, Adam, BLUM, Joanne L, RUBIN, Stephen D, DHARAN, Bernie, STEPLEWSKI, Klaudia, ZEMBRYKI, Denise, PAUL, Devchand, OLIVA, Cristina, ROYCHOWDHURY, Debasish, PAOLETTI, Paolo, WINER, Eric P, LOSSIGNOL, Dominique, CHRISTODOULOU, Christos, STEMMLER, Hans-Joachim, ROCHE, Henri, LIU, Minetta C, GREIL, Richard, CIRUELOS, Eva

“…Purpose: Brain metastases develop in one third of patients with advanced HER2+ breast cancer. Effective therapy for patients with central nervous system (CNS)…”
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Structure Activity Relationships of 5-, 6-, and 7-Methyl-Substituted Azepan-3-one Cathepsin K Inhibitors by Yamashita, Dennis S, Marquis, Robert W, Xie, Ren, Nidamarthy, Sirishkumar D, Oh, Hye-Ja, Jeong, Jae U, Erhard, Karl F, Ward, Keith W, Roethke, Theresa J, Smith, Brian R, Cheng, H-Y, Geng, Xiaoliu, Lin, Fan, Offen, Priscilla H, Wang, Bing, Nevins, Neysa, Head, Martha S, Haltiwanger, R. Curtis, Narducci Sarjeant, Amy A, Liable-Sands, Louise M, Zhao, Baoguang, Smith, Ward W, Janson, Cheryl A, Gao, Enoch, Tomaszek, Thaddeus, McQueney, Michael, James, Ian E, Gress, Catherine J, Zembryki, Denise L, Lark, Michael W, Veber, Daniel F

“…The syntheses, in vitro characterizations, and rat and monkey in vivo pharmacokinetic profiles of a series of 5-, 6-, and 7-methyl-substituted azepanone-based…”
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Potent and Selective Cathepsin L Inhibitors Do Not Inhibit Human Osteoclast Resorption in Vitro by James, Ian E., Marquis, Robert W., Blake, Simon M., Hwang, Shing Mei, Gress, Catherine J., Ru, Yu, Zembryki, Denise, Yamashita, Dennis S., McQueney, Michael S., Tomaszek, Thaddeus A., Oh, Hye-Ja, Gowen, Maxine, Veber, Daniel F., Lark, Michael W.

“…Cathepsins K and L are related cysteine proteases that have been proposed to play important roles in osteoclast-mediated bone resorption. To further examine…”
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Randomized phase II study of lapatinib plus capecitabine or lapatinib plus topotecan for patients with HER2-positive breast cancer brain metastases by Lin, Nancy U., Eierman, Wolfgang, Greil, Richard, Campone, Mario, Kaufman, Bella, Steplewski, Klaudia, Lane, Stephen R., Zembryki, Denise, Rubin, Stephen D., Winer, Eric P.

“…Approximately one-third of patients with advanced, HER2-positive breast cancer develop brain metastases. A significant proportion of women experience central…”
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Oral versus intravenous administration of vinorelbine as a single agent for the first-line treatment of metastatic nonsmall cell lung carcinoma (NSCLC): A randomized phase II trial by Hirsh, Vera, Desjardins, Pierre, Needles, Burton M, Rigas, James R, Jahanzeb, Mohammad, Nguyen, Laurent, Zembryki, Denise, Leopold, Lance H

“…Many patients with metastatic nonsmall cell lung carcinoma (NSCLC) cannot tolerate intravenous chemotherapy. Orally active agents would be more convenient and…”
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Design of Potent and Selective Human Cathepsin K Inhibitors that Span the Active Site by Thompson, S K, Halbert, S M, Bossard, M J, Tomaszek, T A, Levy, M A, Zhao, B, Smith, W W, Abdel-Meguid, S S, Janson, C A, D'Alessio, K J, McQueney, M S, Amegadzie, B Y, Hanning, C R, DesJarlais, R L, Briand, J, Sarkar, S K, Huddleston, M J, Ijames, C F, Carr, S A, Garnes, K T, Shu, A, Heys, J R, Bradbeer, J, Zembryki, D, Lee-Rykaczewski, L, James, I E, Lark, M W, Drake, F H, Gowen, M, Gleason, J G, Veber, D F

“…Potent and selective active-site-spanning inhibitors have been designed for cathepsin K, a cysteine protease unique to osteoclasts. They act by mechanisms that…”
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Development and Characterization of a Human In Vitro Resorption Assay: Demonstration of Utility Using Novel Antiresorptive Agents by James, Ian E., Lark, Michael W., Zembryki, Denise, Lee‐Rykaczewski, Elizabeth V., Hwang, Shing Mei, Tomaszek, Thaddeus A., Belfiore, Pietro, Gowen, Maxine

“…A human in vitro resorption assay has been developed using osteoclastoma‐derived osteoclasts and used to evaluate novel antiresorptive agents including…”
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(2 Z,4 E)-5-(5,6-dichloro-2-indolyl)-2-methoxy-N-(1,2,2,6,6-pentamethylpiperidin-4-yl)-2,4-pentadienamide, a novel, potent and selective inhibitor of the osteoclast V-ATPase by Nadler, Guy, Morvan, Marcel, Delimoge, Isabelle, Belfiore, Pietro, Zocchetti, Andrea, James, Ian, Zembryki, Denise, Lee-Rycakzewski, Elizabeth, Parini, Carlo, Consolandi, Emanuela, Gagliardi, Stefania, Farina, Carlo

“…Optimisation of a novel series of osteoclast ATPase inhibitors led to (2 Z,4…”
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Potent and selective cathepsin L inhibitors do not inhibit human osteoclast resorption in vitro by James, Ian E., Marquis, Robert W., Blake, Simon M., Hwang, Shing Mei, Gress, Catherine J., Ru, Yu, Zembryki, Denise, Yamashita, Dennis S., McQueney, Michael S., Tomaszek, Thaddeus A., Oh, Hye-Ja, Gowen, Maxine, Veber, Daniel F., Lark, Michael W.

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Differential inhibition of histamine release from mast cells by protein kinase C inhibitors: staurosporine and K-252a by White, J R, Zembryki, D, Hanna, N, Mong, S

“…Pretreatment of rat peritoneal mast cells with either staurosporine or an analog K-252a [(8R*,9S*,11S*)-(-)-9-hydroxyl-9-methoxycarbonyl-8-methyl-2,3,…”
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