Search Results - "Zeitschel, U."

Cellular and ultra structural evidence for cytoskeletal localization of prolyl endopeptidase-like protein in neurons by Morawski, M, Nuytens, K, Juhasz, T, Zeitschel, U, Seeger, G, Waelkens, E, Regal, L, Schulz, I, Arendt, T, Szeltner, Z, Creemers, J, Roßner, S

“…Graphical abstract Highlights ► PREPL deficiency affects the abundance of cytoskeletal proteins. ► PREPL is co-localized with cytoskeletal proteins in mouse…”
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Role of prolyl endopeptidase in intracellular transport and protein secretion by Morawski, M, Schulz, I, Zeitschel, U, Blosa, M, Seeger, G, Rossner, S

“…Prolyl endopeptidase (E.C. 3.4.21.26, PREP) also known as prolyl oligopeptidase is an enzyme which cleaves several peptides at the carboxyl side of proline…”
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Bepridil and Amiodarone Simultaneously Target the Alzheimer's Disease  - and  -Secretase via Distinct Mechanisms by Mitterreiter, S., Page, R. M., Kamp, F., Hopson, J., Winkler, E., Ha, H.-R., Hamid, R., Herms, J., Mayer, T. U., Nelson, D. J., Steiner, H., Stahl, T., Zeitschel, U., Rossner, S., Haass, C., Lichtenthaler, S. F.

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Cellular distribution of 6-phosphofructo-1-kinase isoenzymes in rat brain by Zeitschel, U, Bigl, M, Eschrich, K, Bigl, V

“…In the brain, all three isoenzyme types [muscle (M), liver (L), and brain (C)] of 6-phosphofructo-1-kinase (PFK; EC 2.7.1.11) occur, forming a complex mixture…”
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Proteolytic degradation of neuropeptide Y (NPY) from head to toe: Identification of novel NPY‐cleaving peptidases and potential drug interactions in CNS and Periphery by Wagner, Leona, Wolf, Raik, Zeitschel, Ulrike, Rossner, Steffen, Petersén, Åsa, Leavitt, Blair R., Kästner, Florian, Rothermundt, Matthias, Gärtner, Ulf‐Torsten, Gündel, Daniel, Schlenzig, Dagmar, Frerker, Nadine, Schade, Jutta, Manhart, Susanne, Rahfeld, Jens‐Ulrich, Demuth, Hans‐Ulrich, Hörsten, Stephan

“…The bioactivity of neuropeptide Y (NPY) is either N‐terminally modulated with respect to receptor selectivity by dipeptidyl peptidase 4 (DP4)‐like enzymes or…”
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Alzheimer's disease β‐secretase BACE1 is not a neuron‐specific enzyme by Roßner, Steffen, Lange‐Dohna, Christine, Zeitschel, Ulrike, Perez‐Polo, J. Regino

“…The brains of Alzheimer's disease (AD) patients are morphologically characterized by neurofibrillar abnormalities and by parenchymal and cerebrovascular…”
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Three-dimensional micro-structures for the embedding of living cells by Otte, K., Zimmer, K., Zeitschel, U., Braun, A., Hirsch, D., Bigl, F., Bigl, V.

“…AFM (atomic-force microscope) studies of living cells have been of considerable interest since the invention of the technique itself. However, due to the…”
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[P1.70]: Immortalized mouse hypothalamic GT1‐7 neurons as cell culture model for glutaminyl cyclase function by Zeitschel, U., Popelka, N., Rübsamen, M. Hartlage

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The transcription factor Yin Yang 1 is an activator of BACE1 expression by Nowak, Katrin, Lange‐Dohna, Christine, Zeitschel, Ulrike, Günther, Albrecht, Lüscher, Bernhard, Robitzki, Andrea, Perez‐Polo, Regino, Roßner, Steffen

“…The β‐site amyloid precursor protein‐cleaving enzyme 1 (BACE1) is a prerequisite for the generation of β‐amyloid peptides, the principle constituents of senile…”
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Astrocytic expression of the Alzheimer's disease β-secretase (BACE1) is stimulus-dependent by Hartlage-Rübsamen, Maike, Zeitschel, Ulrike, Apelt, Jenny, Gärtner, Ulrich, Franke, Heike, Stahl, Tobias, Günther, Albrecht, Schliebs, Reinhard, Penkowa, Milena, Bigl, Volker, Roßner, Steffen

“…The beta‐site APP‐cleaving enzyme (BACE1) is a prerequisite for the generation of β‐amyloid peptides, which give rise to cerebrovascular and parenchymal…”
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Subcellular localization suggests novel functions for prolyl endopeptidase in protein secretion by Schulz, Ingo, Zeitschel, Ulrike, Rudolph, Thomas, Ruiz‐Carrillo, David, Rahfeld, Jens‐Ulrich, Gerhartz, Bernd, Bigl, Volker, Demuth, Hans‐Ulrich, Roßner, Steffen

“…For a long time, prolyl endopeptidase (PEP) was believed to inactivate neuropeptides in the extracellular space. However, reports on the intracellular activity…”
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Brain prolyl endopeptidase expression in aging, APP transgenic mice and Alzheimer's disease by Rossner, Steffen, Schulz, Ingo, Zeitschel, Ulrike, Schliebs, Reinhard, Bigl, Volker, Demuth, Hans-Ulrich

“…Prolyl endopeptidase (PEP) is believed to inactivate neuropeptides that are present in the extracellular space. However, the intracellular localization of PEP…”
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Cloning and expression of the rat BACE1 promoter by Lange-Dohna, Christine, Zeitschel, Ulrike, Gaunitz, Frank, Perez-Polo, J. Regino, Bigl, Volker, Roßner, Steffen

“…The pathogenic processing of the amyloid precursor protein (APP) into β‐amyloid peptides, which give rise to β‐amyloid plaques in the brains of Alzheimer's…”
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Changes in activity and expression of phosphofructokinase in different rat brain regions after basal forebrain cholinergic lesion by Zeitschel, Ulrike, Schliebs, Reinhard, Roßner, Steffen, Bigl, Volker, Eschrich, Klaus, Bigl, Marina

“…Selective lesion of rat basal forebrain by the cholinergic immunotoxin 192IgG‐saporin was used as an animal model to address the question of whether the…”
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MK 801 attenuates c-Fos and c-Jun expression after in vitro ischemia in rat neuronal cell cultures but not in PC 12 cells by Gerlach, Rüdiger, Beck, Mike, Zeitschel, Ulrike, Seifert, Volker

“…Cellular homeostatic adaptation to cerebral ischemia is complex and contains changes in receptor mediated gene expression and signaling pathways. The proteins…”
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Chymotrypsin-catalyzed peptide synthesis in an acetonitrile-water-system: studies on the efficiency of nucleophiles by Fischer, U, Zeitschel, U, Jakubke, H D

“…Peptide synthesis with chymotrypsin in organic solvents was investigated and the apparent partition constants have been measured. We find that the Papp values…”
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Cerebrospinal fluid cholinesterases--markers for loss of cholinergic basal forebrain neurons? by Rossner, S, Bakinde, N, Zeitschel, U, Schliebs, R, Bigl, V

“…The present study was conducted to test the hypothesis that cholinergic basal forebrain neurons are a major source of cerebrospinal fluid (CSF)…”
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