Vitamin D compounds and diabetic nephropathy

Vitamin D compounds and diabetic nephropathy

► Vitamin D therapies have a long history in renal disease. ► New therapeutic targets for vitamin D compounds in this disease likely exist. ► A better understanding of disease development relative to hits on the vitamin D system is needed. ► The best vitamin D treatment regimen requires further stud...

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Bibliographic Details
Published in:Archives of biochemistry and biophysics Vol. 523; no. 1; pp. 87 - 94
Main Authors: Plum, L.A., Zella, J.B.
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01-07-2012
Subjects:
Analogs
Animals
calcium
Clinical Trials as Topic
Diabetic Nephropathies - drug therapy
Diabetic Nephropathies - pathology
Diabetic nephropathy
dialysis
disease course
Disease progression
Humans
metabolism
Molecular targets
patients
phosphorus
Renal disease
signal transduction
Signal Transduction - drug effects
Therapeutic regimen
Vitamin D
Vitamin D - analogs & derivatives
Vitamin D - pharmacology
Vitamin D - therapeutic use
Analogs
Molecular targets
Therapeutic regimen
Vitamin D
Disease progression
Renal disease
Diabetic nephropathy
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Description
Summary:► Vitamin D therapies have a long history in renal disease. ► New therapeutic targets for vitamin D compounds in this disease likely exist. ► A better understanding of disease development relative to hits on the vitamin D system is needed. ► The best vitamin D treatment regimen requires further study. Vitamin D therapies for renal disease have been used for over a half century and are likely to be utilized for many more years. Past roles have been to alter calcium and phosphorus metabolism to prevent or lessen bone disease and reduce PTH levels in dialysis patients and more recently, pre-dialysis patients. However, emerging evidence indicates new applications for vitamin D compounds are likely to exist for this patient population. In addition to the possible new targets in this therapeutic area, a popularly debated topic is the ideal form of vitamin D for use in renal disease. Because the vitamin D metabolism system is severely altered in kidney disease, a thorough understanding of the disease progression relative to the vitamin D signaling pathway is necessary. The current state of knowledge in this area with the primary focus on patients with diabetic nephropathy will be the scope of this review.
Bibliography:http://dx.doi.org/10.1016/j.abb.2012.02.008
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ISSN:0003-9861
1096-0384
DOI:10.1016/j.abb.2012.02.008