Search Results - "Zeki, Amir A."

Pleiotropic effects of statins: A focus on cancer by Ahmadi, Mazaher, Amiri, Shayan, Pecic, Stevan, Machaj, Filip, Rosik, Jakub, Łos, Marek J., Alizadeh, Javad, Mahdian, Reza, da Silva Rosa, Simone C., Schaafsma, Dedmer, Shojaei, Shahla, Madrakian, Tayyebeh, Zeki, Amir A., Ghavami, Saeid

“…The statin drugs (‘statins’) potently inhibit hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase by competitively blocking the active site of the enzyme…”
Get full text

Targeting cholesterol metabolism in glioblastoma: a new therapeutic approach in cancer therapy by Pirmoradi, Leila, Seyfizadeh, Nayer, Ghavami, Saeid, Zeki, Amir A, Shojaei, Shahla

“…Glioblastoma multiforme (GBM) is the most aggressive malignant brain tumor known with a poor survival rate despite current advances in the field of cancer…”
Get full text

Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease by YEGANEH, Behzad, WIECHEC, Emilia, GHAVAMI, Saeid, ANDE, Sudharsana R, SHARMA, Pawan, ADEL REZAEI MOGHADAM, POST, Martin, FREED, Darren H, HASHEMI, Mohammad, SHOJAEI, Shahla, ZEKI, Amir A

“…The cholesterol biosynthesis pathway, also known as the mevalonate (MVA) pathway, is an essential cellular pathway that is involved in diverse cell functions…”
Get full text

Interstitial Lung Disease in Connective Tissue Disease: A Common Lesion With Heterogeneous Mechanisms and Treatment Considerations by Shao, Tihong, Shi, Xiaodong, Yang, Shanpeng, Zhang, Wei, Li, Xiaohu, Shu, Jingwei, Alqalyoobi, Shehabaldin, Zeki, Amir A, Leung, Patrick S, Shuai, Zongwen

“…Connective tissue disease (CTD) related interstitial lung disease (CTD-ILD) is one of the leading causes of morbidity and mortality of CTD. Clinically, CTD-ILD…”
Get full text

Animal models and mechanisms of tobacco smoke-induced chronic obstructive pulmonary disease (COPD) by Upadhyay, Priya, Wu, Ching-Wen, Pham, Alexa, Zeki, Amir A., Royer, Christopher M., Kodavanti, Urmila P., Takeuchi, Minoru, Bayram, Hasan, Pinkerton, Kent E.

“…Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide, and its global health burden is increasing. COPD is characterized…”
Get full text

Mevalonate Cascade Inhibition by Simvastatin Induces the Intrinsic Apoptosis Pathway via Depletion of Isoprenoids in Tumor Cells by Alizadeh, Javad, Zeki, Amir A., Mirzaei, Nima, Tewary, Sandipan, Rezaei Moghadam, Adel, Glogowska, Aleksandra, Nagakannan, Pandian, Eftekharpour, Eftekhar, Wiechec, Emilia, Gordon, Joseph W., Xu, Fred. Y., Field, Jared T., Yoneda, Ken Y., Kenyon, Nicholas J., Hashemi, Mohammad, Hatch, Grant M., Hombach-Klonisch, Sabine, Klonisch, Thomas, Ghavami, Saeid

“…The mevalonate (MEV) cascade is responsible for cholesterol biosynthesis and the formation of the intermediate metabolites geranylgeranylpyrophosphate (GGPP)…”
Get full text

Emerging Advances of Nanotechnology in Drug and Vaccine Delivery against Viral Associated Respiratory Infectious Diseases (VARID) by Seyfoori, Amir, Shokrollahi Barough, Mahdieh, Mokarram, Pooneh, Ahmadi, Mazaher, Mehrbod, Parvaneh, Sheidary, Alireza, Madrakian, Tayyebeh, Kiumarsi, Mohammad, Walsh, Tavia, McAlinden, Kielan D, Ghosh, Chandra C, Sharma, Pawan, Zeki, Amir A, Ghavami, Saeid, Akbari, Mohsen

“…Viral-associated respiratory infectious diseases are one of the most prominent subsets of respiratory failures, known as viral respiratory infections (VRI)…”
Get full text

Autophagy, Apoptosis, the Unfolded Protein Response, and Lung Function in Idiopathic Pulmonary Fibrosis by Sharma, Pawan, Alizadeh, Javad, Juarez, Maya, Samali, Afshin, Halayko, Andrew J, Kenyon, Nicholas J, Ghavami, Saeid, Zeki, Amir A

“…Autophagy, apoptosis, and the unfolded protein response (UPR) are fundamental biological processes essential for manifold cellular functions in health and…”
Get full text

The asthma-chronic obstructive pulmonary disease overlap syndrome: pharmacotherapeutic considerations by Louie, Samuel, Zeki, Amir A, Schivo, Michael, Chan, Andrew L, Yoneda, Ken Y, Avdalovic, Mark, Morrissey, Brian M, Albertson, Timothy E

“…Asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) is a commonly encountered yet loosely defined clinical entity. ACOS accounts for…”
Get more information

The ER Stress/UPR Axis in Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis by Aghaei, Mahmoud, Dastghaib, Sanaz, Aftabi, Sajjad, Aghanoori, Mohamad-Reza, Alizadeh, Javad, Mokarram, Pooneh, Mehrbod, Parvaneh, Ashrafizadeh, Milad, Zarrabi, Ali, McAlinden, Kielan Darcy, Eapen, Mathew Suji, Sohal, Sukhwinder Singh, Sharma, Pawan, Zeki, Amir A, Ghavami, Saeid

“…Cellular protein homeostasis in the lungs is constantly disrupted by recurrent exposure to various external and internal stressors, which may cause…”
Get full text

Eosinophilic and Noneosinophilic Asthma by Carr, Tara F, Zeki, Amir A, Kraft, Monica

“…The term “eosinophilic” asthma (EA) generally refers to the clinical inflammatory phenotype of asthma wherein a significant number of sputum, airway, and/or…”
Get full text

Self-assembling nanoparticles containing dexamethasone as a novel therapy in allergic airways inflammation by Kenyon, Nicholas J, Bratt, Jennifer M, Lee, Joyce, Luo, Juntao, Franzi, Lisa M, Zeki, Amir A, Lam, Kit S

“…Nanocarriers can deliver a wide variety of drugs, target them to sites of interest, and protect them from degradation and inactivation by the body. They have…”
Get full text

The effects of dual IQOS and cigarette smoke exposure on airway epithelial cells: implications for lung health and respiratory disease pathogenesis by Saha, Pritam, Jain, Siddhi, Mukherjee, Ipsita, Panda, Samir R, Zeki, Amir A, Naidu, V G M, Sharma, Pawan

“…Cigarette smoking remains a primary cause of chronic lung diseases. After a steady decline, smoking rates have recently increased especially with the…”
Get full text

Simvastatin inhibits smoke-induced airway epithelial injury: implications for COPD therapy by DAVIS, Benjamin B, ZEKI, Amir A, BRATT, Jennifer M, LEI WANG, FILOSTO, Simone, WALBY, William F, KENYON, Nicholas J, GOLDKORN, Tzipora, SCHELEGLE, Edward S, PINKERTON, Kent E

“…Chronic obstructive pulmonary disease (COPD) is the third leading cause of death. The statin drugs may have therapeutic potential in respiratory diseases such…”
Get full text

Differential effects of simvastatin on IL-13-induced cytokine gene expression in primary mouse tracheal epithelial cells by Zeki, Amir A, Thai, Phil, Kenyon, Nicholas J, Wu, Reen

“…Asthma causes significant morbidity worldwide in adults and children alike, and incurs large healthcare costs. The statin drugs, which treat hyperlipidemia and…”
Get full text

Inhibiting Airway Smooth Muscle Contraction Using Pitavastatin: A Role for the Mevalonate Pathway in Regulating Cytoskeletal Proteins by Lu, Robin A, Zeki, Amir A, Ram-Mohan, Sumati, Nguyen, Nhan, Bai, Yan, Chmiel, Kenneth, Pecic, Stevan, Ai, Xingbin, Krishnan, Ramaswamy, Ghosh, Chandra C

“…Despite maximal use of currently available therapies, a significant number of asthma patients continue to experience severe, and sometimes life-threatening…”
Get full text

Heart of the Matter: Syncope as a Rare Presentation of Lung Cancer Invading the Heart by Al-Juburi, Saleh, Rafizadeh, Sassan, Zeki, Amir A.

“…Syncope is common, affecting approximately 1 million Americans every year. Although multiple pathophysiological mechanisms regarding its etiology have been…”
Get full text

Inhalational exposure to statins and drug vehicle induces transient immunological changes in both the airways and peripheral blood of non-human primates by Killingbeck, Sarah, Ott, Sean, Ge, Moyar Qing, PhD, Flayer, Cameron H, Miller, Lisa, Christofidou-Solomidou, Melpo, Zeki, Amir A., MD, Haczku, Angela, MD, PhD, FAAAAI

“…Differential cell counts and immune phenotyping (from blood, bronchoalveolar lavage [BAL] and thoracic lymph nodes [LN]) were performed by flow cytometry and…”
Get full text

Editorial: New Insights into a Classical Pathway: Key Roles of the Mevalonate Cascade in Different Diseases (Part II) by Zeki, Amir A, Yeganeh, Behzad, Kenyon, Nicholas J, Ghavami, Saeid

Get more information

Does Vaping Increase Susceptibility to COVID-19? by Sharma, Pawan, Zeki, Amir A

Get full text