Search Results - "Zeman, Richard J"

Role of the Polyol Pathway in Locomotor Recovery and Wallerian Degeneration after Spinal Cord Contusion Injury by Zeman, Richard J., Wen, Xialing, Ouyang, Nengtai, Brown, Abraham M., Etlinger, Joseph D.

“…Spinal cord contusion injury leads to Wallerian degeneration of axonal tracts, resulting in irreversible paralysis. Contusion injury causes perfusion loss by…”
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Tempol, a Superoxide Dismutase Mimetic, Inhibits Wallerian Degeneration Following Spinal Cord Injury by Preventing Glutathione Depletion and Aldose Reductase Activation by Zeman, Richard J, Brown, Abraham M, Wen, Xialing, Ouyang, Nengtai, Etlinger, Joseph D

“…Spinal cord contusion injury results in Wallerian degeneration of spinal cord axonal tracts, which are necessary for locomotor function. Axonal swelling and…”
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Differential skeletal muscle gene expression after upper or lower motor neuron transection by Zeman, Richard J., Zhao, Jingbo, Zhang, Yuangfei, Zhao, Weidong, Wen, Xialing, Wu, Yong, Pan, Jiangping, Bauman, William A., Cardozo, Christopher

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Therapeutic target for external beam x-irradiation in experimental spinal cord injury by Zeman, Richard J, Wen, Xialing, Moorthy, Chitti R, Etlinger, Joseph D

“…X-irradiation has been shown to be beneficial to recovery from spinal cord injury (SCI); however, the optimal therapeutic target has not been defined…”
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Partial functional recovery after complete spinal cord transection by combined chondroitinase and clenbuterol treatment by Bai, Fusheng, Peng, Hong, Etlinger, Joseph D., Zeman, Richard J.

“…Spinal cord injury not only disrupts axonal tracts but also causes gliotic, fibrotic, and Schwannotic scarring with resulting deposition of chondroitin sulfate…”
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Differential skeletal muscle gene expression after upper or lower motor neuron transection by Zeman, Richard J., Zhao, Jingbo, Zhang, Yuangfei, Zhao, Weidong, Wen, Xialing, Wu, Yong, Pan, Jiangping, Bauman, William A., Cardozo, Christopher

“…Causes of disuse atrophy include loss of upper motor neurons, which occurs in spinal cord injury (SCI) or lower motor neurons (denervation). Whereas…”
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Inhibition of x-irradiation-enhanced locomotor recovery after spinal cord injury by hyperbaric oxygen or the antioxidant nitroxide tempol by HILLARD, Virany H, HONG PENG, DAS, Kaushik, MURALI, Raj, MOORTHY, Chitti R, ETLINGER, Joseph D, ZEMAN, Richard J

“…Hyperbaric oxygen (HBO), the nitroxide antioxidant tempol, and x-irradiation have been used to promote locomotor recovery in experimental models of spinal cord…”
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STEREOTACTIC RADIOSURGERY IMPROVES LOCOMOTOR RECOVERY AFTER SPINAL CORD INJURY IN RATS by Zeman, Richard J., Wen, Xialing, Ouyang, Nengtai, Rocchio, Ronald, Shih, Lynn, Alfieri, Alan, Moorthy, Chitti, Etlinger, Joseph D.

“…Abstract OBJECTIVE Currently, because of the precision of stereotactic radiosurgery, radiation can now be delivered by techniques that shape the radiation beam…”
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Improved functional recovery with oxandrolone after spinal cord injury in rats by Zeman, Richard J, Bauman, William A, Wen, Xialing, Ouyang, Nengtai, Etlinger, Joseph D, Cardozo, Christopher P

“…At present, only the corticosteroid, methylprednisolone, is used for acute spinal cord injury to improve function. However, improvements are modest, and are…”
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Clenbuterol retards loss of motor function in motor neuron degeneration mice by Zeman, Richard J., Peng, Hong, Etlinger, Joseph D.

“…Motor neuron degeneration (mnd) mice exhibit lysosomal accumulation of lipofuscin-like material that is associated with progressive loss of motor function and…”
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Tempol, a nitroxide antioxidant, improves locomotor and histological outcomes after spinal cord contusion in rats by Hillard, Virany H, Peng, Hong, Zhang, Yan, Das, Kaushik, Murali, Raj, Etlinger, Joseph D, Zeman, Richard J

“…We have determined whether the nitroxide antioxidant, tempol, can oppose tissue loss and improve recovery of locomotor function following contusion injury of…”
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Involvement of α7 Nicotinic Acetylcholine Receptors in Activation of Tyrosine Hydroxylase and Dopamine β‐Hydroxylase Gene Expression in PC12 Cells by Gueorguiev, Volodia D., Zeman, Richard J., Meyer, Edwin M., Sabban, Esther L.

“…: Nicotine treatment increases intracellular free Ca2+ concentration [Ca2+]i, stimulates catecholamine release, and elevates gene expression for the…”
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X-irradiation of the Contusion Site Improves Locomotor and Histological Outcomes in Spinal Cord-Injured Rats by Zeman, Richard J., Feng, Yong, Peng, Hong, Visintainer, Paul F., Moorthy, Chitti R., Couldwell, William T., Etlinger, Joseph D.

“…We have determined whether X-irradiation of the injury site can oppose tissue loss and improve recovery of locomotor function following contusion injury of the…”
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Differing temporal roles of Ca2+ and cAMP in nicotine-elicited elevation of tyrosine hydroxylase mRNA by Gueorguiev, V D, Zeman, R J, Hiremagalur, B, Menezes, A, Sabban, E L

“…The involvement of cAMP- and Ca2+-mediated pathways in the activation of tyrosine hydroxylase (TH) gene expression by nicotine was examined in PC-12 cells…”
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Perfusion imaging of spinal cord contusion: injury-induced blockade and partial reversal by β2-agonist treatment in rats: Laboratory investigation by Brown, Abraham, Nabel, Anna, Oh, William, Etlinger, Joseph D., Zeman, Richard J.

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Perfusion imaging of spinal cord contusion: injury-induced blockade and partial reversal by β2-agonist treatment in rats by Brown, Abraham, Nabel, Anna, Oh, William, Etlinger, Joseph D, Zeman, Richard J

“…Traumatic injury to the spinal cord results in considerable delayed tissue loss. The authors investigated the extent to which ischemia occurs following…”
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Beta2-adrenoreceptor agonist-enhanced recovery of locomotor function after spinal cord injury is glutathione dependent by Zeman, Richard J, Peng, Hong, Feng, Yong, Song, Hua, Liu, Xiaoping, Etlinger, Joseph D

“…The beta2-adrenoreceptor agonist, clenbuterol, has been shown to spare spinal cord tissue and enhance locomotor recovery in an experimental model of spinal…”
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STEREOTACTIC RADIOSURGERY IMPROVES LOCOMOTOR RECOVERY AFTER SPINAL CORD INJURY IN RATS. Commentary by ZEMAN, Richard J, XIALING WEN, DADE LUNSFORD, L, WANG, Michael Y, NENGTAI OUYANG, ROCCHIO, Ronald, SHIH, Lynn, ALFIERI, Alan, MOORTHY, Chitti, ETLINGER, Joseph D, VALADKA, Alex B, HURLBERT, R. John

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Clenbuterol, a β2-Adrenoceptor Agonist, Improves Locomotor and Histological Outcomes after Spinal Cord Contusion in Rats by Zeman, Richard J., Feng, Yong, Peng, Hong, Etlinger, Joseph D.

“…An important goal of rehabilitation following spinal cord injury is recovery of locomotor function and muscular strength. In the present studies, we determined…”
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Clenbuterol reduces degeneration of exercised or aged dystrophic (mdx) muscle by Zeman, Richard J., Peng, Hong, Danon, M. Jak, Etlinger, Joseph D.

“…Evidence of dystrophic muscle degeneration in the hind limb muscles of young (20‐week‐old) treadmill‐exercised or aged (87‐week‐old) sedentary mdx mice was…”
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