Search Results - "Zelaszczyk, Dorota"

Serotonergic system and its role in epilepsy and neuropathic pain treatment: a review based on receptor ligands by Panczyk, Katarzyna, Golda, Sylwia, Waszkielewicz, Anna, Zelaszczyk, Dorota, Gunia-Krzyzak, Agnieszka, Marona, Henryk

“…The serotonergic system is involved in pathomechanisms of both epilepsy and neuropathic pain. So far, participation in the epileptogenesis and maintenance of…”
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Anti-Helicobacter pylori activities of selected N-substituted cinnamamide derivatives evaluated on reference and clinical bacterial strains by Klesiewicz, Karolina, Karczewska, Elżbieta, Nowak, Paweł, Skiba-Kurek, Iwona, Sito, Edward, Pańczyk, Katarzyna, Koczurkiewicz, Paulina, Żelaszczyk, Dorota, Pękala, Elżbieta, Waszkielewicz, Anna M., Budak, Alicja, Marona, Henryk, Gunia-Krzyżak, Agnieszka

“…In this study, thirty-five N -substituted derivatives of cinnamic acid amide (cinnamamide) were evaluated for anti- Helicobacter pylori activity using an agar…”
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Synthesis and activity of di- or trisubstituted N-(phenoxyalkyl)- or N-{2-[2-(phenoxy)ethoxy]ethyl}piperazine derivatives on the central nervous system by Pańczyk, Katarzyna, Pytka, Karolina, Jakubczyk, Magdalena, Rapacz, Anna, Sałat, Kinga, Furgała, Anna, Siwek, Agata, Głuch-Lutwin, Monika, Gryboś, Anna, Słoczyńska, Karolina, Pękala, Elżbieta, Żmudzki, Paweł, Bucki, Adam, Kołaczkowski, Marcin, Żelaszczyk, Dorota, Marona, Henryk, Waszkielewicz, Anna M.

“…[Display omitted] •Presented compounds possess mainly antagonistic activity for serotonergic receptors.•Compound 9 showed 5-HT1A Ki = 5 nM, 5-HT7 Ki = 70 nM,…”
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Skin metabolism established with the use of MetaSite for selected retinoids employed in topical and systemic treatment of various skin disorders and found in cosmeceuticals by Słoczyńska, Karolina, Gunia-Krzyżak, Agnieszka, Żelaszczyk, Dorota, Waszkielewicz, Anna M, Marona, Henryk

“…Besides being widely used in cosmetics, retinoids are potent therapeutic agents used topically and systemically as anti-acne agents. The aim of this study was…”
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Synthesis of N‐(phenoxyalkyl)‐, N‐{2‐[2‐(phenoxy)ethoxy]ethyl}‐ or N‐(phenoxyacetyl)piperazine Derivatives and Their Activity Within the Central Nervous System by Pańczyk, Katarzyna, Pytka, Karolina, Jakubczyk, Magdalena, Rapacz, Anna, Siwek, Agata, Głuch‐Lutwin, Monika, Gryboś, Anna, Słoczyńska, Karolina, Koczurkiewicz, Paulina, Ryszawy, Damian, Pękala, Elżbieta, Budziszewska, Bogusława, Starek‐Świechowicz, Beata, Suraj‐Prażmowska, Joanna, Walczak, Maria, Żesławska, Ewa, Nitek, Wojciech, Bucki, Adam, Kołaczkowski, Marcin, Żelaszczyk, Dorota, Francik, Renata, Marona, Henryk, Waszkielewicz, Anna M.

“…Depression, anxiety and epilepsy share some etiology factors, causing frequently observed multimodal activity of centrally active compounds. This might raise…”
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Electrochemical simulation of metabolism for antitumor-active imidazoacridinone C-1311 and in silico prediction of drug metabolic reactions by Potęga, Agnieszka, Żelaszczyk, Dorota, Mazerska, Zofia

“…•Phase I metabolism of C-1311 was successfully simulated in an electrochemical cell.•The products of N-dealkylation and aliphatic hydroxylation reactions were…”
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Hyperthermia Intensifies α-Mangostin and Synthetic Xanthones' Antimalignancy Properties by Rech, Jakub, Żelaszczyk, Dorota, Marona, Henryk, Gunia-Krzyżak, Agnieszka, Żmudzki, Paweł, Bednarek, Ilona Anna

“…In order to improve naturally occurring xanthones' anticancer properties, chemical synthesis is proposed. In this study, from eight novel xanthone derivatives…”
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Metabolic stability and its role in the discovery of new chemical entities by Słoczyńska, Karolina, Gunia-Krzyżak, Agnieszka, Koczurkiewicz, Paulina, Wójcik-Pszczoła, Katarzyna, Żelaszczyk, Dorota, Popiół, Justyna, Pękala, Elżbieta

“…Determination of metabolic profiles of new chemical entities is a key step in the process of drug discovery, since it influences pharmacokinetic…”
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In silico and in vitro evaluation of a safety profile of a cosmetic ingredient: 4-methoxychalcone (4-MC) by Gunia-Krzyżak, Agnieszka, Popiół, Justyna, Słoczyńska, Karolina, Żelaszczyk, Dorota, Orzeł, Katarzyna, Koczurkiewicz-Adamczyk, Paulina, Wójcik-Pszczoła, Katarzyna, Kasza, Patryk, Borczuch-Kostańska, Magda, Pękala, Elżbieta

“…Chalcone is an important scaffold within medicinal and cosmetic chemistry. The structure enables multiple modifications which may result in obtaining compounds…”
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The Involvement of Xanthone and ( E )-Cinnamoyl Chromophores for the Design and Synthesis of Novel Sunscreening Agents by Popiół, Justyna, Gunia-Krzyżak, Agnieszka, Słoczyńska, Karolina, Koczurkiewicz-Adamczyk, Paulina, Piska, Kamil, Wójcik-Pszczoła, Katarzyna, Żelaszczyk, Dorota, Krupa, Anna, Żmudzki, Paweł, Marona, Henryk, Pękala, Elżbieta

“…Excessive UV exposure contributes to several pathological conditions like skin burns, erythema, premature skin aging, photodermatoses, immunosuppression, and…”
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In vitro safety evaluation of (6-methoxy-9-oxo-9 H -xanthen-2-yl)methyl ( E )-3-(2,4-dimethoxyphenyl)acrylate (K-116) - the novel potential UV filter designed by means of a double chromophore strategy by Popiół, Justyna, Gunia-Krzyżak, Agnieszka, Słoczyńska, Karolina, Piska, Kamil, Kocot, Natalia, Żelaszczyk, Dorota, Krupa, Anna, Wójcik-Pszczoła, Katarzyna, Marona, Henryk, Pękala, Elżbieta

“…The use of topical photoprotection is necessary to reduce adverse effects caused by excessive exposure to ultraviolet radiation. Despite the high standards set…”
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HBK-10, A Compound with α1-Adrenolytic Properties, Showed Antiarrhythmic and Hypotensive Effects in Rats by Lustyk, Klaudia, Sałaciak, Kinga, Siwek, Agata, Filipek, Barbara, Sapa, Jacek, Marona, Henryk, Żelaszczyk, Dorota, Pytka, Karolina

“…Arrhythmia, an irregular heartbeat, might be a life-threatening condition but also a risk factor for stroke or worsen the prognosis after myocardial…”
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S (+)-(2 E )- N -(2-Hydroxypropyl)-3-Phenylprop-2-Enamide (KM-568): A Novel Cinnamamide Derivative with Anticonvulsant Activity in Animal Models of Seizures and Epilepsy by Gunia-Krzyżak, Agnieszka, Żesławska, Ewa, Słoczyńska, Karolina, Żelaszczyk, Dorota, Sowa, Aleksandra, Koczurkiewicz-Adamczyk, Paulina, Popiół, Justyna, Nitek, Wojciech, Pękala, Elżbieta, Marona, Henryk

“…Epilepsy is one of the most frequent neurological disorders affecting about 1% of the world's human population. Despite availability of multiple treatment…”
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Electrochemical and in silico approaches for liver metabolic oxidation of antitumor-active triazoloacridinone C-1305 by Potęga, Agnieszka, Żelaszczyk, Dorota, Mazerska, Zofia

“…5-Dimethylaminopropylamino-8-hydroxytriazoloacridinone (C-1305) is a promising antitumor compound developed in our laboratory. A better understanding of its…”
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Microbial biotransformation of some novel hydantoin derivatives: Perspectives for bioremediation of potential sunscreen agents by Popiół, Justyna, Piska, Kamil, Słoczyńska, Karolina, Bień, Anna, Żelaszczyk, Dorota, Gunia-Krzyżak, Agnieszka, Koczurkiewicz, Paulina, Wójcik-Pszczoła, Katarzyna, Marona, Henryk, Pękala, Elżbieta

“…Having identified novel hydantoin derivatives (compounds 1–5) demonstrating promising photoprotective capacity against UV radiation, and understainding the…”
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Novel Xanthone Derivatives Impair Growth and Invasiveness of Colon Cancer Cells In Vitro by Rech, Jakub, Sypniewski, Daniel, Żelaszczyk, Dorota, Szkaradek, Natalia, Rogóż, Wojciech, Waszkielewicz, Anna, Marona, Henryk, Bednarek, Ilona

“…Natural xanthones are a large group of compounds from which promising anticancer properties could be further developed by chemical modifications. This study…”
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Discovery of Novel UV-Filters with Favorable Safety Profiles in the 5-Arylideneimidazolidine-2,4-dione Derivatives Group by Popiół, Justyna, Gunia-Krzyżak, Agnieszka, Piska, Kamil, Żelaszczyk, Dorota, Koczurkiewicz, Paulina, Słoczyńska, Karolina, Wójcik-Pszczoła, Katarzyna, Krupa, Anna, Kryczyk-Poprawa, Agata, Żesławska, Ewa, Nitek, Wojciech, Żmudzki, Paweł, Marona, Henryk, Pękala, Elżbieta

“…Effective protection from the harmful effects of UV radiation may be achieved by using sunscreens containing organic or inorganic UV filters. The number of…”
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Design, synthesis and evaluation of activity and pharmacokinetic profile of new derivatives of xanthone and piperazine in the central nervous system by Żelaszczyk, Dorota, Jakubczyk, Magdalena, Pytka, Karolina, Rapacz, Anna, Walczak, Maria, Janiszewska, Paulina, Pańczyk, Katarzyna, Żmudzki, Paweł, Słoczyńska, Karolina, Marona, Henryk, Waszkielewicz, Anna M.

“…[Display omitted] Searching for CNS active cyclic amines derivatives containing heterocyclic xanthone core we designed and synthesized a set of fourteen novel…”
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Antibacterial and antibiofilm agents in the group of xanthone derivatives with piperazine moiety active against drug-resistant Helicobacter pylori strains by Żelaszczyk, Dorota, Chmiel, Aneta, Gunia-Krzyżak, Agnieszka, Marona, Henryk, Krzyżek, Paweł, Dworak, Kinga, Skiba-Kurek, Iwona, Karczewska, Elżbieta, Popiół, Justyna, Pękala, Elżbieta, Żmudzki, Paweł, Ziąbka, Magdalena, Klesiewicz, Karolina

“…[Display omitted] •Xanthone Derivatives as Potential Therapeutics.•C11 & C12 with benzylpiperazine demonstrated selective bacteriostatic activity against H…”
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Discovery of (E)-3-(4-chlorophenyl)-N-(5-hydroxypentyl)acrylamide among N-substituted cinnamamide derivatives as a novel cosmetic ingredient for hyperpigmentation by Gunia-Krzyżak, Agnieszka, Popiół, Justyna, Słoczyńska, Karolina, Żelaszczyk, Dorota, Koczurkiewicz-Adamczyk, Paulina, Wójcik-Pszczoła, Katarzyna, Bucki, Adam, Sapa, Michał, Kasza, Patryk, Borczuch-Kostańska, Magda, Marona, Henryk, Pękala, Elżbieta

“…[Display omitted] •Cinnamamide derivatives possess potential to treat hyperpigmentation.•Cinnamamide derivative inhibited expression of melanogenesis-related…”
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