Search Results - "Zeitler, Axel"

A Review of Disintegration Mechanisms and Measurement Techniques by Markl, Daniel, Zeitler, J. Axel

“…ABSTRACT Pharmaceutical solid dosage forms (tablets or capsules) are the predominant form to administer active pharmaceutical ingredients (APIs) to the…”
Get full text

Quantifying Pharmaceutical Film Coating with Optical Coherence Tomography and Terahertz Pulsed Imaging: An Evaluation by Lin, Hungyen, Dong, Yue, Shen, Yaochun, Zeitler, J Axel

“…Spectral domain optical coherence tomography (OCT) has recently attracted a lot of interest in the pharmaceutical industry as a fast and non-destructive…”
Get more information

Towards simultaneous determination of tablet porosity and height by terahertz time-domain reflection spectroscopy by Anuschek, Moritz, Kvistgaard Vilhelmsen, Thomas, Axel Zeitler, J., Rantanen, Jukka

“…[Display omitted] The quality control of pharmaceutical tablets is still based on testing small sample numbers using at- and off-line testing methods…”
Get full text

THz-TDS transflection measurements as a process analyser for tablet mass by Anuschek, Moritz, Kvistgaard Vilhelmsen, Thomas, Axel Zeitler, J., Rantanen, Jukka

“…[Display omitted] Tablet content and content uniformity are essential for the market release of the drug product. For tablets, content and uniformity are…”
Get full text

The Disintegration Process in Microcrystalline Cellulose Based Tablets, Part 1: Influence of Temperature, Porosity and Superdisintegrants by Yassin, Samy, Goodwin, Daniel J, Anderson, Andrew, Sibik, Juraj, Wilson, D Ian, Gladden, Lynn F, Zeitler, J Axel

“…Disintegration performance was measured by analysing both water ingress and tablet swelling of pure microcrystalline cellulose (MCC) and in mixture with…”
Get more information

Chasing the “Killer” Phonon Mode for the Rational Design of Low‐Disorder, High‐Mobility Molecular Semiconductors by Schweicher, Guillaume, D'Avino, Gabriele, Ruggiero, Michael T., Harkin, David J., Broch, Katharina, Venkateshvaran, Deepak, Liu, Guoming, Richard, Audrey, Ruzié, Christian, Armstrong, Jeff, Kennedy, Alan R., Shankland, Kenneth, Takimiya, Kazuo, Geerts, Yves H., Zeitler, J. Axel, Fratini, Simone, Sirringhaus, Henning

“…Molecular vibrations play a critical role in the charge transport properties of weakly van der Waals bonded organic semiconductors. To understand which…”
Get full text

Investigating the effect of sintering rate and solvent type on the liquid transport kinetics of α-alumina powder compacts by Al-Sharabi, Mohammed, Markl, Daniel, Vivacqua, Vincenzino, Bawuah, Prince, MacLean, Natalie, York, Andrew P.E., Axel Zeitler, J.

“…The ceramic materials' properties and the penetrating liquid both influence liquid transport into ceramic catalytic materials. Terahertz pulsed imaging (TPI)…”
Get full text

Advances in terahertz time-domain spectroscopy of pharmaceutical solids: A review by Bawuah, Prince, Zeitler, J. Axel

“…The rapid development of terahertz time-domain spectroscopy (THz-TDS) as a highly versatile analytical tool for the characterisation of pharmaceutical…”
Get full text

Glassy dynamics of sorbitol solutions at terahertz frequencies by Sibik, Juraj, Shalaev, Evgenyi Y, Zeitler, J Axel

“…The absorption spectra of D-sorbitol and a range of its concentrated aqueous solutions were studied by terahertz spectroscopy over the temperature interval of…”
Get more information

Review of Terahertz Pulsed Imaging for Pharmaceutical Film Coating Analysis by Alves-Lima, Décio, Song, Jun, Li, Xiaoran, Portieri, Alessia, Shen, Yaochun, Zeitler, J Axel, Lin, Hungyen

“…Terahertz pulsed imaging (TPI) was introduced approximately fifteen years ago and has attracted a lot of interest in the pharmaceutical industry as a fast,…”
Get full text

THz-TDS as a PAT tool for monitoring blend homogeneity in pharmaceutical manufacturing of solid oral dosage forms: A proof-of-concept study by Anuschek, Moritz, Skelbæk-Pedersen, Anne Linnet, Skibsted, Erik, Kvistgaard Vilhelmsen, Thomas, Axel Zeitler, J., Rantanen, Jukka

“…[Display omitted] The process analytical technology (PAT) framework is well established and integral to facilitate process understanding, enable a transition…”
Get full text

Terahertz Time-Domain and Low-Frequency Raman Spectroscopy of Organic Materials by Parrott, Edward P.J., Zeitler, J. Axel

“…With the ongoing proliferation of terahertz time-domain instrumentation from semiconductor physics into applied spectroscopy over the past decade, measurements…”
Get full text

Diffusion and swelling measurements in pharmaceutical powder compacts using terahertz pulsed imaging by Yassin, Samy, Su, Ke, Lin, Hungyen, Gladden, Lynn F, Zeitler, J Axel

“…Tablet dissolution is strongly affected by swelling and solvent penetration into its matrix. A terahertz-pulsed imaging (TPI) technique, in reflection mode, is…”
Get more information

Non-destructive Determination of Disintegration Time and Dissolution in Immediate Release Tablets by Terahertz Transmission Measurements by Markl, Daniel, Sauerwein, Johanna, Goodwin, Daniel J., van den Ban, Sander, Zeitler, J. Axel

“…ABSTRACT Purpose The aim of this study was to establish the suitability of terahertz (THz) transmission measurements to accurately measure and predict the…”
Get full text

Uncovering the Connection Between Low-Frequency Dynamics and Phase Transformation Phenomena in Molecular Solids by Ruggiero, Michael T, Zhang, Wei, Bond, Andrew D, Mittleman, Daniel M, Zeitler, J Axel

“…The low-frequency motions of molecules in the condensed phase have been shown to be vital to a large number of physical properties and processes. However, in…”
Get full text

Tuning the Acid/Base Properties of Nanocarbons by Functionalization via Amination by Arrigo, Rosa, Hävecker, Michael, Wrabetz, Sabine, Blume, Raoul, Lerch, Martin, McGregor, James, Parrott, Edward P. J, Zeitler, J. Axel, Gladden, Lynn F, Knop-Gericke, Axel, Schlögl, Robert, Su, Dang Sheng

“…The surface chemical properties and the electronic properties of vapor grown carbon nanofibers (VGCNFs) have been modified by treatment of the oxidized CNFs…”
Get full text

Mesoscopic Structuring and Dynamics of Alcohol/Water Solutions Probed by Terahertz Time-Domain Spectroscopy and Pulsed Field Gradient Nuclear Magnetic Resonance by Li, Ruoyu, D’Agostino, Carmine, McGregor, James, Mantle, Michael D, Zeitler, J. Axel, Gladden, Lynn F

“…Terahertz and PFG-NMR techniques are used to explore transitions in the structuring of binary alcohol/water mixtures. Three critical alcohol mole fractions (x…”
Get full text

Simultaneous investigation of the liquid transport and swelling performance during tablet disintegration by Al-Sharabi, Mohammed, Markl, Daniel, Mudley, Theona, Bawuah, Prince, Karttunen, Anssi-Pekka, Ridgway, Cathy, Gane, Patrick, Ketolainen, Jarkko, Peiponen, Kai-Erik, Rades, Thomas, Zeitler, J. Axel

“…[Display omitted] Fast disintegrating tablets have commonly been used for fast oral drug delivery to patients with swallowing difficulties. The different…”
Get full text

Terahertz-Based Porosity Measurement of Pharmaceutical Tablets: a Tutorial by Bawuah, Prince, Markl, Daniel, Farrell, Daniel, Evans, Mike, Portieri, Alessia, Anderson, Andrew, Goodwin, Daniel, Lucas, Ralph, Zeitler, J. Axel

“…Porosity, one of the important quality attributes of pharmaceutical tablets, directly affects the mechanical properties, the mass transport and hence tablet…”
Get full text

Analysis of the Hydration Water around Bovine Serum Albumin Using Terahertz Coherent Synchrotron Radiation by Bye, Jordan W, Meliga, Stefano, Ferachou, Denis, Cinque, Gianfelice, Zeitler, J. Axel, Falconer, Robert J

“…Terahertz spectroscopy was used to study the absorption of bovine serum albumin (BSA) in water. The Diamond Light Source operating in a low alpha mode…”
Get full text