Search Results - "Zeman, E M"

Enhancement of radiation-induced tumor cell killing by the hypoxic cell toxin SR 4233 by Zeman, E M, Hirst, V K, Lemmon, M J, Brown, J M

“…SR 4233 (3-amino-1,2,4-benzotriazine 1,4-dioxide) is the lead compound in a series of benzotriazine di-N-oxides which exhibit high selective killing of hypoxic…”
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Aerobic radiosensitization by SR 4233 in rodent and human cells: mechanistic and therapeutic implications by Zeman, E M, Brown, J M

“…Mammalian cells surviving exposure to the bioreductive, cytotoxic agent SR 4233 under hypoxic conditions are sensitized to X-irradiation under aerobic…”
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The relationship between proliferative and oxygenation status in spontaneous canine tumors by Zeman, E M, Calkins, D P, Cline, J M, Thrall, D E, Raleigh, J A

“…Immunocytochemical markers have been applied to biopsy specimens from spontaneous canine tumors to assess the prevalence and spatial distribution of…”
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Development of an ELISA for the detection of 2-nitroimidazole hypoxia markers bound to tumor tissue by Raleigh, J A, Zeman, E M, Rathman, M, LaDine, J K, Cline, J M, Thrall, D E

“…Canine and rodent tumors covalently bind the fluorinated 2-nitroimidazole, CCI-103F, in a way that immunohistochemical analysis shows is consistent with the…”
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Structure-activity relationships for benzotriazine di-N-oxides by Zeman, E M, Baker, M A, Lemmon, M J, Pearson, C I, Adams, J A, Brown, J M, Lee, W W, Tracy, M

“…SR 4233 (3-amino-1,2,4-benzotriazine 1,4-dioxide) is a bioreductive agent that selectively kills and radiosensitizes hypoxic mammalian cells in vitro and…”
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Distribution of hypoxia and proliferation associated markers in spontaneous canine tumors by Raleigh, J A, Zeman, E M, Calkins, D P, McEntee, M C, Thrall, D E

“…The therapeutic response of malignant tumors depends on a number of factors associated with tumor microenvironments including the possibility that these…”
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Induction of Hypoxia in Glass versus Permanox Petri Dishes by Zeman, Elaine M., Pearson, Cecelia I., Brown, J. Martin

“…The survival of Chinese hamster ovary cells in culture following graded doses of X rays delivered under aerobic and hypoxic conditions, or treatment with the…”
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Description of a spheroid model for the study of radiation and chemotherapy effects on hypoxic tumor cell populations by Moore, D H, Rouse, M B, Massenburg, G S, Zeman, E M

“…The presence of poorly oxygenated cells in solid tumors may account for clinical resistance to ionizing radiation and some chemotherapy in many cancers…”
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Development of a United States Radiation Oncology Curricular Framework: A Stakeholder Delphi Consensus by Jeans, E., Brower, J.V., Burmeister, J.W., Deville, C., Fields, E.C., Kavanagh, B.D., Suh, J.H., Tekian, A., Vapiwala, N., Zeman, E.M., Golden, D.W.

“…A United States (US) radiation oncology (RO) curriculum, developed by key stakeholders using best practices for curriculum inquiry, is needed to guide…”
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Metabolism of SR 4233 by Chinese hamster ovary cells: basis of selective hypoxic cytotoxicity by BAKER, M. A, ZEMAN, E. M, HIRST, V. K, BROWN, J. M

“…The metabolism of SR 4233 (3-amino-1,2,4-bentotriazine-1,4-dioxide), recently reported as highly toxic to hypoxic cells in vitro, was studied by using…”
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Changes in early and late effects with dose-per-fraction: alpha, beta, redistribution and repair by Zeman, E M, Bedford, J S

“…Both tumor response and the manifestation of "early" and "late" effects in normal tissues as a function of overall treatment time and dose per fraction are…”
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SR-4233: a new bioreductive agent with high selective toxicity for hypoxic mammalian cells by Zeman, E M, Brown, J M, Lemmon, M J, Hirst, V K, Lee, W W

“…We have examined the effects of the benzotriazine di-N-oxide SR-4233 (3-amino-1,2,4-benzotriazine-1,4 dioxide) on a variety of aerobic and hypoxic cells in…”
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Tumor retention of 5-fluorouracil following irradiation observed using 19F nuclear magnetic resonance spectroscopy by Blackstock, A W, Kwock, L, Branch, C, Zeman, E M, Tepper, J E

“…The combination of 5-fluorouracil (5FU) and radiation results in improved tumor control in a variety of gastrointestinal cancers. We propose the enhancement is…”
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Aerobic radiosensitization by SR 4233 in vitro and in vivo by Zeman, E M, Lemmon, M J, Brown, J M

“…During the past 3 years, our laboratory has identified and characterized the drug SR 4233 (3-amino-1,2,4-benzotriazine 1,4-dioxide) as the lead compound in a…”
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Co-cultured transformed and untransformed C3H 10T1/2 cells: preferential killing of transformed cells by low dose rate irradiation by Zeman, E M, Bedford, J S

“…Co-cultured C3H 10T1/2 cells, in which transformed cells were grown as discrete colonies on top of density-inhibited monolayers of untransformed cells, were…”
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Loss of repair capacity in density-inhibited cultures of C3H 10T1/2 cells during multifraction irradiation by Zeman, E M, Bedford, J S

“…Multifraction survival curves for slowly cycling, density-inhibited C3H 10T1/2 cells were shown previously to bend toward lower survival levels with increasing…”
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Dose fractionation effects in plateau-phase cultures of C3H 10T1/2 cells and their transformed counterparts by Zeman, E M, Bedford, J S

“…A comparison of gamma-ray dose fractionation effects was made using plateau-phase cultures of C3H 10T1/2 cells and their transformed counterparts in an attempt…”
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Differential RBE Values Obtained for Mammary Adenocarcinoma Tumor Cell Subpopulations after 14.8-MeV Neutron Irradiation by DeWyngaert, J. Keith, Leith, John T., Peck, Russell A., Bliven, Sarah F., Zeman, Elaine M., Marino, Stephen A., Glicksman, Arvin S.

“…Four tumor cell subpopulations which were isolated from a single mouse mammary adenocarcinoma were examined for their relative sensitivities to 250-kVp X…”
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FEA on relevant biomechanical parameters involved in the success of hip prostheses: Clinical follow-up study by Zeman, M. E., Jaecques, S., Mulier, M., Van der Perre, G.

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Education and Training for Radiation Scientists: Radiation Research Program and American Society of Therapeutic Radiology and Oncology Workshop, Bethesda, Maryland, May 12-14, 2003 by Coleman, C N, Stone, H B, Alexander, G A, Barcellos-Hoff, M H, Bedford, J S, Bristow, R G, Dynlacht, J R, Fuks, Z, Gorelic, L S, Hill, R P, Joiner, M C, Liu, F, McBride, W H, McKenna, W G, Powell, S N, Robbins, MEC, Rockwell, S, Schiff, P B, Shaw, E G, Siemann, D W, Travis, EL, Wallner, P E, Wong, RSL, Zeman, E M

“…Current and potential shortfalls in the number of radiation scientists stand in sharp contrast to the emerging scientific opportunities and the need for new…”
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