Search Results - "Zekavat, Seyedeh"

Whole-Genome Sequencing to Characterize Monogenic and Polygenic Contributions in Patients Hospitalized With Early-Onset Myocardial Infarction by Khera, Amit V., Chaffin, Mark, Zekavat, Seyedeh M., Collins, Ryan L., Roselli, Carolina, Natarajan, Pradeep, Lichtman, Judith H., D’Onofrio, Gail, Mattera, Jennifer, Dreyer, Rachel, Spertus, John A., Taylor, Kent D., Psaty, Bruce M., Rich, Stephen S., Post, Wendy, Gupta, Namrata, Gabriel, Stacey, Lander, Eric, Ida Chen, Yii-Der, Talkowski, Michael E., Rotter, Jerome I., Krumholz, Harlan M., Kathiresan, Sekar

“…BACKGROUND:The relative prevalence and clinical importance of monogenic mutations related to familial hypercholesterolemia and of high polygenic score…”
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Distinction of lymphoid and myeloid clonal hematopoiesis by Niroula, Abhishek, Sekar, Aswin, Murakami, Mark A., Trinder, Mark, Agrawal, Mridul, Wong, Waihay J., Bick, Alexander G., Uddin, Md Mesbah, Gibson, Christopher J., Griffin, Gabriel K., Honigberg, Michael C., Zekavat, Seyedeh M., Paruchuri, Kaavya, Natarajan, Pradeep, Ebert, Benjamin L.

“…Clonal hematopoiesis (CH) results from somatic genomic alterations that drive clonal expansion of blood cells. Somatic gene mutations associated with…”
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Genetic Association of Waist-to-Hip Ratio With Cardiometabolic Traits, Type 2 Diabetes, and Coronary Heart Disease by Emdin, Connor A, Khera, Amit V, Natarajan, Pradeep, Klarin, Derek, Zekavat, Seyedeh M, Hsiao, Allan J, Kathiresan, Sekar

“…IMPORTANCE: In observational studies, abdominal adiposity has been associated with type 2 diabetes and coronary heart disease (CHD). Whether these associations…”
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Cardiovascular and Kidney Outcomes Across the Glycemic Spectrum: Insights From the UK Biobank by Honigberg, Michael C, Zekavat, Seyedeh M, Pirruccello, James P, Natarajan, Pradeep, Vaduganathan, Muthiah

“…Treatment guidelines for prediabetes primarily focus on glycemic control and lifestyle management. Few evidence-based cardiovascular and kidney risk-reduction…”
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ANGPTL3 Deficiency and Protection Against Coronary Artery Disease by Stitziel, Nathan O., MD, PhD, Khera, Amit V., MD, Wang, Xiao, PhD, Bierhals, Andrew J., MD, MPH, Vourakis, A. Christina, BA, Sperry, Alexandra E., BA, Natarajan, Pradeep, MD, Klarin, Derek, MD, Emdin, Connor A., DPhil, Zekavat, Seyedeh M., BSc, Nomura, Akihiro, MD, Erdmann, Jeanette, PhD, Schunkert, Heribert, MD, Samani, Nilesh J., MD, Kraus, William E., MD, Shah, Svati H., MD, MPH, Yu, Bing, PhD, Boerwinkle, Eric, PhD, Rader, Daniel J., MD, Gupta, Namrata, PhD, Frossard, Philippe M., PhD, Rasheed, Asif, MBBS, Danesh, John, DPhil, Lander, Eric S., PhD, Gabriel, Stacey, PhD, Saleheen, Danish, MBBS, PhD, Musunuru, Kiran, MD, PhD, MPH, Kathiresan, Sekar, MD

“…Abstract Background Familial combined hypolipidemia, a Mendelian condition characterized by substantial reductions in all 3 major lipid fractions, is caused by…”
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Genetic IL-6 Signaling Modifies Incident Coronary Artery Disease Risk in Chronic Kidney Disease by Yu, Zhi, Zekavat, Seyedeh M, Honigberg, Michael C, Natarajan, Pradeep

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Premature Menopause, Clonal Hematopoiesis, and Coronary Artery Disease in Postmenopausal Women by Honigberg, Michael C, Zekavat, Seyedeh M, Niroula, Abhishek, Griffin, Gabriel K, Bick, Alexander G, Pirruccello, James P, Nakao, Tetsushi, Whitsel, Eric A, Farland, Leslie V, Laurie, Cecelia, Kooperberg, Charles, Manson, JoAnn E, Gabriel, Stacey, Libby, Peter, Reiner, Alexander P, Ebert, Benjamin L, Natarajan, Pradeep

“…Premature menopause is an independent risk factor for cardiovascular disease in women, but mechanisms underlying this association remain unclear. Clonal…”
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A Genetic Variant Associated with Five Vascular Diseases Is a Distal Regulator of Endothelin-1 Gene Expression by Gupta, Rajat M., Hadaya, Joseph, Trehan, Aditi, Zekavat, Seyedeh M., Roselli, Carolina, Klarin, Derek, Emdin, Connor A., Hilvering, Catharina R.E., Bianchi, Valerio, Mueller, Christian, Khera, Amit V., Ryan, Russell J.H., Engreitz, Jesse M., Issner, Robbyn, Shoresh, Noam, Epstein, Charles B., de Laat, Wouter, Brown, Jonathan D., Schnabel, Renate B., Bernstein, Bradley E., Kathiresan, Sekar

“…Genome-wide association studies (GWASs) implicate the PHACTR1 locus (6p24) in risk for five vascular diseases, including coronary artery disease, migraine…”
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Genetics of smoking and risk of clonal hematopoiesis by Levin, Michael G., Nakao, Tetsushi, Zekavat, Seyedeh M., Koyama, Satoshi, Bick, Alexander G., Niroula, Abhishek, Ebert, Benjamin, Damrauer, Scott M., Natarajan, Pradeep

“…Clonal hematopoiesis of indeterminate potential (CHIP) and mosaic chromosomal alterations (mCAs) represent two forms of clonal hematopoiesis where clones…”
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Microvascular Outcomes in Women With a History of Hypertension in Pregnancy by Honigberg, Michael C., Zekavat, Seyedeh M., Raghu, Vineet K., Natarajan, Pradeep

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Clonal Hematopoiesis Is Associated With Higher Risk of Stroke by Bhattacharya, Romit, Zekavat, Seyedeh M., Haessler, Jeffrey, Fornage, Myriam, Raffield, Laura, Uddin, Md Mesbah, Bick, Alexander G., Niroula, Abhishek, Yu, Bing, Gibson, Christopher, Griffin, Gabriel, Morrison, Alanna C., Psaty, Bruce M., Longstreth, William T., Bis, Joshua C., Rich, Stephen S., Rotter, Jerome I., Tracy, Russell P., Correa, Adolfo, Seshadri, Sudha, Johnson, Andrew, Collins, Jason M., Hayden, Kathleen M., Madsen, Tracy E., Ballantyne, Christie M., Jaiswal, Siddhartha, Ebert, Benjamin L., Kooperberg, Charles, Manson, JoAnn E., Whitsel, Eric A., Natarajan, Pradeep, Reiner, Alexander P.

“…Clonal hematopoiesis of indeterminate potential (CHIP) is a novel age-related risk factor for cardiovascular disease-related morbidity and mortality. The…”
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Genetic Association of Finger Photoplethysmography-Derived Arterial Stiffness Index With Blood Pressure and Coronary Artery Disease by Zekavat, Seyedeh M, Aragam, Krishna, Emdin, Connor, Khera, Amit V, Klarin, Derek, Zhao, Hongyu, Natarajan, Pradeep

“…OBJECTIVE—Arterial stiffness index (ASI) is independently associated with blood pressure (BP) and coronary artery disease (CAD) epidemiologically. However, it…”
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Genetic modification of inflammation- and clonal hematopoiesis-associated cardiovascular risk by Yu, Zhi, Fidler, Trevor P, Ruan, Yunfeng, Vlasschaert, Caitlyn, Nakao, Tetsushi, Uddin, Md Mesbah, Mack, Taralynn, Niroula, Abhishek, Heimlich, J Brett, Zekavat, Seyedeh M, Gibson, Christopher J, Griffin, Gabriel K, Wang, Yuxuan, Peloso, Gina M, Heard-Costa, Nancy, Levy, Daniel, Vasan, Ramachandran S, Aguet, François, Ardlie, Kristin G, Taylor, Kent D, Rich, Stephen S, Rotter, Jerome I, Libby, Peter, Jaiswal, Siddhartha, Ebert, Benjamin L, Bick, Alexander G, Tall, Alan R, Natarajan, Pradeep

“…Clonal hematopoiesis of indeterminate potential (CHIP) is associated with an increased risk of cardiovascular diseases (CVDs), putatively via inflammasome…”
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Phenotypic Consequences of a Genetic Predisposition to Enhanced Nitric Oxide Signaling by Emdin, Connor A, Khera, Amit V, Klarin, Derek, Natarajan, Pradeep, Zekavat, Seyedeh M, Nomura, Akihiro, Haas, Mary, Aragam, Krishna, Ardissino, Diego, Wilson, James G, Schunkert, Heribert, McPherson, Ruth, Watkins, Hugh, Elosua, Roberto, Bown, Matthew J, Samani, Nilesh J, Baber, Usman, Erdmann, Jeanette, Gormley, Padhraig, Palotie, Aarno, Stitziel, Nathan O, Gupta, Namrata, Danesh, John, Saleheen, Danish, Gabriel, Stacey, Kathiresan, Sekar

“…BACKGROUND—Nitric oxide signaling plays a key role in regulation of vascular tone and platelet activation. Here, we seek to understand the impact of a genetic…”
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Independent Effects of Blood Pressure on Intraocular Pressure and Retinal Ganglion Cell Degeneration: A Mendelian Randomization Study by Rajasundaram, Skanda, Segrè, Ayellet V, Gill, Dipender, Woolf, Benjamin, Zekavat, Seyedeh M, Burgess, Stephen, Khawaja, Anthony P, Zebardast, Nazlee, Wiggs, Janey L

“…To investigate the causal effect of elevated blood pressure on primary open-angle glaucoma (POAG) and POAG endophenotypes. Two-sample Mendelian randomization…”
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Phenotypic Characterization of Genetically Lowered Human Lipoprotein(a) Levels by Emdin, Connor A., DPhil, Khera, Amit V., MD, Natarajan, Pradeep, MD, Klarin, Derek, MD, Won, Hong-Hee, PhD, Peloso, Gina M., PhD, Stitziel, Nathan O., MD, PhD, Nomura, Akihiro, MD, Zekavat, Seyedeh M., BSc, Bick, Alexander G., MD, Gupta, Namrata, PhD, Asselta, Rosanna, PhD, Duga, Stefano, PhD, Merlini, Piera Angelica, MD, Correa, Adolfo, MD, Kessler, Thorsten, MD, Wilson, James G., MD, Bown, Matthew J., MD, Hall, Alistair S., MD, Braund, Peter S., PhD, Samani, Nilesh J., MD, Schunkert, Heribert, MD, Marrugat, Jaume, MD, PhD, Elosua, Roberto, MD, PhD, McPherson, Ruth, MD, Farrall, Martin, PhD, Watkins, Hugh, MD, PhD, Willer, Cristen, PhD, Abecasis, Gonçalo R., PhD, Felix, Janine F., MD, PhD, Vasan, Ramachandran S., MD, Lander, Eric, PhD, Rader, Daniel J., MD, Danesh, John, MSc, DPhil, Ardissino, Diego, MD, Gabriel, Stacey, PhD, Saleheen, Danish, MD, Kathiresan, Sekar, MD

“…Abstract Background Genomic analyses have suggested that the LPA gene and its associated plasma biomarker, lipoprotein(a) (Lp[a]), represent a causal risk…”
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An in silico model of retinal cholesterol dynamics (RCD model): insights into the pathophysiology of dry AMD by Zekavat, Seyedeh Maryam, Lu, James, Maugeais, Cyrille, Mazer, Norman A.

“…We developed an in silico mathematical model of retinal cholesterol (Ch) dynamics (RCD) to quantify the physiological rate of Ch turnover in the rod outer…”
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Long-Term Cardiovascular Risk in Women With Hypertension During Pregnancy by Honigberg, Michael C., Zekavat, Seyedeh Maryam, Aragam, Krishna, Klarin, Derek, Bhatt, Deepak L., Scott, Nandita S., Peloso, Gina M., Natarajan, Pradeep

“…History of a hypertensive disorder of pregnancy (HDP) among women may be useful to refine atherosclerotic cardiovascular disease risk assessments. However,…”
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Mathematical framework for activity-based cancer biomarkers by Kwong, Gabriel A., Dudani, Jaideep S., Carrodeguas, Emmanuel, Mazumdar, Eric V., Zekavat, Seyedeh M., Bhatia, Sangeeta N.

“…Advances in nanomedicine are providing sophisticated functions to precisely control the behavior of nanoscale drugs and diagnostics. Strategies that coopt…”
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DNA Sequence Variation in ACVR1C Encoding the Activin Receptor-Like Kinase 7 Influences Body Fat Distribution and Protects Against Type 2 Diabetes by Emdin, Connor A, Khera, Amit V, Aragam, Krishna, Haas, Mary, Chaffin, Mark, Klarin, Derek, Natarajan, Pradeep, Bick, Alexander, Zekavat, Seyedeh M, Nomura, Akihiro, Ardissino, Diego, Wilson, James G, Schunkert, Heribert, McPherson, Ruth, Watkins, Hugh, Elosua, Roberto, Bown, Matthew J, Samani, Nilesh J, Baber, Usman, Erdmann, Jeanette, Gupta, Namrata, Danesh, John, Saleheen, Danish, Gabriel, Stacey, Kathiresan, Sekar

“…A genetic predisposition to higher waist-to-hip ratio adjusted for BMI (WHRadjBMI), a measure of body fat distribution, associates with increased risk for type…”
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